Nebilet – composition, action, dosage, contraindications

Proven content

Nebilet is a prescription medicine. The active substance is nebivolol, which belongs to beta-blockers. It is used to reduce the heart rate and blood pressure.

Nebilet – characteristics and composition

Nebilet is a prescription medicine. The active substance of the drug is nebivolol, which belongs to the group of selective beta-blockers. Nebilet is used in the treatment of high blood pressure, heart failure and coronary artery disease.

Each tablet contains 5 mg nebivolol (as nebivolol hydrochloride): 2,5 mg SRRR-nebivolol (or d-nebivolol) and 2,5 mg RSSS-nebivolol (or l-nebivolol). The auxiliary substances are: lactose monohydrate, corn starch, croscarmellose sodium, hypromellose, polysorbate 80, microcrystalline cellulose, hydrated colloidal silica, magnesium stearate, purified water.

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Nebilet – action

Nebilet is a drug whose action is closely related to the presence of the active substance. Nebivolol is a beta-blocker that is responsible for blocking beta-adrenergic receptors. As a result, it reduces the effects of adrenaline or noradrenaline, which contributes to the reduction of the heart rate and the relaxation of peripheral blood vessels.

As nebivolol is selective for the beta 1 receptors in the heart, the risk of side effects related to peripheral effects (e.g. risk of airway obstruction) is reduced.

Nebilet – dosage

The dosage of the Nebilet is strictly defined. The Nebilat leaflet contains detailed information on how to take the medicine.

Hypertension

1. adults – the daily dose is 1 tablet (5 mg nebivolol). The blood pressure lowering effect becomes apparent after 1-2 weeks of treatment,
2. patients with renal insufficiency – the daily dose is 2,5 mg, if necessary, the dose can be increased to 5 mg (of course after consulting a doctor),
3. elderly people – for people over 65, the recommended daily dose is 2,5 mg, if necessary, the dose can be increased to 5 mg (of course after consulting a doctor). In turn, in people over 75 years of age, special care should be taken and patients should be carefully monitored.

Chronic heart failure

Treatment of stable chronic heart failure should begin with a gradual increase in the dose until the optimal maintenance dose is reached. Initial dose titration should follow the schedule below, at intervals of 1-2 weeks, according to patient tolerance: the 1,25 mg nebivolol dose should be increased to 2,5 mg nebivolol once daily, then to 5 mg once daily and up to 10 mg once a day sequentially. The maximum recommended dose is 10 mg nebivolol once daily.

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Nebilet – contraindications to use

The Nebilet leaflet informs about contraindications to use. The preparation is not recommended for:

1. hypersensitivity to any of the ingredients of the drug,
2. liver failure or liver dysfunction,
3. acute heart failure, cardiogenic shock,
4. second or third degree atrioventricular block,
5. sick sinus syndrome,
6. bradycardia,
7. arterial hypotension,
8. severe circulatory disorders
9. metabolic acidosis
10. severe chronic obstructive pulmonary disease,
11. an untreated tumor of the adrenal gland
12. pregnancy and breastfeeding.

Nebilet should not be taken by patients with hepatic insufficiency or hepatic impairment, as data on the use of the drug in this group of people are currently limited. The safety and efficacy of Nebilet in children and adolescents under 18 years of age have not been established. No data available. Therefore, the use of the product in children and adolescents is not recommended.

Nebilet – warnings

Warnings regarding the use of Nebilet:

1. in some cases, it is necessary to carry out certain control tests,
2. inform your doctor about taking the preparation if you plan any surgery that requires anesthesia,
3. treatment should not be stopped suddenly in people with ischemic heart disease,
4. the preparation may reduce the heart rate,
5. verapamil and diltiazem, class I antiarrhythmic drugs (phenytoin, quinidine, disopyramide, propafenone, lidocaine, flecainide), centrally acting antihypertensive drugs (e.g. clonidine) are not recommended,
6. in patients with diabetes it is possible to mask the symptoms of hypoglycaemia,
7. people with an increased risk of bronchospasm should exercise particular caution,
8. during the treatment, sensitivity to allergens and hypersensitivity may be increased,
9. the drug may reduce the production of tears.

Nebilet – drug interactions

Nebilet may interact with other medications. Therefore, it is absolutely necessary to inform the doctor about all the preparations taken, as well as planned procedures requiring anesthesia.

It is not recommended to use the Nebilet in parallel with:

1. class I antiarrhythmic drugs,
2. calcium antagonists,
3. centrally acting antihypertensive drugs.

In addition, caution should be exercised in, inter alia, when using:

1. preparations used for general anesthesia;
2. insulin and other oral anti-diabetic drugs;
3. non-steroidal anti-inflammatory drugs;
4. sympathomimetic drugs acting on alpha and beta receptors;
5. digitalis glycosides;
6. mefloquine.

The active substance nebivolol is also found in drugs such as Nedal, Nebilet, Daneb or Ebivol.

Nebilet – side effects

Taking Nebilet may be associated with certain side effects.

Common side effects include: worsening of heart failure (in the course of treatment of this disease), shortness of breath, diarrhea, constipation, nausea, fatigue.

It uncommonly occurs: hypotension, bradycardia, atrioventricular conduction disturbances, sleep disturbances, depression.

Very rare side effects include: worsening of psoriasis symptoms, fainting.

Before use, read the leaflet, which contains indications, contraindications, data on side effects and dosage as well as information on the use of the medicinal product, or consult your doctor or pharmacist, as each drug used improperly is a threat to your life or health. Do you need a medical consultation or an e-prescription? Go to halodoctor.pl, where you will get online help – quickly, safely and without leaving your home. Now you can use e-consultation also free of charge under the National Health Fund.