Used in pain of various etiologies and fever.
Paracetamol Polfarmex (Polfarmex)
| form, dose, packaging | availability category | the active substance |
| tabl. 0,5 g (10 tabl.) | OTC (over-the-counter) | paracetamol (paracetamol) |
ACTION
Non-opioid drug with analgesic and antipyretic properties
INDICATIONS AND DOSAGE
Pains of various etiology. Fever. Adults and children over 12 years of age. Orally. On an ad hoc basis, 0,5–1 g, usually 0,5 g 3–4 × / day. In chronic pain, 0,5–0,75 g every 4-6 h, usually 2 g / day. During short-term use, the maximum dose is 4 g / day, and in long-term use – 2,6 g / day.
CONTRAINDICATIONS
Hypersensitivity to paracetamol, severe liver or kidney failure, viral hepatitis, alcoholism.
WARNINGS
Do not use the preparation in children under 12 years of age. Do not use more than 10 days for the treatment of pain without consulting a doctor, 2 days for the treatment of a sore throat, 3 days for the treatment of fever. In order to avoid overdose, check that other taken preparations do not contain paracetamol. Do not exceed the recommended doses. Caution should be exercised when using the drug in patients with glucose-6-phosphate dehydrogenase deficiency, impaired liver or kidney function, patients with asthma, allergic to acetylsalicylic acid. The consumption of alcohol or the use of barbiturates (e.g. phenobarbital) or rifampicin increases the risk of hepatotoxicity. The risk of liver damage is particularly high in fasting people (e.g. those following restrictive diets). Use of the preparation in pregnant and breastfeeding women only after consulting a doctor and only if absolutely necessary.
INTERACTIONS
Paracetamol enhances the effect of coumarin derivative anticoagulants. Salicylamide increases the elimination time of paracetamol. Do not use with MAO inhibitors or within 14 days of stopping treatment with these drugs due to the possibility of agitation and high fever. The use of drugs that increase hepatic metabolism, such as rifampicin, antiepileptic drugs (phenobarbital, phenytoin, carbamazepine), some sleeping pills or alcohol consumption may cause toxic liver damage, even when using the recommended doses of paracetamol. The use of paracetamol and non-steroidal anti-inflammatory drugs increases the risk of renal dysfunction. Phenytoin may reduce the effectiveness of paracetamol and increase the risk of liver toxicity. Probenecid, cimetidine, antipyrine, isoniazid, ranitidine, propranolol prolong the duration of action of paracetamol. Metoclopramide accelerates the absorption of paracetamol; caffeine enhances its analgesic effect. Take caution when administering isoniazid or zidovudine. The use of paracetamol may affect the results of laboratory tests, for example, the determination of blood glucose or uric acid levels.
SIDE EFFECTS
The following may occur: nausea, vomiting, pancreatitis, liver damage with or without jaundice, impaired liver and / or kidney function (renal colic, pyuria), thrombocytopenia, agranulocytosis, methaemoglobinaemia. Rare: laryngeal edema, angioedema, urticaria, bronchospasm, other hypersensitivity reactions.