Diclac – characteristics, forms, indications, action, composition

Proven content

Diclac is a pain reliever, antipyretic and anti-inflammatory medicine that you can get in a variety of forms. The drug can be used to relieve the symptoms of rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. Diclac can even be used by women during a painful period. Find out more about Diclac.

Diclac – characteristics

Diclac is a pain reliever, anti-inflammatory and antipyretic medicine that you can get from the pharmacy in various forms. Most often, in order to buy it, you must have a prescription issued by a doctor. Diclac can be purchased in the form of:

1. solution as injection 75 mg / 3 ml;
2. rectal suppositories 50 mg;
3. rectal suppositories 100 mg;
4. gastro-resistant tablets 50 mg;
5. tabletek Diclac Duo 75 mg;
6. tabletek Diclac Duo 150 mg;
7. Diclac LipoGel 10 mg / g topical gel, which you can get without a prescription.

Diclac injection solutions are partially reimbursed. It is a drug classified as a non-steroidal anti-inflammatory drug. Regardless of the character, The active substance in Diclacu is diclofenac sodium, i.e. a derivative of aminophenylacetic acid, which has anti-inflammatory, antipyretic and analgesic properties.

Therefore, Diclac has a soothing effect on swelling, inflammation and lowering the temperature, and when given in the form of injections, it additionally inhibits the aggregation of platelets.

Diclac in the form of modified release tablets has a similar mechanism to the Diclac 50 gastro-resistant tablets. They differ in the subsequent transformations they undergo. They have two layers. The first pink contains the initial dose of the drug, which is quickly absorbed into the body. On the other hand, the second, white layer of the drug is absorbed more slowly, gradually releasing the active substance.

Diclac gel is intended for external use at the site of injury or pain. In this case, the active substance penetrates the skin, and the gel additionally cools and soothes the ailments.

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Diclac – indications

The indication for the use of Diclac is:

1. treatment of people with rheumatic arthritis in the form of inflammation or degeneration. This applies especially to rheumatoid arthritis, juvenile rheumatoid arthritis, ankylosing spondylitis, pain syndromes associated with degeneration of the spine and extra-articular rheumatism;
2. acute gout and other types of pain, such as complications from dental or orthopedic procedures with swelling or inflammation;
3. supporting the treatment of inflammation of the reproductive organs and helping women during painful periods;
4. migraine;
5. supporting basic treatment in the treatment of infections and inflammations of the ears, nose and throat when severe pain occurs.

In addition, Diclacu solution for injection will help patients with renal and hepatic colic.

Another application is Diclac gel, which should be applied topically to people who complain of pain as a result of injuries or inflammation. Pain occurs in tendons, ligaments, muscles and joints. Diclac gel should be used in the case of:

1. sprains;
2. contusions;
3. muscle strain;
4. back pain;
5. inflammation of soft tissues such as tennis elbow.

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Diclac – contraindications

Contraindication to the use of Diclac is:

1. hypersensitivity, that is, allergy to the active substance or any component of the drug;
2. hypersensitivity to acetylsalicylic acid or other NSAIDs – this applies to symptoms such as bronchial asthma, allergic skin reactions, edema;
3. the patient’s history of ulcer disease of the stomach or duodenum with bleeding or perforation of the digestive system;
4. gastrointestinal bleeding or perforation after taking NSAIDs;
5. reported renal or hepatic failure;
6. congestive heart failure;
7. ischemic heart disease;
8. peripheral vascular disease;
9. cerebrovascular disease;
10. inflammation of the anus and rectum;
11. third trimester of pregnancy.

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Diclac – composition

The composition of Diclacu varies depending on the form:

1. Diclac solution for injection 75 mg / 3 ml contains – a 3 ml ampoule of Diclac contains 75 mg of diclofenac sodium and the following excipients: N-acetylcysteine, benzyl alcohol, mannitol, sodium hydroxide, propylene glycol and water for injections;
2. Diclac rectal suppositories 50 or 100 mg – in 1 Diclac suppository there is 50 or 100 mg of diclofenac sodium, and the excipient is solid fat;
3. Diclac tablets 50 mg – 1 tablet of Diclac contains 50 mg of diclofenac sodium, and the excipients are lactose monohydrate, corn starch, calcium hydrogen phosphate dihydrate, microcrystalline cellulose, sodium carboxymethyl starch, magnesium stearate, colloidal silica, eudragit L 30D, titrate, talc, triethyl dioxide (triethyl dioxide) E 171), yellow iron oxide (E 172);
4. Diclac Duo 75 mg and 150 mg modified-release tablets – 1 tablet of Diclac Duo contains 75 or 150 mg of diclofenac sodium, and the excipients are in the unmodified-release layer: lactose monohydrate, calcium hydrogen phosphate dihydrate, microcrystalline cellulose, magnesium stearate, sodium carboxymethyl starch ( type A), anhydrous colloidal silica, maize starch, red iron oxide (E172), and in the extended-release layer: lactose monohydrate, hypromellose, purified water, magnesium stearate;
5. Diclac gel LipoGel 10 mg / g – 1 g of Diclac LipoGel contains 10 mg of diclofenac sodium, and the excipients are: RRR-α-tocopherol, carbomer 980 NF, decyl oleate, 2-octyldodecanol, lecithin, ammonium hydroxide 10%, disodium edetate, fragrance oil “Vert de Creme ”, isopropyl alcohol, purified water.

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Diclac – dosage

The dosage of Diclac is usually determined by your doctor. It all depends on the form of prescribed Diclac:

1. Diclac 50 tablets – they can only be used by adults and adolescents over 14 years of age. Diclacu doses for adults range from 100 to 150 mg initially. The daily dose of Diclacu should be divided into 2-3 tablets taken during the day. The drug is used before a meal and should be washed down with a small amount of water. In the case of mild symptoms or the need to use Diclacu for a long time, the usual dose is 100 mg. If the patient is struggling with morning stiffness or night pains, the doctor may replace the tablets with suppositories. In the case of painful menstruation, the doctor determines the dose individually;
2. Diclac Duo tablets – they have a modified action, therefore they are intended for adults only. The dose indicated by the manufacturer is 75-150 mg per day. Treatment always starts with the lowest possible dose, 75 mg. If this does not work, the dose is increased, but the daily dose of 150 mg may not be exceeded. Diclac in this form is taken with a meal and washed down with water. If the patient complains of night discomfort, the drug is administered in the evening;
3. Diclac rectal suppositories – suppositories are used rectally. They are administered in doses ranging from 100 to 150 mg per day. The total daily dose is divided into 2 or 3 doses. They can be used to supplement treatment with Diclac tablets;
4. Diclac solution for injection – the drug is administered intramuscularly in this form. The recommended dose is 75 mg, i.e. one ampoule a day. The injections are made in the upper outer square of the buttock. Injections can be given for a maximum of 2 days, and if symptoms persist, treatment can be continued with tablets or suppositories;
5. Diclac LipoGel – the drug is intended for external use, on clean and intact skin. It can be used by adults and adolescents over 14 years of age. Apply the gel to the skin 3-4 times a day on the sore spot. It should be gently rubbed in. When using Diclac gel, remember to wash your hands thoroughly after each application, unless you put it on your hands. Avoid the area around the eyes and mouth. Diclac gel is available over the counter and can be used without consulting your doctor. People who have strained soft tissues or suffer from rheumatism of soft tissues can use it for a maximum of 14 days. People over 18 years of age using the gel due to osteoarthritis can use it for up to 21 days. If symptoms worsen or do not improve after 7 days, please consult your doctor. A visit to the doctor is also necessary in the case of adolescents between 14 and 18 years of age, when it is necessary to use the gel for more than 7 days.

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Diclac – overdose

Diclac should be used as prescribed by the treating physician. Do not exceed the dose indicated by the doctor. An overdose of Diclac may be dangerous to the health and life of the patient. If you take more Diclac than recommended, consult your doctor or pharmacist. It is also worth going to the emergency department if you notice symptoms of an overdose of Diclac.

The symptoms of an overdose with Diclac are not very specific. However, it is worth paying attention to whether there are any:

1. vomiting;
2. diarrhea;
3. gastrointestinal haemorrhages;
4. dizziness;
5. Tinnitus;
6. seizures.

If overdose does occur, management will depend on the patient’s condition, type of symptoms and their intensity.

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Diclac – side effects

The side effects of Diclacu listed below apply to the rectal and oral formulations. Most often it appears:

1. headache and dizziness;
2. nausea, vomiting, diarrhea, abdominal pain, indigestion, gas, and disturbed appetite;
3. palpitations and chest pains, even a heart attack or heart failure.

Rare side effects of Diclacu include:

1. hypersensitivity reactions, including anaphylactic and anaphylactoid reactions (shock and hypotension);
2. increased drowsiness, shortness of breath, attacks of bronchial asthma;
3. inflammation of the gastric mucosa;
4. gastrointestinal bleeding;
5. vomiting and diarrhea with blood, tarry stools, inflammation of the rectum or the liver;
6. liver disorders;
7. jaundice.

Very rare side effects of using Diclacu include:

1. blood count disorders (thrombocytopenia, hemolytic or aplastic anemia, leukopenia, agranulocytosis);
2. depression, nightmares, confusion;
3. psychotic disorders;
4. problems with memory,
5. seizures and paresthesias;
6. meningitis;
7. stroke;
8. changes in taste, vision and hearing;
9. arterial hypertension, vasculitis;
10. pneumonia;
11. inflammation of the tongue or oral mucosa;
12. renal failure or interstitial nephritis;
13. dermatological problems, e.g. toxic epidermal necrolysis, eczema or hair loss.

Side effects may also appear as a result of using Diclac LipoGel. Most often, these are contact symptoms of hypersensitivity, i.e. erythema, rash, itching. Bullous epidermal detachment has been observed in some people.

Diclac – interaction with alcohol

Manufacturer of the drug Diclac did not include information on the interaction of the drug with alcohol in the package leaflet.

Diclac – pregnancy and breastfeeding

Consult your doctor about taking any medications during pregnancy and breastfeeding to explain the risks and benefits of using it.

Studies on the safety of Diclac have shown that when taken in early pregnancy, it may increase the risk of miscarriage and cardiac disorders of the fetus. Therefore, it is best not to take Diclacu in the first and second trimesters of pregnancy, unless absolutely necessary. In such cases, extreme caution should be exercised and the lowest possible dose of Diclac should be used.

Diclac is also not indicated in the third trimester, because then it may have a toxic effect on the development of the child’s cardiovascular system and may impair the functioning of the kidneys and lead to their failure. A negative effect on the fetal lungs has also been observed as it can induce premature closure of the ductus arteriosus and pulmonary hypertension.

Diclac used in the last stage of pregnancy increases the risk of complications also during the delivery itself. Bleeding may occur and contractions of the uterus may be inhibited, resulting in delayed and prolonged delivery.

Breastfeeding women must remember that the drug passes into breast milk in minimal amounts and may lead to side effects in the baby. This also applies to Diclac gel, although there is no data to confirm that the drug passes into breast milk in this way.

However, if absolutely necessary, the gel may be used in nursing women. However, treatment should be as short as possible and the medicine should not be applied to the breast area in order to minimize the risk of accidental ingestion of the medicine by the baby while feeding.