The drug is used in pain of various origins, fever, symptomatic treatment of flu-like conditions and colds.
Panadol Extra (GlaxoSmithKline Consumer Healthcare)
| form, dose, packaging | availability category | the active substance |
| tabl. bowl. (12 tabl., 24 tabl.) | OTC (over-the-counter) | kofeina, paracetamol (caffeine, paracetamol) |
SUBSTANCE 1 tablet contains: 0,5 g of paracetamol, 0,065 g of caffeine
ACTION
Combined preparation with analgesic and antipyretic properties
INDICATIONS AND DOSAGE
Pains of various origins, fever, symptomatic treatment of flu-like conditions and colds. Adults and children over 12 years of age orally 1-2 tablets. not more frequently than every 4 h. Do not exceed the dose of 8 tablets / day.
CONTRAINDICATIONS
Hypersensitivity to paracetamol or caffeine, severe liver or kidney failure, glucose-6-phosphate dehydrogenase deficiency, alcoholism, 12st trimester of pregnancy, cardiac arrhythmias, hypertension, insomnia. Do not use in parallel with other drugs containing paracetamol. Do not give to children under XNUMX years of age.
WARNINGS
Use of the preparation during pregnancy and breastfeeding only after consulting a doctor and only if absolutely necessary. The use of the drug in the first trimester of pregnancy is contraindicated. Do not use doses higher than recommended. In order to avoid overdose, check that other medications do not contain paracetamol. The use of the preparation by people with hepatic insufficiency, alcohol abuse and starvation increases the risk of liver damage. Use with caution in people with renal, hepatic or bronchial asthma. Do not drink alcohol while using the preparation. People who drink large amounts of coffee or tea while using the preparation may feel tense and irritable.
INTERACTIONS
Do not use with other drugs containing paracetamol. Paracetamol may increase the effect of anticoagulants (warfarin, coumarin). Concomitant administration with rifampicin, antiepileptic drugs or hypnotics (e.g. phenobarbital, phenytoin, carbamazepine) and other drugs inducing liver microsomal enzymes increases the risk of liver damage. Paracetamol administered with MAO inhibitors may cause agitation and high fever. Paracetamol enhances the central effect of caffeine. Caffeine enhances the analgesic effect of paracetamol. Caffeine may reduce the effect of sleeping pills and antiepileptic drugs. Oral contraceptives, cimetidine, reduce caffeine metabolism, while barbiturates and smoking accelerate it. Metoclopramide accelerates, and cholinolytics delay the absorption of paracetamol from the gastrointestinal tract. The combined administration of paracetamol and non-steroidal anti-inflammatory drugs increases the risk of renal dysfunction. Salicylamide increases the elimination time of paracetamol.
SIDE EFFECTS
The following may occur: nausea, vomiting, digestive disorders, allergic reactions (urticaria, erythema, rash). Isolated cases of haematological disorders (thrombocytopenia, agranulocytosis, methaemoglobinaemia). Due to the caffeine content in the preparation, the following may occur: sleep disturbances, headaches, muscle tremors, heart rhythm disturbances. Liver or kidney damage usually occurs after overdose.