“Will there be a wave of COVID-19 related memory impairment and dementia in the future?”

The coronavirus affects not only the lungs. SARS-CoV-2 affects many organs, including the brain. Research shows that many people who have been beaten by COVID-19 suffer from neurological problems, including problems with memory and concentration. “Will there be a wave of memory deficits, cognitive impairment and dementia related to COVID-19 in the future?” – wonders the neurobiologist, prof. Natalie C. Tronson from the University of Michigan.

1. Many COVID-19 patients experience neurological symptoms. Healers also complain of memory problems and frequent problems with concentration
2. Neurobiologist prof. Natalie C. Tronson: As I review emerging scientific literature, my question is: will there be a wave of memory deficits, cognitive impairment and dementia related to COVID-19 in the future? » – the scientist wonders
3. It will be many years before we know if SARS-CoV-2 coronavirus infection is associated with a higher risk of cognitive decline or Alzheimer’s disease. But this potential risk can be reduced or mitigated, says Tronson

Neurological symptoms in COVID-19 patients

“Of all the frightening ways SARS-CoV-2 coronavirus affects the body, one of the more insidious is its effects on the brain,” Prof. Tronson.

Many COVID-19 patients experience neurological symptoms, including loss of smell and taste, headache or dizziness, altered consciousness. Long-term effects are also reported, including chronic fatigue syndrome and Guillain-Barré syndrome (the disease leads to progressive weakness in the muscles due to damage to the peripheral nerves). Healers also complain of memory problems and frequent problems with concentration. Scientists suspect that these people at a later age may be more likely to develop dementia.

1. What does it mean when someone has recovered from the coronavirus?

As Natalie C. Tronson explains, these effects may be caused by direct infection of the brain tissue by SARS-CoV-2. Growing evidence, however, suggests that an immune system response can lead to inflammation, which also damages the brain and nerves.

“As I review emerging scientific literature, my question is: will there be a wave of memory deficits, cognitive impairment and dementia associated with COVID-19 in the future?” – the scientist wonders.

1. The coronavirus affects not only the lungs. It affects all organs

What Happens in the Brain During Illness?

Many of the symptoms we attribute to infection are actually caused by a protective response from the immune system. Like the example of prof. Tronson gives a runny nose during a cold. “It’s not a direct result of the virus, but the immune system’s response to a cold,” he explains. Likewise, general illness accompanying malaise, fatigue, and social withdrawal – these symptoms are caused by the activation of specialized immune cells in the brain called neuroimmune cells. – These changes, while burdensome, are highly adaptive and extremely beneficial. By resting, you keep the energy necessary for the immune system to function, he explains.

The immune system in the brain also plays a number of other roles, the scientist emphasizes. It is known, for example, that neuroimmune cells, which are briefly located at the connections between brain cells, are essential for the proper functioning of memory.

During disease, including COVID-19, specialized immune cells in the brain are activated, firing large amounts of ‘inflammatory signals’ and modifying the way they communicate with neurons. Unfortunately, this also means, among others the fact that neural connections that are important for memory preservation are damaged. According to the scientist, the effect may even be permanently impaired memory. This can occur through permanent damage to the connections between neurons or the neurons themselves, and through more subtle changes in the way nerve cells function.

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1. Where do memory problems come from?

How COVID-19 might affect memory?

Prof. Natalie C. Tronson emphasizes that the potential link between COVID-19 and its lasting effects on memory is based on observations of the effects of other diseases. “Many patients who recover from a heart attack or bypass surgery report persistent cognitive deficits that worsen with aging,” says the neuroscientist. Similar observations apply to sepsis. Even mild inflammation, including chronic stress, is now recognized as risk factors for dementia and cognitive decline during aging, the scientist emphasizes.

1. Healers still have health problems after defeating COVID-19. What’s happening?

It will be many years before we know if SARS-CoV-2 coronavirus infection is associated with a higher risk of cognitive decline or Alzheimer’s disease. But this potential risk can be reduced or mitigated by preventing COVID-19 and by striving to reduce the duration and severity of the disease. Several of the most recent treatments for COVID-19 are drugs that inhibit excessive immune activation and inflammation. Potentially, these therapies can also reduce the effects of the inflammatory response on the brain.

– COVID-19 will continue to impact health and well-being long after the pandemic ends. Therefore, it will be crucial to further evaluate the effects of COVID-19 in terms of susceptibility to subsequent cognitive decline and dementia, concludes Prof. Natalie C. Tronson from the University of Michigan.

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