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Diaprel (a glycoside) is an oral diabetes medicine. It is in the form of modified release tablets. Diaprel reduces blood glucose levels and causes the release of insulin. The active substance in Diaprel is gliclazide.
How does Diaprel work?
diaprel stimulates the release of insulin into the blood and reduces glucose levels. It is used to treat type 2 diabetes (non-insulin dependent diabetes). Gliclazide present in Diaprelu binds to the membrane protein of beta cells in the pancreas, which allows the potassium channel to be closed, calcium channels to open and calcium ions to flow into the cell. This, in turn, signals the production and release of insulin. Gliclazide is well absorbed from the gastrointestinal tract, its effect lasts from 6 to 12 hours. It is then excreted in the urine.
Indications for the use of Diaprel
diaprel is used in treatment non-insulin dependent diabetes mellitus (type 2 diabetes) when adequate diet, weight loss and exercise therapy is not sufficient to maintain normal blood glucose levels.
Contraindications to the use of Diaprel
diaprel it shouldn’t be applied if you are allergic or hypersensitive to sulfonamides or sulfonylurea derivatives, as well as if the patient is allergic to any other ingredient of the preparation. You shouldn’t use Diaprelu to treat type 1 (insulin-dependent) diabetes, in diabetic pre-coma or coma, in diabetic ketoacidosis, in severe renal or hepatic impairment and when miconazole is used.
Contraindication to the use of Diaprel is pregnancy and breast-feeding.
Keep extreme cautionby applying diaprel when the patient does not eat meals regularly (this may result in hypoglycaemia, i.e. a significant reduction in blood sugar levels). Consumption of carbohydrates (sugars) during drug therapy diaprel it must be adequate to the activity and physical effort undertaken by the patient – the sugar level must not be allowed to fall below the norm. A contraindication for use Diaprelu there is also excessive consumption alcohol and the parallel use of other drugs.
Side effects when taking Diaprel
diaprel like almost any drug it can induce a series side effects and side effects. These include, in particular, symptoms of hypoglycaemia (hypoglycaemia) such as headache, hunger pangs, nausea, vomiting, fatigue and weariness, sleepiness, sleep disturbances, restlessness, concentration disorders, aggression, depression, confusion, increased reaction time, decreased alertness, sensory disturbance, dizziness, muscle tremors, delirium, seizures, loss of consciousness, breathing problems, decreased heart rate, sweating, palpitations, anxiety, increased heart rate, high blood pressure, moist skin, limb paresis. Severe hypoglycaemia may resemble the symptoms of a stroke. You should then give the patient sugar (carbohydrates) and consult a doctor. Be aware that diet and exercise have an effect on blood glucose levels, so dose Diaprelu it must be selected individually and may be subject to change.