Polfergan – indications, action, contraindications

Proven content

Polfergan is a first-generation antihistamine drug containing the active substance promethazine hydrochloride. It has antiallergic, antiemetic, sedative and hypnotic properties. It can relieve motion sickness as it reduces vestibular excitation and inhibits labyrinthine action. Polfergan is available on prescription in the form of a brown syrup.

Polfergan – indications for use

It is used in the treatment of:

1. symptomatic in acute allergic skin reactions with severe itching,
2. in post-transfusion reactions,
3. nausea,
4. vomiting
5. dizziness
6. motion sickness,
7. short-term insomnia and anxiety,
8. and before and after surgery.

Polfergan – precautions

This drug should not be used useif you are allergic to phenothiazine derivatives or any of its ingredients: citric acid monohydrate, sodium benzoate (E 211), caramel, orange flavor enhancer, sodium gentinate, sucrose, purified water.

No apply him also:

1. if you suffer from depression of the central nervous system,
2. in a coma,
3. in the last trimester of pregnancy,
4. during breastfeeding,
5. in children up to 2 years of age,
6. in children and adolescents with symptoms of Reye’s syndrome,
7. during the use of MAO inhibitors and 14 days after their discontinuation.

Care during application must keep:

1. in patients with asthma, bronchitis, bronchodilation, as Polfergan may cause thickening of the lung secretions,
2. in patients with severe coronary artery disease,
3. in patients with narrow-angle glaucoma,
4. in patients with epilepsy,
5. in patients with liver and kidney failure,
6. in patients with a narrowing of the bladder neck,
7. in patients with obstruction of the duodenal pylorus.

Please note that while application Do not drive vehicles, operate machinery, or engage in any activity that requires your full concentration and good mobility. During promethazine treatment strong sunlight should be avoided.

Polfergan – interactions

Polfergan enhances the inhibitory effect of the central nervous system:

1. alcohol,
2. barbiturates,
3. sleeping pills,
4. tranquilizers,
5. other antihistamines
6. tricyclic antidepressants.

Increases the effect of anticholinergic and antihypertensive drugs. May cause false positive or negative pregnancy test results. May cause false negative test results.

Polfergan – dosage

This drug should always be taken use as directed by your doctor. Check with your doctor or pharmacist if you are not sure.

Polfergan – side effects

Like any drug, this drug can cause side effectsalthough not everyone will experience them. The most common possible side effects: drowsiness; dizziness; anxiety; headaches; nightmares; fatigue and confusion. Anticholinergic side effectssuch as blurred vision, dry mouth and urinary retention are sporadic. For anticholinergic activity promethazine infants are susceptible. In children promethazine may paradoxically cause hyperactivity.

The elderly are especially susceptible to anticholinergics side effects of promethazine, may make them confused.

Other side effects include: hives; rash; itching; lack of appetite; stomach irritation; palpitations; arterial hypotension; Heart arythmia; extrapyramidal symptoms (muscle stiffness, poor facial expressions, restlessness, involuntary movements); muscle spasms and single involuntary movements of the head and face. For rare (affects 1 to 10 in 10 people) side effects include: anaphylaxis (a type of allergic reaction occurring immediately after administration of an allergic agent, such as malaise, paleness, severe anxiety, feeling of pressure and headache, tinnitus, vomiting, diarrhea, loss of consciousness); jaundice and blood disorders including hemolytic anemia.

Photosensitivity reactions have also been reported.