The severity of symptoms varies greatly from one affected person to another, but most have:

• A stretchy, very thin and translucent skin. Slow and difficult healing, repeated bruises, early stretch marks even in children.
• Very flexible joints. 

The most common forms of the disease, either the classic form (SED type I and II), the hypermobile form (SED type III) or the vascular form (SED type IV) include different combinations of symptoms:

• A fatigue excessive.
• Muscle, joint or abdominal pain, chronic and diffuse throughout the body.
• Repeated dislocations and sprains.
• Respiratory failure, sometimes mistakenly identified as asthma.
• Fragility of blood vessels and organs, prone to tearing, especially in type IV.
• Bowel problems or constipation.
• Gastroesophageal reflux disease.
• Urinary problems.
• Cardiac disorders, in particular at the level of the valves.
• Myopia or vision problems.
• Spontaneous nosebleeds.
• Heavy and painful periods in some women.
• Very sensitive and very flexible vocal cords.