A drug that lowers blood pressure. A combined preparation containing an angiotensin converting enzyme inhibitor (ramipril) in combination with a substance with a moderate diuretic effect (hydrochlorothiazide).
Tritace 2,5 comb, -5 comb, Producent: Sanofi-Aventis
| form, dose, packaging | availability category | the active substance |
| tablets, 2,5 mg + 12,5 mg, 28 pcs | prescription drug | ramipryl, hydrochlorotiazyd |
| S1,2tabletki, 5 mg + 25 mg, 28 sztukr |
Tritace – indications
Treatment of hypertension in patients in whom ramipril or a thiazide diuretic (hydrochlorothiazide) monotherapy has not been effective.
Tritace – contraindications
Hypersensitivity to any component of the preparation, ACE inhibitors, thiazide sulfonamides or diuretics, history of angioedema (hereditary, idiopathic, due to the use of ACE inhibitors or angiotensin II receptor antagonists), extracorporeal methods of treatment causing contact of blood with negatively charged surfaces, severe failure kidney with creatinine clearance <30 ml / min in non-dialysed patients, haemodynamically significant bilateral renal artery stenosis or stenosis to a solitary kidney, significant electrolyte disturbances, severe hepatic insufficiency, hepatic encephalopathy, XNUMXnd and XNUMXrd trimester of pregnancy, breast-feeding.
Tritace – dosage
Adults:
The doctor will decide on the dosage individually. Usually 1 tablet once a day.
Treatment should be started with the lowest dose and then increased gradually, depending on the blood pressure. The maximum daily dose is 10 mg of ramipril and 25 mg of hydrochlorothiazide.
If a diuretic has been used, there is a risk of arterial hypotension after starting the preparation. If possible, your doctor will reduce the dose or stop using the diuretic before starting the combination.
Caution should be exercised in people with mild to moderate renal impairment. Your doctor will adjust the dosage. The maximum daily dose in this group of patients is 5 mg of ramipril and 25 mg of hydrochlorothiazide. If the creatinine clearance is less than 30 ml / min, the use of the preparation is contraindicated.
Caution should be exercised in patients with mild to moderate hepatic impairment and treatment should only be initiated under strict medical supervision. Your doctor will adjust the dosage. The maximum daily dose in this group of patients is 2,5 mg of ramipril and 12,5 mg of hydrochlorothiazide. If there are severe liver dysfunction, the preparation is contraindicated.
If you are elderly, your doctor will recommend a lower starting dose (increased risk of side effects).
It should not be used in children and adolescents up to 18 years of age due to the lack of data on the safety and efficacy of the preparation in this age group.