Tribux forte – composition, action, dosage, side effects

Proven content

Tribux forte is a drug used in gastroenterology and family medicine. It is used to regulate motor activity in disorders of the gastrointestinal tract. The active substance of the preparation is trimebutin, an organic chemical compound used as an oral diastolic drug that stimulates intestinal motility. This preparation is available only on prescription and its use requires consultation with a doctor or pharmacist. How does Tribux forte work? What are the indications and contraindications for its use? How to take it and dose it? What side effects can it cause? What drugs should not be combined with Tribux forte?

Tribux forte – general characteristics of the drug

Tribux forte is a drug that regulates gastrointestinal motility. The international name of this product is Trimebutini maleas. The preparation is available on prescription and is sold only in stationary pharmacies. The active substance of the drug is trimebutin maleate, which acts on the smooth muscles of the digestive tract, regulating its work.

Tribux forte are white tablets, oblong and biconvex in shape with a score line that allows division into two equal parts. The drug is sold in a paper package containing PVC / PVDC-Aluminum or PVC / PE / PVDC-Aluminum foil blisters, containing:

1. 10 tablets (1 blister of 10 tablets);
2. 20 tablets (2 blisters of 10 tablets);
3. 30 tablets (3 blisters of 10 tablets);
4. 60 tablets (6 blisters of 10 tablets each).

Tribux forte should be stored in its original packaging in order to protect it from moisture, at a temperature below 30 degrees Celsius, out of the reach of children.

The distributor of the drug in Poland is Biofarm Sp. z o. o. which is a Poznań-based family pharmaceutical company. The company was founded in 1988 and for years has been cooperating with international and national research centers as well as national and international experts in various fields of science. The company’s portfolio includes over 180 neurological, cardiological and internal medicine drugs, which are available on the domestic market as well as abroad.

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Tribux forte – composition and mode of action

The active substance of Tribux forte is trimebutin maleate (1 tablet contains 200 mg of this substance). Trimebutin is a synthetic antagonist of peripheral µ, δ and κ opioid receptors.

The active substance works by acting directly on smooth muscles of the gastrointestinal tract and regulating motor dysfunction without affecting the central nervous system. This substance normalizes the motility of the gastrointestinal tract.

It works by binding to peripheral opioid receptors, namely enkephalin receptors in the gut wall. The action of Tribux forte depends on the functional state of the digestive system.

Trimebutin acts on two different types of opioid receptors and may stimulate or inhibit gastrointestinal motility.

Peak plasma levels of trimebutin occur approximately 30 minutes after oral administration, after which the compound is mainly excreted in the urine.

In addition to the active substance, Tribux forte consists of auxiliary substances, including: lactose monohydrate, microcrystalline cellulose, povidone, crospovidone and magnesium stearate.

How are bowel diseases diagnosed and treated? Read: Bowel diseases – how to recognize them and how to treat them?

Tribux forte – indications for use

Among the indications for the use of Tribux forte, digestive system ailments are indicated, including:

1. gastrointestinal motility disorders – symptoms of irritable bowel syndrome;
2. disorders of the digestive tract and bile ducts accompanied by symptoms such as diarrhea, abdominal pain, intestinal cramps, constipation.

Tribux forte is mainly used to prevent and relieve symptoms associated with problems with the digestive system.

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Tribux forte – contraindications to use

Despite its effectiveness in treating digestive system disorders, Tribux forte cannot be used by every patient. The risk of using Tribux forte is always assessed individually by a doctor. Often, despite the existence of indications for the use of this drug, it is not always possible to use it.

The contraindication to the use of Tribux forte is mainly allergy to trimebutin or any of the other ingredients of the drug.

Tribux forte should not be used in children under 12 years of age and in women in the first trimester of pregnancy.

Some diseases and other circumstances may constitute a contraindication to use or an indication for a change in the dosage of the drug.

Due to the fact that Tribux forte contains lactose, the contraindication to its use is a diagnosis of galactose intolerance, lactase deficiency or malabsorption of glucose-galactose.

This preparation should also not be used in the case of people suffering from phenylketonuria, which is a metabolic disease with a genetic basis. In some cases, certain medical check-ups are necessary before using Tribux forte.

What is lactose intolerance and how do you recognize it? Check: Lactose intolerance

Tribux forte – dosage and method of taking

Tribux forte, like any other medicine, should be used according to the doctor’s instructions or according to the instructions provided on the package leaflet.

The drug is taken orally before a meal and washed down with a large amount of water. The dosage of the drug depends on the age of the patient and the condition being treated.

Adults suffering from Irritable Bowel Syndrome should take half a Tribux forte tablet (100 mg) three times a day before meals. In some cases, your doctor may increase your dose to a maximum of 600 mg per day, using several smaller doses.

For adults with gastrointestinal and biliary disorders, the dosage regimen depends on the symptoms associated with these conditions.

Tribux forte dose in the case of diarrhea or constipation should be 200 mg (1 tablet) before eating, 1 or 2 times a day. However, if the diseases are accompanied by abdominal pain or intestinal cramps, the recommended dose is 100 mg (half a tablet) 3 times a day, taken before meals.

If the above symptoms are very bothersome, your doctor may increase the dose to 600 mg per day by dividing it into several smaller doses.

In the case of children over 12 years of age, Tribux forte can be used up to a maximum daily dose of 6 mg / kg of the child’s body weight. However, for children under 12 years of age, the use of this drug is not recommended.

It is very important not to exceed the recommended doses, as this does not increase the effectiveness of the drug in any way, and can seriously harm the health and even life of the patient. If you take a larger dose, contact your doctor immediately, but if you miss a dose, do not take a double dose for refilling, just take the next dose at the usual time.

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Tribux forte- side effects

Each medicinal product, including Tribux forte, can cause side effects that may not occur in every person using this medicine.

After authorization of the medicinal product, it is important to report any suspected adverse reactions so that the benefit / risk balance of the medicinal product can be monitored.

The general classification of the frequency of adverse body reactions (ADRs) is based on the following principles: very common (≥1 / 10), common (≥1 / 100 to <1/10), uncommon (≥1 / 1 to <000/1), rare ( ≥100 / 1 to <10 / 000), very rare (<1 / 1), not known (cannot be estimated from the available data).

Among the side effects that may occur while using Tribux forte, we can distinguish:

1. common (1 to 10 in 100 people): drowsiness, drowsiness, fatigue, dizziness, feeling hot or cold, headache, lethargy, dry mouth, dysgeusia, diarrhea, indigestion, upper abdominal pain, numbness in the mouth, nausea, vomiting, constipation, feeling thirsty;
2. uncommon (affects 1 to 10 users in 1): rash;
3. rare (affects 1 to 10 users in 10): uneven heartbeat, liver problems including increases in liver enzymes ALT and AST in the blood;
4. very rare (less than 1 in 10 people, including isolated reports): anxiety, hearing impairment, hepatitis, skin changes (itching, hives, redness, blisters, lumps, exudation, erythema), urinary retention, menstrual disorders, painful breast enlargement in women, breast enlargement in men, breast pain.

If you experience any of these symptoms, please contact your doctor or pharmacist immediately.

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Tribux forte – interactions with other drugs

Simultaneous use of Tribux forte with other drugs may affect the way the drug works and interact with some substances. Before using this medicine, tell your doctor about any prescription drugs, over-the-counter drugs, or herbal products you are taking. Tribux forte should not be used together with:

1. zotepine, as it may increase the anticholinergic effect of the drug;
2. d-tubocurarine, as it may prolong and intensify its action;
3. cisapride – may weaken its action;
4. procainamide – because in combination with trimebutine it may increase the effect of the vagus nerve on inhibiting conduction in the heart, which may lead to an excessive increase in heart rate;
5. drugs acting on calcium channels, such as captopril, midazolam, reserpine and calcium channel antagonists, because in combination with trimebutin, the influx of calcium ions into the cells is reduced and, as a consequence, contraction of smooth muscles in the intestine may be inhibited.

Before prescribing the drug, the physician should individually assess the risk of taking the drug and conduct a detailed interview with the patient regarding other drugs used by him.

What interactions take place between popular medicinal preparations? Check: Dangerous interactions

Tribux forte during pregnancy and lactation

Pregnancy and breastfeeding are the periods in a woman’s life when she should not take medications without consulting a doctor first. In order to dispel all doubts and learn about all the potential risks and benefits associated with the use of a given drug, a pregnant woman should discuss her symptoms with the gynecologist responsible for the pregnancy.

Tribux forte should not be used in the first trimester of pregnancy and in the second and third trimesters it is allowed only if the doctor deems it necessary and the benefits for the woman clearly outweigh the possible risk to the fetus.

During breastfeeding, Tribux forte can be used only if necessary, after consulting a doctor or pharmacist.

What is worth remembering when using drugs during pregnancy? Check: Pregnancy and medications

Tribux forte – drug substitutes

Products containing trimebutin in the same form as Tribux Forte can be used as a drug substitute. Only a doctor or pharmacist can decide to replace Tribux forte with another drug. Medicines, although they contain the same active substance, may differ in the content of the active substance and have other excipients than Tribux forte.

Among the substitutes of the same form (tablets) as Tribux forte, we can distinguish:

• Ircolon (tablets);

• Ircolon Forte (tablets);

• Ircolon Gastro (tablets);

• Tribux (tablets);

• Tribux Bio (tablets).

Medicines containing trimebutin but not in a form other than Tribux forte are:

• Debretin (coated tablets);

• Debridat (granules for oral suspension);

• Debridat (coated tablets);

• Tribux (granules for oral suspension);

When is it worth asking for a drug substitute? Check: Swap when you can

Tribux forte – availability and price

Tribux forte is a preparation that is prescribed by a doctor on prescription. Packages containing 30 or 60 tablets are most often available in pharmacies. This preparation is not reimbursed by the National Health Fund, and the price for a package containing 30 tablets is around PLN 27, while a package with 60 tablets costs over PLN 33.

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