Pomegranates contain substances that affect the absorption of certain drugs and their transport into the cells. Why is this happening and what are the drugs?
Scientists from the University of Sydney investigated how the 3 main active substances in pomegranate – oleanolic, ursolic and gallic acids – affect drug delivery via solute carrier (SLC).
SLCs play a key role in the transport of molecules (e.g., hormones) across cell membranes as well as in the absorption and distribution of drugs. They also help in the transport of toxic substances to the kidneys and liver.
The pomegranates were chosen not by chance – these fruits contain acids that are also common in many other foods and drinks. For example – oleanolic and ursolic acids in dicotyledons, and gallic acid in tea, grapes or wine.
It turned out that the 3 previously mentioned pomegranate ingredients affect SLC, which means that if any other molecules enter the cells thanks to these transporters, the presence of active substances in the fruit will adversely affect this process.
SLC is used by, among others cholesterol-lowering statins or paclitaxel and methotrexate used in oncology.
Based on: Pharmaceutical Biology / ABC News / KopalniaWiedzy
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