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Why is only urobilinogen elevated in the research results? What is this indicator and what role does it play in our body? Is it worth repeating the test? The question is answered by the drug. Anna Mitschke.
Why is urobilinogen level rising?
Hello. I’m 45 years old. I do urine tests and morphology regularly. A few days ago, I did just that blood test with a smear and I urinated for analysis. Today I got the results and I have a question related to the results of the urinalysis. I am aware that all the results should be analyzed globally, not each separately, but looking at the norms, none is exceeded, except urobilinogen.
According to the standards, on the score sheet I have elevated urobilinogen the rest of the results are normal. What does the increased urobilinogen testify to? What exactly is urobilinogen and what role does it play in the body? I am not sick, I do not have any chronic diseases, I have no pain, why do I have elevated urobilinogen?
I wonder if the inflated results may be due to an incorrect diet, should I go to my family doctor who will give me a referral for tests, or maybe I should go to another specialist? So far my blood count and urine results have been normal, so I’m worried where this elevated norm is from. Please reply.
The doctor explains what the increased urobilinogen proves
Urobilinogen is a bile pigment made from bilirubin. Bilirubin is the end product of heme metabolism. Haem, on the other hand, comes mainly from the hemoglobin contained in the blood. The breakdown of hemoglobin occurs in the cells of the spleen, liver and marrow. As a result, the resulting bilirubin is transported to the liver, where its further transformation processes take place. The resulting metabolites are excreted in the bile into the intestines. In the intestines, urobilinogens are produced with the participation of bacteria.
Some of it is absorbed into the blood and goes to the liver, and the rest is excreted in the urine. In the case of liver damage, it cannot capture a sufficient amount of urobilinogens and therefore they are excreted in the urine in an increased amount. Determination of bilirubin and urobilinogen in urine is of diagnostic importance in the case of diseases of the liver and biliary tract. Urobilinogen is determined with strip tests, its normal concentration in urine should not exceed 1 mg / dl.
Increased levels of urobilinogen in urine it is stated, inter alia, in case of hemolytic jaundice, liver cirrhosis, damage to hepatocytes (liver cells) against an inflammatory background. Acute hepatitis can be caused by primary hepatotropic viruses (which primarily target the liver) and secondary hepatotropic viruses (which cause systemic infection). An elevated result may be caused by the use of certain drugs, e.g. para-aminosalicylic acid, chlorpromazine, phenothiazine, sulfonamides.
However, the use of high concentrations of nitrite may result in a false negative. The diagnosis of liver disease or biliary tract disease requires more information. The diagnosis cannot be based solely on an incorrect result of one parameter. It is best to consult the result of the laboratory test with the doctor who ordered it. The doctor, after reviewing the patient’s medical history, will decide on the implementation of possible further diagnostics based on the medical history and physical examination.
— Lek. Anna Mitchke
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