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Loratadine is a second-generation long-acting antihistamine, a selective antagonist of peripheral H1 receptors.
Loratadine – properties
Loratadyna has a weak bronchodilator effect, blocks histamine-induced bronchospasm in patients with asthma, reduces stress bronchospasm. It poorly penetrates into the CNS. It is metabolized in the liver with the participation of the cytochrome P-450 enzymes – CYP3A4 and CYP2D6. Its effect lasts for 24 hours, and it starts about 30 minutes after administration, and the maximum strength is reached from 4 to 6 hours after it. You can take it on an empty stomach, but if consumed with a meal, it is better absorbed, and the concentration of the active metabolite may increase by approx. 15%.
Loratadine – application
Loratadyna it is used to combat the symptoms of allergic (seasonal and perennial) rhinitis and chronic idiopathic urticaria.
Loratadine – contraindications
Loratadyna cannot be taken by people who are allergic or hypersensitive to any of the ingredients of the preparation. The full list of ingredients is included in the package leaflet. Loratadine should not be administered during pregnancy and breastfeeding. It is not recommended for children under two years of age.
Loratadine – precautions
Loratadyna should be used with caution in people with impaired kidney and liver function.
If skin allergy testing is performed, discontinue administration Loratadine 48 hours before they are carried out.
Loratadine – dosage
Loratadyna in adults, it is usually administered in the amount of 1×10 mg per day. In the case of children up to 12 years of age and weighing less than 30 kg, it will be 5 mg per day, with a greater weight – 10 mg.
Loratadyna administered to people with severe hepatic insufficiency is 10 mg twice a day, and if the patient’s weight is less than 2 kg, it will be 30 mg twice a day.
Loratadine – side effects
Loratadyna may have some side effects, but they are very rare. They manifest with drowsiness, fatigue, headaches, nervousness, increased appetite and insomnia. There is a small chance of anaphylactic reactions, tachycardia, liver dysfunction, palpitations, dry mouth, as well as nausea and vomiting.
Overdosing of the drug may lead to tachycardia, headache and drowsiness. In these cases, gastric lavage and administration of activated charcoal are necessary.
Loratadine – interactions
Loratadyna when used simultaneously with cytochrome P-450 inhibitors, it increases the plasma concentration of loratadine and its active metabolite.
Loratadine – price
The drug is sold in the form of tablets. There are 10 to 90 pieces in the package. The price of the drug depends on the number of tablets and the degree of reimbursement. The cost of the largest package (90 pcs) without a refund should be less than PLN 50. Loratadine is available in several versions – Loratadine Pylox, Loratadine Galena. The physician should prescribe the appropriate one for the patient.