Over-the-counter treatments can be tried, but are rarely effective. A doctor may suggest any of the following treatments.

Oral antifungal (for example, itraconazole, fluconazole, and terbinafine). The drug should be taken for 4 to 12 weeks. This drug has an indication in the event of matrix attack of onychomycosis (attack of the nail located under the skin) and it is associated with a local treatment which will be continued, in turn until complete recovery: the final result is only visible when the nail has grown back completely. Recovery occurs once in two and once in four in people with diabetes and the elderly1. These drugs can cause unwanted effects (diarrhea, nausea, skin irritation, itching, drug-induced hepatitis, etc.) or a strong allergic reaction, in which case a doctor should be consulted. Follow preventive measures throughout treatment and after treatment is completed.

Medicated nail polish (for example, ciclopirox). This product is obtained prescription. It must be applied every day, for several months. However, the success rate is low: less than 10% of people who use it manage to treat their infection.

Topical medications. There are other medicines in the form of cream or lotion, which can be taken in addition to treatment with oral.

Removal of the infected nail. If the infection is severe or painful, the nail is removed by the doctor. A new nail will grow back. It may take year before it grows back completely.