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The indications for the use of the loop diuretic drug Toramide are: primary arterial hypertension, edema of hepatic and renal origin, as well as edema associated with congestive heart failure and pulmonary edema.
The drug Toramide affects diuresis (urine output). Its strength of action depends on doses, wherein action this can be very severe. The active substance of the preparation is torasemid. It is a strong diuretic, causing an increase in the amount of urine excreted. After oral administration torasemid it is rapidly and almost completely absorbed, reaching the maximum plasma concentration after 1-2 hours.
Before treatment with the preparation is started Toramide, care should be taken to correct hypokalemia, hyponatraemia, hypovolemia and micturition disorders. During prolonged use, especially in patients with a tendency to hyperuricaemia and gout, regular monitoring of electrolyte balance, blood glucose, uric acid, creatinine and lipids should be performed. In addition, carbohydrate metabolism in latent or symptomatic diabetes should be monitored.
Toramide – contraindications
Toramide should not be used by people suffering from hypersensitivity to torasemid, sulfonylurea derivatives or other ingredients of the preparation. Contraindications the following are also available for use: renal failure with anuria, hepatic coma and pre-coma, low blood pressure.
Toramide is also advised against during pregnancy and breastfeeding and in people with cardiac arrhythmias, as well as in a situation where there is simultaneous use with aminoglycoside antibiotics or cephalosporins or kidney failure has occurred after the use of other drugs that cause kidney damage. In addition, due to the lactose content, the drug Toremide should not be used in patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption.
Toramide – side effects
In the case of drug treatment Toramide disturbances of the water and electrolyte balance may occur, especially with application low sodium diet. It may appear hypokalemiaespecially on a low-potassium diet or in case of vomiting, diarrhea, overuse of laxatives and liver failure. With significant diuresis, especially at the beginning of treatment, and also in elderly patients, symptoms of loss of electrolytes and fluids, such as headache, dizziness, low blood pressure, weakness, somnolence, confusion, loss of appetite, and cramps may occur.
Torasemid may cause an increase in the concentration of uric acid, glucose and lipids in the plasma. Symptoms of metabolic alkalosis can worsen. In addition, the following may occur: gastrointestinal disorders, increase in plasma urea and creatinine levels, increase in the activity of some liver enzymes (e.g. GGT), dry mouth. Patients with urinary outflow obstruction may retain the urine. Among side effects limb paresthesias, thromboembolic complications and circulatory disorders are also mentioned, rarely – pancreatitis, decreased number of erythrocytes, leukocytes and platelets, allergic reactions (itching, rash, photosensitivity), visual and hearing disorders (tinnitus, hearing loss ).
The information is for reference only. In case of symptoms, consult a doctor. Any drug used improperly can be life or health threatening.