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Nivalin is a drug used in anesthesiology and surgery. It is used, among others in the treatment of postoperative atony of the urinary bladder and intestines, or in myasthenia gravis and myopathies. Nivalin is available as a solution for injection. What is worth knowing about Nivalin and when should you be particularly careful?
Nivalin’s task is to increase the contractility of skeletal muscles. It is administered to facilitate conduction in the nervous system and also causes smooth muscle contractions. The composition of Nivalin includes galantamine.
Nivalin – action
Galantamine contained in Nivalin is a selective, reversible inhibitor of acetylcholine esterase. This substance is designed to stimulate nicotinic receptors and increase the sensitivity of postsynaptic acetylcholine receptors.
The active substance of Nivalinu crosses the blood-brain barrier. Thanks to this, the preparation facilitates the conduction of stimuli in the CNS and intensifies the processes of stimulation. Nivalin increases the tension of smooth muscles, secretion of the gastrointestinal and sweat glands, and also causes the constriction of the pupils.
Nivalin – indications
The indication for the use of Nivalin is the treatment of symptoms of neuromuscular and spinal cord diseases.
Nivalin – contraindications
Hypersensitivity to any component of the preparation is a contraindication to the use of Nivalin. In addition, the drug should not be used in people with bronchial asthma, bradycardia, atrioventricular block, ischemic heart disease, severe heart failure, epilepsy, hyperkinesia, and severe renal or hepatic insufficiency.
Nivalin – precautions
People with sinus node syndrome and other supraventricular heart conduction disturbances, as well as people taking preparations significantly slowing the heart rhythm and decompensated electrolyte disturbances should be especially careful.
Nivalin may also induce seizures and aggravate the symptoms of Parkinson’s disease. The drug should also be used with caution in people with heart failure, urinary tract obstruction and after surgical excision of the prostate and bladder. It should not be used during surgery under general anesthesia.
It is also not recommended to use Nivalin during pregnancy and breastfeeding. The physician prescribing Nivalin should always be informed about other medications taken, as Nivalin may interact with other preparations. The drug may also affect your ability to drive and use machines.
Nivalin – side effects
The most common side effects include: bradycardia, atrioventricular block, stenocardia, palpitations, dizziness and headache, insomnia, severe watery eyes, rapid breathing, vomiting, diarrhea, excessive or poor appetite. Seizures may also occur.
Nivalin – dosage
Nivalin can be used subcutaneously, intramuscularly and intravenously. The amount of the dose and the length of treatment are always determined individually by the doctor. Depending on the age of the patient, this is usually:
- adults – 2,5 mg of Nivalin. The dose is increased every 3-4 days by 2,5 mg in 2-3 divided doses. A maximum of 10 mg can be administered subcutaneously at one time, and 20 mg throughout the day;
- children – Nivalin is administered subcutaneously. Between 1-2 years, 0,25-1 mg is administered, 3-5 years old 0,5-5 mg is administered, 6-8 years old 0,75-7,5 mg is administered, 9-11 years old is administered from 1 -10 mg, 12-15 years of age is administered from 1,25-12,5 mg, after 15 years of age 1,25-15 mg.
The treatment time is usually 40-60 days. Such cycles can be repeated 2-3 times every 1-2 months.
Before use, read the leaflet, which contains indications, contraindications, data on side effects and dosage as well as information on the use of the medicinal product, or consult your doctor or pharmacist, as each drug used improperly is a threat to your life or health.