Travocort – how to apply? Indications and contraindications

Proven content

Travocort is a cream medicine for the topical treatment of initial fungal skin infections and inflammation. The preparation is mainly used in dermatology and prescribed by prescription to fight bacteria and fungi and to neutralize pain, itching and unpleasant burning. The cream is a complex substance consisting of two active substances: isoconazole and diflucortolone valerate. What is the overall composition of the drug and how does Travocort cream work? What are the indications and contraindications for its use and what side effects can it cause? How does it affect the course of pregnancy and can it be used during lactation? What precautions should be taken while applying the Travocort cream?

Travocort – general characteristics of the drug

Travocort is a prescription-only medicine that is prescribed to a specific person. Therefore, the medicine must not be passed on to others, as it may harm another person, even though the symptoms of the disease are the same. The international name of the drug is Isoconazole nitras + Diflucortoloni valeras.

Travocort is a white and yellow opaque cream. The active substance of this preparation is isoconazole and diflucortolone valerate. These substances influence the anti-fungal and anti-inflammatory effects of the cream.

Travocort is sold in an aluminum tube with a HDPE screw cap with a capacity of 15 g, placed in a cardboard box.

The price of Travocort cream is non-refundable and amounts to approximately PLN 38.

Travocort should be stored out of the reach and sight of children at a temperature below 30 degrees Celsius.

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Travocort – composition and action of the cream

Travocort is a combined preparation consisting of two active substances. The first substance is a drug from the group of imidazole derivatives (isoconazole), and the second is a drug from the group of corticosteroids (diflucortolone).

The active substance isoconazole has an antifungal activity against many microorganisms such as yeasts, yeast-like fungi, dermatophytes, molds and pathogens responsible for the formation of erythematous dandruff. In addition, it has an antibacterial effect against gram-positive bacteria.

Moreover, isoconazole inhibits the synthesis of ergosterol, which is an essential component of the fungal cell membrane. Thanks to this active substance, the cell membrane is damaged and, consequently, causes the death of the fungal cells.

However, the second active ingredient of the cream, which is diflucortolone, works anti-inflammatory, anti-itching and soothing on irritated skin.

This preparation is intended for topical application to the skin. After its application, the substances are absorbed quite quickly, reaching the maximum concentration in the stratum corneum and dermis within an hour, and high concentration is maintained for at least 7 hours.

Active substances to a negligible extent, i.e. only 1%, are absorbed into the blood. 1 g of Travocort cream contains 10 mg of isoconazole nitrate and 1 mg of diflucortolone valerate.

In addition, the composition of the cream is supplemented with auxiliary substances such as: white petroleum jelly, liquid paraffin, cetostearyl alcohol, polysorbate 60, sorbitan sterate, edetate disodium and purified water.

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Travocort – indications for the use of the cream

Travocort is a cream indicated for initial, topical use treatment of fungal skin infectionswith inflammation or eczema on the skin.

This preparation is mainly used in skin infections with dermatophytes, yeasts, yeast-like fungi, molds and fungi causing erythematous dandruff.

Most often, Travocort cream is indicated in mycosis of the hands and interdigital spaces of the feet, inguinal mycosis and mycosis in the genital area.

Travocort, thanks to diflucortolone, reduces inflammation and allergic skin reactions, alleviating skin ailments such as itching, burning and pain.

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Travocort – contraindications to the use of the cream

Travocort, although there are indications for its use, may not always be used in every patient.

The main contraindication to the use of this cream is hypersensitivity, i.e. allergic to the active substance isoconazole nitrate and diflucortolone valerate or any of the excipients.

Contraindications to the use of Travocort cream also include certain diseases and circumstances that may require you to completely abandon the drug or change the dosage of the preparation.

The use of the cream may require specific check-ups and a thorough medical history.

Contraindication to the use of Travocort is:

1. the presence of a viral infection, e.g., smallpox, shingles, and tuberculous or syphilitic skin infection;
2. acne vulgaris or rosacea;
3. post-vaccination reaction;
4. inflammation around the mouth.

If the situation described above applies to a patient, discontinue the drug and contact a doctor who will individually assess the risk of using Travocort cream in a given patient.

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Travocort – the method of application and dosage of the cream

Travocort is a cream medicine that is intended for topical application to the affected area of ​​the skin. The preparation should be used according to the doctor’s or pharmacist’s instructions.

Travocort cream can be used by adults and children over 2 years of age.

The preparation should be applied in a thin layer to the affected skin surface 2 times a day. The cream should not be used for more than 2 weeks from the start of treatment.

When the symptoms of the skin infection have resolved, treatment should be discontinued and treatment may be continued with an antifungal medicine that does not contain a corticosteroid.

When using Travocort cream to treat mycosis between the toes, it is recommended to place a strip of gauze with the drug applied between the toes.

The use of too much cream or accidental ingestion of the drug does not cause acute poisoning. If a dose is missed, a double dose should not be taken to make up for the forgotten dose.

It is recommended to use the next dose at the right time and continue treatment as previously advised by your doctor or pharmacist.

If you have any doubts before or during the use of the cream, consult your doctor or pharmacist immediately.

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Travocort – possible side effects

Travocort can cause side effects that may not be experienced by every person using this medicine. After authorization of the medicinal product, it is important to report any suspected adverse reactions so that the benefit / risk balance of the medicinal product can be monitored.

The side effects are usually mild and transient, and the expected benefits of the drug are usually greater than the harm resulting from the side effects.

Side effects may appear while taking, but also up to several weeks after discontinuing the drug.

Among the side effects that may occur as a result of using Travocort cream are:

1. a burning sensation where the cream is applied;
2. skin irritation at the application site;
3. drying the surface of the skin to which the cream was applied;
4. erythema;
5. skin stretch marks;
6. itching;
7. bubble formation in the treated area.

In addition, Travocort cream, as with other corticosteroids, may cause the following side effects:

1. inflammation of the hair follicles at the application site of the cream;
2. skin atrophy;
3. excessive hair growth;
4. perioral dermatitis;
5. expansion of superficial blood vessels;
6. skin allergic reactions;
7. acne-like lesions;
8. skin discoloration.

Moreover, in newborns whose mothers have used Travocort for a long time during pregnancy or during breastfeeding, or over a large area of ​​Travocort, adrenal function may decrease.

The occurrence of side effects during the use of the preparation depends on the individual reaction of the patient, his sensitivity and resistance to the cream. It is important that any disturbing symptom should be consulted with a doctor or pharmacist, who will decide whether to continue the treatment or change the dosage of Travocort.

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Travocort during pregnancy and breastfeeding

During pregnancy or breastfeeding, a woman should not take any medication without first consulting a doctor or pharmacist. In these cases, before using any medication, consult your doctor, who should explain beyond any doubt the potential risks and benefits associated with the use of the drug.

Animal studies have shown that glucocorticosteroids are toxic to reproduction. Some studies have suggested an increased risk of cleft palate in newborns.

As Travocort contains a glucocorticoid, it should not be used during the first trimester of pregnancy. However, the doctor should decide on the possibility of applying it during the remainder of pregnancy, assessing the risk-benefit ratio.

During pregnancy, a woman should avoid using the cream on large surfaces and applying it for a long time to the skin or using it under a dressing, because there is a risk of immunosuppression in the newborn and decreased adrenal function.

There is no information whether the ingredients of Travocort cream pass into human milk, but during breastfeeding it is recommended to avoid using the cream, especially on the breast skin, under dressings or on large areas of the skin, and for a long time.

Clinical indications for treatment with Travocort cream during breastfeeding or during pregnancy say that it requires careful analysis and consideration of the benefit / risk ratio by the physician.

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Travocort – warnings and precautions

The use of Travocort cream requires special care. Its use must be discussed with a doctor who will individually assess the risk that the implementation of Travocort may entail in the treatment of the patient’s disease. The initiation of treatment with this preparation requires special care and the application of specific precautions:

1.  in the case of coexisting bacterial superinfection, the doctor should prescribe antibacterial treatment;
2. avoid using the cream on large surfaces, for a long time and under an airtight dressing as it may lead to systemic side effects;
3. contact with the eyes and mucous membranes should be avoided, and the patient suffering from glaucoma should inform the doctor about this fact;
4. using Travocort cream in the genital area may damage the latex of the condom or vaginal rings, reducing the effectiveness of contraception;
5. the cream should be used with caution and for a short time on the skin of the face and in children who are at greater risk of systemic side effects;
6. the effectiveness of treatment with Travocort depends largely on the maintenance of personal hygiene;
7.  the alcohol content of the drug may cause a local skin reaction.