Used in pain of various etiologies, fever in the course of colds and flu-like conditions.
Paracetamol – Herbapol Wrocław (Herbapol Wrocław)
| form, dose, packaging | availability category | the active substance |
| tabl. 0,5 g (6 tabl., 10 tabl., 30 tabl.) | OTC (over-the-counter) | paracetamol (paracetamol) |
ACTION
Non-opioid drug with analgesic and antipyretic properties
INDICATIONS AND DOSAGE
Pains of various etiology. Fever in the course of colds and flu-like conditions. Orally, tabl. can be shared. Adults. 1-2 tablets every 4-6 h. The maximum dose during short-term treatment is 4 g / day, and during long-term treatment – 2,6 g / day. Children 6-12 years old 10-15 mg / kg bw. every 4–6 h up to 4 × / day; max. 65 mg / kg b.w./d.
CONTRAINDICATIONS
Hypersensitivity to any component of the preparation, severe renal or hepatic dysfunction, alcoholism.
WARNINGS
Do not use for more than 10 days in adults and not more than 3 days in children without a doctor’s recommendation. In order to avoid overdose, check that other taken preparations do not contain paracetamol. Do not exceed the recommended doses. Caution should be exercised when using the drug in patients with glucose-6-phosphate dehydrogenase deficiency, with impaired liver or kidney function. Do not drink alcohol during the treatment period due to the risk of toxic liver damage. The risk of liver damage is particularly high in people who are fasting (e.g. following restrictive diets) or abusing alcohol. Use of the preparation in pregnant and breastfeeding women only after consulting a doctor and only if absolutely necessary.
INTERACTIONS
Paracetamol enhances the effect of coumarin and indanedione anticoagulants (risk of bleeding). Salicylamide increases the elimination time of paracetamol. Do not use with MAO inhibitors or within 14 days from the end of treatment with these preparations due to the possibility of agitation and high fever. The use of drugs that increase hepatic metabolism, such as rifampicin, antiepileptics (phenobarbital, phenytoin, carbamazepine), some sleeping pills or alcohol consumption may cause liver toxicity, even when using the recommended doses of paracetamol. The use of paracetamol and non-steroidal anti-inflammatory drugs increases the risk of renal dysfunction. Phenytoin may reduce the effectiveness of paracetamol and increase the risk of liver toxicity. Metoclopramide accelerates absorption, and cholinolytic drugs delay the absorption of paracetamol; caffeine and paracetamol intensify each other’s effects. Take caution when administering isoniazid or zidovudine. The use of paracetamol may affect the results of laboratory tests, for example, the determination of blood glucose or uric acid levels.
SIDE EFFECTS
The following may occur: nausea, vomiting, diarrhea, abdominal pain, headache, drowsiness, liver damage with or without jaundice, impaired liver and / or kidney function (renal colic, pyuria), itching, urticaria, rash, erythema. Very rare: thrombocytopenia, agranulocytosis, methaemoglobinaemia.