Rulid against bacterial infections. How do I dose Rulid oral suspension?

Rulid is an antibacterial drug for systemic use. Macrolide antibiotic used to treat bacterial infections. It is recommended for tonsillitis caused by streptococci, bronchitis or atypical pneumonia. Rulid is in the form of coated tablets and tablets for oral suspension.

Rulid, Producer: Sanofi-Aventis

Rulid indications for use

Rulid is a macrolide antibiotic used to treat bacterial infections. It is used to treat the following infections caused by microorganisms that are sensitive to roxithromycin:

1. tonsillitis (angina) caused by streptococci,
2. acute sinusitis when beta-lactam antibiotics cannot be used,
3. exacerbation of chronic bronchitis,
4. superinfections in the course of acute bronchitis,
5. community acquired pneumonia in patients without risk factors and who are not in a severe clinical condition and if there are no symptoms suggesting pneumococcal infection (in the case of suspected atypical pneumonia, use of the drug is indicated, regardless of the severity of symptoms),
6. skin and subcutaneous tissue infections with a mild course,
7. non-gonococcal infection of the genital organs caused by chlamydia or ureaplasmas (this indication applies only to the film-coated tablet formulation).

Rulid and contraindications

Contraindications to the use of Rulid are:

1. hypersensitivity to any component of the preparation or to other macrolide antibiotics.
2. During treatment with roxithromycin, any of the following preparations are contraindicated: astemizole, cisapride, pimozide, terfenadine, ergot alkaloids (ergotamine or dihydroergotamine).

Dosage

In adults, the preparation is in the form of 150 mg film-coated tablets, and in children, the preparation is in the form of 100 mg film-coated tablets or in the form of tablets for oral suspension, according to the doctor’s recommendations.

1. Adults: 150 mg twice a day (morning and evening), every 2 hours. Dosage adjustment is not necessary in the elderly.
2. Children: 5-8 mg / kg body weight daily in 2 divided doses every 12 hours.
3. For children weighing less than 24 kg, it is recommended to use the preparation in the form of an oral suspension. For children weighing 6-11 kg: 25 mg twice a day, children weighing 2-12 kg: 23 mg twice a day. Children weighing 50-2 kg: 24 mg twice daily. Take the tablets in the morning and in the evening, every 40 hours.

Rulid in the form of film-coated tablets: the film-coated tablets should be swallowed whole with a sufficient amount of water. The tablets should be taken before a meal.

Preparation in the form of tablets for the preparation of an oral suspension: depending on the recommended dose, half a tablet or the entire tablet should be placed on a tablespoon with water, wait 30-40 seconds, during which the tablet will crumble to form a suspension ready for consumption, and then swallow the obtained suspension . Drink with water. The preparation should be taken before a meal.

Note:

1. Rulid is not recommended for use in people with severe hepatic insufficiency (e.g. cirrhosis with jaundice and / or ascites). However, if the doctor considers the use of Rulid necessary, then he or she will recommend an appropriate dose reduction and regular monitoring of liver function parameters. If liver function deteriorates, the doctor will consider discontinuing the preparation.
2. Liver function parameters should also be regularly monitored in people with liver dysfunction and in those who have had liver problems in the past in connection with the use of macrolide antibiotics.
3. No dosage adjustment is necessary in people with renal insufficiency.
4. Rulid may cause side effects such as dizziness and confusion, which may affect the ability to drive vehicles and use machines / machines.
5. Patients with glucose-galactose malabsorption should not use this preparation because it contains glucose.
6. Pregnant women should consult a doctor before use.
7. The roxithromycin in Rulid passes into breast milk. If the doctor considers it necessary to use the drug, it is recommended to stop breastfeeding.

Rulid – interactions

Be sure to inform your doctor if you are taking the following preparations:

1. benzodiazepine derivatives (e.g. midazolam, alprazolam, trazolam);
2. cyclosporine and bromocriptine;
3. anticoagulants such as, e.g., warfarin, acenocoumarol, phenprocoumon;
4. theophylline;
5. ergot alkaloids (ergotamine, dihydroergotamine);
6. astemizol, cyzapryd, pimozyd, terfenadyna;
7. drugs that can prolong the QT interval on the ECG (including antiarrhythmic drugs such as disopyramide, quinidine, procainamide, amiodarone);
8. digoxin and other cardiac glycosides.

Rulid and possible side effects

Taking Rulid may cause, among other things: vomiting, diarrhea, constipation, abdominal pain, flatulence, digestive disorders, anorexia, pseudomembranous enteritis (including diarrhea), increased liver enzymes or increased bilirubin, dyspnoea, bronchospasm, bronchial asthma, anaphylactic shock a also, severe skin reactions such as erythema multiforme, Stevens-Johnson syndrome, toxic necrosis.