Ospen – indications, contraindications, composition, side effects

important

If a patient is diagnosed with an acute phase of infection (e.g. sepsis, pericarditis or endocarditis, osteomyelitis), your doctor may recommend parenteral penicillin administration.

Attention

If severe and persistent diarrhea occurs during or after treatment with Ospen, do not use medications that inhibit intestinal peristalsis. In such a situation, patients are advised to consult a physician.

important

The duration of treatment with Ospen is determined by the doctor. General recommendations are to use the preparation for 3 days after symptoms disappear. In the case of streptococcal infections, antibiotics are usually taken for a minimum of 10 days.

Detailed information about possible side effects of Ospen is included in the product leaflet.

Nosological classification (ICD-10)

List of ICD-10 codes

1 tablet contains phenoxymethylpenicillin (as potassium salt) 250 mg; in a cardboard box 50 blisters of 20 pcs.

1 coated tablet – 500,000, 1,000,000 and 1,500,000 IU; in a box of 100 blisters of 10 pcs. or 2 blisters of 6 pcs. (respectively).

5 ml (1 scoop) granules for oral suspension – benzathine phenoxymethylpenicillin 400,000 IU / 5 ml (corresponding to 250 mg phenoxymethylpenicillin); in bottles with a capacity of 60 ml, complete with a measuring spoon, in a box 1 set.

5 ml syrup – benzathine phenoxymethylpenicillin 400,000 or 750,000 IU; in bottles with a capacity of 60 ml, complete with a measuring spoon, in a box 1 set.

Pharmachologic effect

Suppresses the biosynthesis of the bacterial cell wall.

Active against streptococci of groups A, C, G, H, L, M, Streptococcus pneumoniae, staphylococci that do not produce penicillinase, Neisseriae, Erysipelothrix rhusiopathiae, Listeriae, Corynebacterium, Bacillus anthracis, actinomycetes, streptobacilli, Pasteurella multocida, Spirillum minus, spirochetes ( Leptospira, Treponema, Borrelia, etc.), anaerobes (Peptococci, Peptostreptococci, Fusobacteria, Clostridia). Among enterococci (group D streptococci), sensitivity is noted only among some strains.

Well absorbed, not inactivated by gastric juice. Cmax , providing a therapeutic effect, is achieved after 30-60 minutes, T _1/2 –  30-45 minutes. 55% binds to plasma proteins. Easily penetrates into tissues (kidneys, lungs, skin, mucous membranes, muscles, etc.). It is excreted by the kidneys in unchanged form, a small part of the active ingredient is excreted in the bile. Passes through the placental barrier and penetrates into breast milk.

Infections of the respiratory tract (bronchitis, pneumonia), ENT organs (scarlet fever, tonsillitis, Vincent’s tonsillitis, pharyngitis, tonsillopharyngitis, purulent pharyngitis, acute otitis media, sinusitis), skin (erysipelas, pyoderma, including contagious impetigo, furunculosis, abscess, phlegmon, chronic migratory erythema and other clinical signs of Lyme disease, infected wounds and burns); prevention of streptococcal infections and their complications (rheumatic attack, polyarthritis, endocarditis, glomerulonephritis, etc.), bacterial endocarditis in patients with congenital or acquired rheumatic heart disease before and after minor surgical interventions, pneumococcal infections in children with sickle cell anemia.

Hypersensitivity to beta-lactam antibiotics or to the excipients that make up the drug, gastrointestinal diseases , accompanied by persistent diarrhea and vomiting.

Perhaps if the expected effect of therapy outweighs the potential risk to the fetus or newborn.

Inside, 30 minutes before meals, adults 500 mg (for mild to moderate infections), 750 mg (for severe) 3-4 times a day for 7-10 days. Children from 1 to 6 years old – 250 mg 3 times a day, 6-12 years old – 500 mg 3 times a day.

Ospen 750 syrup: children 1-6 years old (10-22 kg) – 1/2 scoop 3 times a day, 6-12 years old (22-38 kg) – 1 scoop 3 times a day, adolescents and adults – 2 measuring spoons 3 times a day; if necessary, increase the dose. The daily dose for adults and children over 12 years old is 3-4.5 million IU, for children from 1 to 12 years old – 50,000-100,000 IU / kg (in 2-3 doses). The minimum pediatric dose is 25,000 IU/kg, the maximum adult dose is 6 million IU.

Treatment is continued for 3 days after the symptoms disappear, to prevent complications in patients with streptococcal infections, the duration of the course is at least 10 days.

On the part of the digestive tract: nausea, diarrhea, vomiting, feeling of stomach fullness, stomatitis, glossitis, pseudomembranous colitis.

From the side of the cardiovascular system and blood (hematopoiesis, hemostasis): hemolytic anemia, leuko-, thrombocytopenia, agranulocytosis, eosinophilia, positive direct Coombs test.

Allergic reactions: urticaria, angioedema, erythema multiforme, exfoliative dermatitis, anaphylactic shock, collapse and other anaphylactoid reactions.

Other: fever, joint pain.

When combined with allopurinol, phenylbutazone, NSAIDs , calcium secretion decreases and the concentration of phenoxymethylpenicillin increases. Increases the effectiveness of anticoagulants by suppressing the intestinal microflora and lowering the prothrombin index, weakens the effect of oral contraceptives taken. Incompatible with bacteriostatic antibiotics. With the simultaneous administration of ethinylestradiol and drugs, during the metabolism of which PABA is formed , there is a risk of breakthrough bleeding. Simultaneous use of allopurinol increases the risk of developing allergic reactions. Antacids, glucosamine, laxatives, aminoglycosides slow down and reduce absorption; ascorbic acid – increases.

With the development of allergic reactions in patients, the drug should be discontinued. In case of suspected staphylococcal infections, bacteriological studies are recommended. Before carrying out planned surgical interventions (tonsillectomy, tooth extraction, etc.), in the postoperative period in patients receiving penicillin for the purpose of antirheumatic prophylaxis, it is necessary to double the dose. During therapy, it is recommended to monitor the composition of the blood, liver and / or kidney function. With long-term treatment, the potential for the growth of resistant strains of microorganisms, fungi and pseudomembranous colitis should be borne in mind (the drug should be discontinued and, based on the results of bacteriological examination, appropriate treatment should be prescribed; antiperistaltic drugs are contraindicated). In patients with known hypersensitivity to cephalosporins, a possible cross-allergy should be borne in mind. In severe pneumonia, empyema, sepsis, pericarditis, meningitis, arthritis and osteomyelitis, in the acute stage, a transition to parenteral administration of the drug is necessary. In combination with other antibiotics with a proven synergistic effect, the dose of a more toxic drug may be reduced. In patients with anuria, the dose should be reduced or the interval between doses of the drug should be increased. Caution should be given to patients with allergic diathesis, bronchial asthma. In combination with other antibiotics with a proven synergistic effect, the dose of a more toxic drug may be reduced. In patients with anuria, the dose should be reduced or the interval between doses of the drug should be increased. Caution should be given to patients with allergic diathesis, bronchial asthma. In combination with other antibiotics with a proven synergistic effect, the dose of a more toxic drug may be reduced. In patients with anuria, the dose should be reduced or the interval between doses of the drug should be increased. Caution should be given to patients with allergic diathesis, bronchial asthma.

Patients with diabetes should take into account that synthetic saccharin is used in the manufacture of Ospen 750 syrup. During therapy, a false positive reaction is possible with a non-enzymatic determination of sugar in the urine and analysis for urobilinogen, as well as false positive results for the quantitative determination of amino acids in the urine by the ninhydrin method.