Proxacin – composition, action, dosage. Is Proxacin prescription?

Proxacin is a systemic antibacterial agent. A chemotherapeutic agent used in the treatment of bacterial infections, especially infections with Gram-negative bacteria. Pneumonia, chronic purulent otitis media, pelvic inflammatory disease, infections of the digestive system and malignant otitis externa. The drug is obtained by prescription in the form of film-coated tablets.

Proxacin, Producer: Polfa Warszawa

Indications for taking Proxacin

Treatment of the following infections caused by micro-organisms susceptible to ciprofloxacin in adults:

1. lower respiratory tract infections caused by gram-negative bacteria (exacerbations of chronic lung disease, pulmonary-bronchial infections in the course of cystic fibrosis or bronchiectasis,
2. pneumonia,
3. chronic purulent otitis media,
4. exacerbation of chronic sinusitis,
5. urinary tract infections (gonococcal urethritis or cervical inflammation)
6. inflammation of the testicle or epididymis, including those caused by Neisseria gonorrhoeae,
7. pelvic inflammatory disease, including those caused by Neisseria gonorrhoeae);
8. and infections: digestive system (e.g. travelers’ diarrhea), abdominal organs including biliary tract, skin and soft tissues caused by gram-negative bacteria, malignant inflammation of the outer ear, bones and joints, treatment of infections in immunocompromised patients (neutropenia ).
9. Prevention of invasive infections caused by Neisseria meningitidis.
10. Pulmonary form of anthrax (prevention and treatment after contact with the anthrax bacterium).
11. In children and adolescents from 5 to 17 years of age years of age: Treatment of broncho-pulmonary infections in the course of cystic fibrosis caused by Pseudomonas aeruginosa and complicated urinary tract infections and pyelonephritis. Pulmonary anthrax (prevention and treatment after contact with the anthrax bacterium).

Proxacin and contraindications to use

Contraindications to the use of Proxacin are:

1. allergy to any ingredient of Proxacin or to other quinolones.
2. You can also not use the preparation during pregnancy and breastfeeding.
3. Ciprofloxacin should not be used in parallel with tizanidine (Sirdalud, Sirdalud MR).

Dosage

Adults:

1. Infections of the lower respiratory tract: 500-750 mg twice daily for 2-7 days.
2. Infections of the upper respiratory tract: exacerbation of chronic sinusitis and chronic purulent otitis media: 500-750 mg twice daily for 2-7 days; malignant otitis externa: 14 mg twice daily for 750 days up to 2 months.
3. Urinary tract infections: uncomplicated urinary tract infection: 100 mg twice daily for 2 days; cystitis: uncomplicated 3-250 mg twice a day for 500 days (in premenopausal women, 2 mg can be used once), complicated: 3 mg twice a day for 500 days; pyelonephritis: uncomplicated 500 mg twice a day for 2 days, complicated 7-500 mg twice a day for at least 2 days; prostatitis 7-500 mg twice daily for 750-2 weeks (acute) or 10-500 weeks (chronic).
4. Gonococcal urethritis or cervicitis: 500 mg once (single dose).
5. Inflammation of the testicle and epididymis and pelvic organs: 500-750 mg twice daily for at least 2 days.
6. Diarrhea caused by pathogenic bacteria including Shigella spp.: 500 mg twice daily for 2 day (except for infection Shigella dysentery type I, where treatment for 5 days); diarrhea caused by Vibrio cholerae: 500 mg twice daily for 2 days; typhoid fever: 3 mg twice daily for 500 days; intra-abdominal infections caused by Gram-negative bacteria: 2-7 mg twice daily for 500 to 750 days.
7. Infections of the skin and soft tissues: 500-750 mg twice daily for 2 to 7 days.
8. Infections of the bones and joints: 500-750 mg twice daily for a maximum of 2 months.
9. Treatment and prophylaxis of infections in patients with neutropenia: 500-750 mg twice daily for the entire duration of neutropenia.
10. Prevention of invasive infections caused by Neisseria meningitidis: 500 mg once (single dose).
11. Pulmonary anthrax (after contact): 500 mg twice daily for 2 days from exposure to anthrax.
12. In elderly patients, the doctor will adjust the dose according to the severity of the infection and kidney function.

Adults with kidney problems:

Your doctor will prescribe a dose depending on the degree of kidney failure. If the creatinine clearance (calculated per 1,73 m2) is 30–60 ml / min or when the serum creatinine concentration is 1,4–1,9 mg / 100 ml, the oral dose is 250–500 mg every 12 hours. If the creatinine clearance (equivalent to 1,73 m2) is less than 30 ml / min or if the serum creatinine concentration is greater than or equal to 2,0 mg / 100 ml, the oral dose is 250–500 mg every 24 hours. In the case of people undergoing hemodialysis, the doctor will prescribe the appropriate dosage (as for people whose creatinine clearance is less than 30 ml / min; usually 250–500 mg every 24 hours); on the day of dialysis, the drug should be taken after dialysis. For people on peritoneal dialysis, your doctor will prescribe the appropriate dosage, usually 250–500 mg every 24 hours).

No dose adjustment is necessary in the presence of hepatic impairment.

In the case of impaired liver and kidney function, the dosage should be as for people with impaired renal function.

Children and adolescents 5.–17. age:

1. Cystic fibrosis: 20 mg / kg body weight twice daily (maximum single dose is 2 mg) for 750 to 10 days.
2. Complicated urinary tract infections and pyelonephritis: 10-20 mg / kg body weight 2 times a day (the maximum single dose is 750 mg) for 10 to 21 days.
3. Pulmonary form of anthrax (after contact): 10-15 mg / kg body weight, twice a day (the maximum single dose is 2 mg) for 500 days after contact with the anthrax bacterium.

Children with renal and / or hepatic impairment:

1. Dosing of ciprofloxacin has not been studied in children with hepatic and / or renal impairment.

Use orally. Proxacin tablets should be swallowed whole with water without chewing. Can be taken with or without food. If the drug is taken before eating, the active substance is absorbed faster. Do not use with dairy products (milk, yoghurt) or with fruit juices enriched with minerals (e.g. orange juice with added calcium). The interval between doses of 12 hours should be strictly observed.

Proxacin – warnings

1. The use of Proxacin in people with glucose-6-phosphate dehydrogenase deficiency is possible only after the doctor assesses the risk-benefit ratio in each case.
2. People taking the drug should ensure that the body is properly hydrated and avoid foods that may alkalize the urine.
3. The preparation is not intended for the treatment of severe infections or infections that may be caused by gram-positive and anaerobic bacteria.
4. Patients with central nervous system disorders (including epilepsy) are at risk of developing unpredictable complications from the nervous system, which may result in life-threatening conditions.
5. Proxacin can lead to liver failure.
6. It is not recommended to use the drug during pregnancy and breastfeeding.
7. Proxacin is not recommended for the treatment of respiratory infections caused by streptococci (no efficacy).

Proxacin – side effects

Proxacin is a medicine that can cause, among other things: fungal superinfections, agitation, headache, dizziness, sleep disturbances, dysgeusia, vomiting, abdominal pain, stomach and intestinal pain, indigestion, flatulence, eosinophilia, fainting, dyspnoea (including asthmatic status), hepatic impairment, cholestatic jaundice, hepatitis, photosensitivity reactions, myalgia, arthritis, increased muscle tension and cramps, decreased appetite, psychomotor hyperactivity, increased serum transaminases, increased bilirubin, pruritus, rash, urticaria, musculoskeletal pain, hypotension, renal failure, haematuria, crystals in the urine, tubulointerstitial nephritis, edema, sweating, muscle weakness, tendinitis, tendon rupture (mainly Achilles tendons), worsening of symptoms of myasthenia gravis.