What are the signs of a deadly form of COVID-19

Thanks to joint research of two universities (Italian in Sassari and Flinders in Australia), the main cause of death in patients after the inflammatory process with SARS-CoV-2 was found.

To obtain data, 19 studies were conducted, in which more than 5600 people from all over the world were involved. All results are carefully analyzed to identify the causes that contribute to the development of the disease and its transition to a dangerous form.

It turned out that the cause of the development of the deadly form of COVID-19 is the concentration of serum protein amyloid A (SAA) in the human body. People who died with the disease, or who had a hard time with COVID-19, had very high SAA levels. Moreover, in some patients, during the first two days, an increase in protein levels tenfold from the norm was noticed, and later they had a severe course of the disease.

The production of a large amount of protein is a consequence of the appearance in the body of several factors, namely tumor necrosis, interleukin-1β and -6 and interferon-gamma. While SAA stimulates the development of inflammation, in conjunction with these factors, it is able to provoke the production of cytokines, which in turn cause other complications, as well as a cytokine storm (a potentially lethal reaction of the immune system that causes tissue destruction in the focus of inflammation, simultaneously extends to adjacent tissues, and as it develops, it becomes systemic, covering the entire body).

Significant tissue and organ damage was observed in patients with high amyloid values. The most commonly affected are the kidneys, liver, lungs and heart.

The same studies helped explain the high likelihood of developing the disease in men, and create tests to identify people who require vaccination against SARS-CoV-2 in the first place in conditions of vaccine shortage.

Sources of
  1. Ijidonline.com. – Serum amyloid A concentrations, COVID-19 severity and mortality: An updated systematic review and meta-analysis.
  2. Springer.com. – Prognostic value of serum amyloid A in patients with COVID-19.

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