Polopiryna C

Polopyrin C is a drug used for pain of low and moderate intensity (e.g. headache, muscle pain, joint pain and fever). It is a preparation with analgesic, antipyretic and anti-inflammatory properties, as well as inhibiting platelet aggregation. Polopyrin C contains a non-steroidal anti-inflammatory drug and vitamin C, which is needed for many metabolic changes. The effect of the drug lasts 3-6 hours after taking it.

Polopiryna C (Polpharma)

SUBSTANCE 1 tablet contains: 0,5 g of acetylsalicylic acid, 0,2 g of ascorbic acid

Polopyrin C action

Polopyrin C is a combined preparation with analgesic, antipyretic and anti-inflammatory properties. It contains acetylsalicylic acid and ascorbic acid-vitamin C. The analgesic and antipyretic effect of effervescent tablets begins after half an hour after taking it and lasts 3-6 hours.

Polopyrin C indications for the use of the drug

Polopyrin C is a drug intended to relieve pain of low or moderate intensity:

1. headaches,
2. muscle aches,
3. arthralgia,
4. pains accompanying fever during viral infections.

Polopyrin C is in the form of effervescent tablets and should be used as prescribed. Dissolve the drug in 0,75 glasses of water and drink the suspension. The preparation should be taken with a meal. Do not use for more than 3 days without medical consultation.

Dosage

1. Low to moderate pain, e.g. headache, muscle pain, joint pain, fever. Adults. Usually 1-2 tablets. 2-3 × / d. A dose of max. 3 g / d of acetylsalicylic acid.
2. Youth after 12 years of age 1-2 tablets / day

Polopyrin C and contraindications

Contraindications to taking Polopyrin C are:

1. hypersensitivity to any of the ingredients or other non-steroidal anti-inflammatory drugs,
2. blood coagulation disorders,
3. parallel use of anticoagulants,
4. active gastric and / or duodenal ulcer disease,
5. inflammation or bleeding from the gastrointestinal tract,
6. severe liver or kidney failure, c
7. heart failure
8. glucose-6-phosphate dehydrogenase deficiency,
9. bronchial asthma,
10. chronic respiratory diseases,
11. hay fever
12. swelling of the nasal mucosa,
13. pregnancy,
14. the period of breastfeeding,
15. parallel use of methotrexate at a dose of 15 mg / week or more.
16. do not use in children up to 12 years of age, especially in the course of viral infections.

Polopyrin C – warnings

1. Symptomatic treatment without medical advice can be carried out for no more than 3 days.
2. Do not use in patients taking oral antidiabetic drugs from the sulfonylurea group due to the risk of increased hypoglycaemic effect and in patients taking drugs used to treat gout.
3. Caution should be exercised when using the preparation in patients with impaired renal function and chronic renal failure.
4. In patients with juvenile rheumatoid arthritis and / or systemic lupus erythematosus and liver failure, the preparation should be used with caution because the toxicity of salicylates increases; in these patients liver function should be monitored.
5. Taking the lowest effective dose for the shortest time necessary to relieve symptoms reduces the risk of side effects.
6. Acetylsalicylic acid should be discontinued 5 to 7 days before elective surgery due to the risk of prolonged bleeding time, both during and after surgery.
7. Caution should be exercised when using methotrexate in doses lower than 15 mg / week, due to the increased toxicity of methotrexate on the bone marrow. Concomitant use with methotrexate in doses greater than 15 mg / week is contraindicated.
8. Use with caution in the case of vaginal haemorrhages, excessive menstrual bleeding, the use of an intrauterine contraceptive device, arterial hypertension and heart failure.
9. Alcohol should not be consumed during treatment with acetylsalicylic acid due to the increased risk of damage to the gastrointestinal mucosa.
10. Elderly patients should be used in lower doses and at greater intervals, due to the increased risk of side effects in this patient group.
11. Patients on a dietary control of sodium should take into account the sodium content of the drug (356 mg per tablet).
12. The preparation belongs to a group of drugs that may adversely affect female fertility. This effect is transient and disappears after the end of therapy.
13. The ascorbic acid contained in the preparation may affect the results of some laboratory tests.

Polopyrin C with other drugs

1. Acetylsalicylic acid reduces the antihypertensive effect of angiotensin converting enzyme inhibitors, may reduce the effectiveness of diuretics and increase the ototoxicity of furosemide.
2. Acetylsalicylic acid can significantly increase the concentration and thus toxicity of acetazolamide.
3. Concomitant use of acetylsalicylic acid and anticoagulants (e.g. heparin, warfarin) may increase the anticoagulant effect.
4. Acetylsalicylic acid may displace warfarin from protein junctions (leading to prolongation of prothrombin time and bleeding time) and increase the anticoagulant effect of heparin, thereby increasing the risk of bleeding. It may also potentiate the effects of thrombolytic drugs such as streptokinase and alteplase.
5. Acetylsalicylic acid enhances the toxic effect of valproic acid, and valproic acid enhances the anti-aggregating effect of acetylsalicylic acid.
6. Acetylsalicylic acid increases the toxicity of methotrexate on the bone marrow; acetylsalicylic acid should not be used concomitantly with methotrexate at doses of 15 mg per week or more; the concomitant use of methotrexate in doses less than 15 mg per week requires special care.
7. Concomitant use of acetylsalicylic acid and non-steroidal anti-inflammatory drugs is not recommended due to the increased risk of gastrointestinal side effects.
8. Systemic glucocorticosteroids (except hydrocortisone as replacement therapy in Addison’s disease) when administered concomitantly with acetylsalicylic acid increase the risk of peptic ulcer disease and gastrointestinal bleeding, and reduce plasma salicylate levels during therapy, and after treatment, the risk of salicylate overdose increases.
9. Acetylsalicylic acid enhances the hypoglycaemic effect of antidiabetic drugs.
10. Do not use simultaneously with sulfonylureas.
11. Salicylates reduce the effect of uricosuric drugs (e.g. probenecid, sulfinpyrazone); do not use simultaneously with anti-gout medications.
12. Acetylsalicylic acid may potentiate the effect of digoxin.
13. Alcohol increases the frequency and severity of gastrointestinal bleeding caused by acetylsalicylic acid.
14. You should not drink alcohol during treatment.
15. Omeprazole and ascorbic acid do not affect the absorption of acetylsalicylic acid.

Polopyrin c – side effects

1. The following may occur: indigestion, heartburn, epigastric fullness, nausea, vomiting, anorexia, abdominal pain, gastrointestinal bleeding, damage to the gastric mucosa, activation of ulcer disease, perforation (gastric ulceration occurs in 15% of patients on long-term acetylsalicylic acid treatment) , focal hepatic cell necrosis, liver tenderness and enlargement, especially in patients with juvenile rheumatoid arthritis, systemic lupus erythematosus, rheumatic fever or a history of liver disease, transient increases in serum transaminases, alkaline phosphatase and bilirubin.
2. The following may occur: tinnitus (usually a symptom of overdose), hearing impairment, dizziness, kidney disorders (proteinuria, presence of leukocytes and erythrocytes in the urine, renal papillary necrosis, interstitial nephritis), heart failure, hypertension, flushing, thrombocytopenia, anemia due to gastrointestinal microhaemorrhage, haemolytic anemia in patients with glucose-6-phosphate dehydrogenase deficiency, leukopenia, agranulocytosis, eosinopenia, increased risk of bleeding, prolonged bleeding time, prolonged prothrombin time.
3. Possible hypersensitivity reactions: rash, urticaria, angioedema, bronchospasm, shock. Ascorbic acid can cause fatigue, a burning sensation behind the breastbone, insomnia, or sleepiness. Ascorbic acid reduces the pH of the urine, which facilitates the precipitation of urate, cystine or oxalate.