Contents
In line with its mission, the Editorial Board of MedTvoiLokony makes every effort to provide reliable medical content supported by the latest scientific knowledge. The additional flag “Checked Content” indicates that the article has been reviewed by or written directly by a physician. This two-step verification: a medical journalist and a doctor allows us to provide the highest quality content in line with current medical knowledge.
Our commitment in this area has been appreciated, among others, by by the Association of Journalists for Health, which awarded the Editorial Board of MedTvoiLokony with the honorary title of the Great Educator.
Tranxene is a trade name for a prescription-only psychotropic drug. The active substance of the preparation is clorazepate. Tranxene is not reimbursed by the National Health Fund.
We can find it at the pharmacy in the following doses and forms:
- Tranxene 5 mg capsules, 30 pcs.,
- Tranxene 10 mg capsules, 30 pcs.,
- Tranxene powder and solvent for solution for injection, 20 mg / 2 ml, 5 vials + solvent.
The manufacturer of the drug Tranxene is Sanofi-Aventis France.
How does Tranxene work?
The active substance of the drug is clorazepate (clorazepan) in the form of clorazepate dipotassium salt. Clorazepate is an organic compound belonging to the group of benzodiazepine derivatives. It has a typical anxiolytic effect. Lowers muscle tension, it does action sedative, hypnotic, anticonvulsant, it relieves anxiety and induces retrograde amnesia. It acts as an agonist at the GABA-omega receptors in the complex, which are a type of nerve conduction inhibitory receptor. The active metabolite of the drug is formed in the stomach by the decarboxylation process. Also in the case of administration by injection the drug works when it is converted to its active metabolite, desmethyldiazepam.
How is Tranxene used?
Each time Fr. application for drug treatment Tranxene the doctor has to decide. Bow apply in the form of capsules to relieve short-term anxiety, symptoms of withdrawal syndrome in alcoholism, temporarily to support the treatment of symptoms of neurosis. In the form of an injection, the drug is used in the event of sudden states of strong agitation and aggression, attacks of severe anxiety, sudden symptoms of abstinence syndrome and as an aid in tonic contractions in tetanus.
Treatment drug Tranxene it should be short-term and should only be used temporarily. Longer treatment can lead to physical and mental dependence on the drug. Besides, as a result longer use tolerance may develop and the drug may no longer be effective. ABOUT dosage each time a doctor has to decide.
Contraindications to the use of Tranxene and precautions
Ruthless a contraindication to use the drug is hypersensitivity to any component of the preparation, severe respiratory failure (benzodiazepines may inhibit breathing), sleep apnea syndrome, Myasthenia gravis, severe liver failure. Drug should not be used in children under 9 years of age, pregnant and lactating women. It has an impact on psychomotor performance.
Tranxene like psychotropic drug acting directly on the nervous system can trigger a series side effects (including anterograde amnesia, dementia, impaired consciousness, headache, dizziness, somnolence, reduction of skeletal muscle tone). Moreover Tranxene should be used very carefully in patients with various diseases and using other drugs, as it can have numerous interactions and always tell your doctor about all your medical conditions and any medications you are taking. It may increase the risk of suicide in people with suicidal thoughts.