Natrax 100, -200 for pain of various origins. Composition and dosage

Natrax is a medicine used for pain of various origins, mild to moderate, such as headaches, toothaches, muscles, bones and joints, painful menstruation, fever of various origins and to relieve symptoms of colds and flu.

Natrax 100, -200 (Polfa Pabianice SA)

form, dose, packaging availability category the active substance
tabl. 0,1 g, 0,2 g (10 tabl.) OTC (over-the-counter) naproxen

Natrax action

Natrax is a non-steroidal anti-inflammatory drug that is derived from propionic acid

Natrax indications and dosage

Natrax is designed to relieve the pains of:

  1. head,
  2. teeth,
  3. muscles
  4. bones,
  5. joints,
  6. painful menstruation,
  7. fever

Dosage (Oral)

  1. Adults and children over 16 years of age 200 mg every 8-12 hours or 400 mg as the first dose, then 200 mg 12 hours later and 200 mg every 8-12 hours if necessary.
  2. In patients 16-65. years of age, the maximum dose – 600 mg / day, in patients over 65 years of age – 400 mg / day.

Natrax and contraindications

Contraindications to the use of Natrax are:

  1. hypersensitivity to any component of the preparation,
  2. hypersensitivity to other non-steroidal anti-inflammatory drugs (including acetylsalicylic acid) with symptoms of asthma, rhinitis, nasal polyps or urticaria,
  3. gastric and / or duodenal ulcer disease, active or in history, with or without gastrointestinal bleeding,
  4. severe liver, kidney or heart failure
  5. hemorrhagic diathesis,
  6. III trimester of pregnancy,
  7. the period of breastfeeding.

Natrax warnings

Natrax warnings

  1. The preparation without a prescription can be used by patients over 16 years of age.
  2. Do not exceed the recommended daily dose of the drug.
  3. Long-term patients should be monitored regularly due to the risk of side effects.
  4. In the elderly, the risk of side effects increases – it is recommended to use the lowest dose for the shortest possible time.
  5. Tell your doctor about any unusual gastrointestinal symptoms (especially bleeding), especially at the beginning of treatment. This is especially true for the elderly and people with gastrointestinal diseases.
  6. There is a risk of gastrointestinal haemorrhage or perforation, which may be fatal and may not necessarily be followed by warning symptoms.
  7. Due to the increased risk of serious side effects, the concomitant use of other preparations containing naproxen, other non-steroidal anti-inflammatory drugs (including selective COX-2 inhibitors), and glucocorticosteroids should be avoided.
  8. If there is a need to use low doses of acetylsalicylic acid or other ulcerogenic drugs at the same time, consult a physician who may consider co-treatment with protective drugs (e.g. misoprostol or proton pump inhibitors).
  9. It is necessary to be especially careful in people with gastrointestinal diseases (ulcerative colitis, Crohn’s disease), as the symptoms may worsen.
  10. People with renal disorders should use the drug with caution and only after medical consultation (in these patients, the plasma creatinine concentration and creatinine clearance should be periodically monitored; do not use naproxen if the creatinine clearance is less than 30 ml / minute); with hepatic impairment (naproxen can cause jaundice or hepatitis, sometimes fatal); with blood coagulation disorders (naproxen reduces platelet aggregation and prolongs bleeding time, which should be taken into account when determining the bleeding time).
  11. People with systemic lupus erythematosus and mixed connective tissue disease are at increased risk of developing aseptic meningitis.
  12. Patients with bronchial asthma or with symptoms of allergic reactions after taking acetylsalicylic acid (due to the risk of sudden bronchospasm), as well as people taking other medications (especially drugs that lower blood pressure, diuretics, cardiac and psychotropic or anticoagulants) should consult a doctor. before using naproxen.
  13. All visual disturbances and eye discomfort should be reported to your doctor.
  14. Long-term use of some non-steroidal anti-inflammatory drugs in high doses may increase the risk of heart attack or stroke; data on the use of low doses of naproxen (200-600 mg / day) are insufficient to establish their effect on the risk of blood clots.
  15. Careful monitoring of renal function before and during treatment is necessary in some patients (especially with a history of renal impairment, congestive heart failure, cirrhosis, the elderly or those taking diuretics; in these cases, medical consultation is recommended to determine reduced doses. daily).
  16. The use of non-steroidal anti-inflammatory drugs can cause renal failure.
  17. Serious hypersensitivity reactions (including severe skin reactions and anaphylactic reactions), some of them fatal, can occur.
  18. The use of the preparation should be discontinued at the first appearance of skin symptoms (e.g. rash, damage to the oral mucosa, etc.).
  19. Non-steroidal anti-inflammatory drugs may cause temporary impairment of fertility in women. It is not recommended for use in women in the first and second trimester of pregnancy. Use in the first and second trimesters of pregnancy only after consulting a doctor and only if absolutely necessary, when, in the doctor’s opinion, the benefit for the mother outweighs the potential risk for the fetus.
  20. It should not be used in the third trimester of pregnancy and during breastfeeding.
  21. Be careful when carrying out activities that require concentration.
  22. People driving motor vehicles should be especially careful because the drug may cause side effects that impair psychophysical fitness (drowsiness, dizziness and headaches, blurred vision, reduced ability to respond to external stimuli).
  23. The preparation contains lactose and should not be used by people with hereditary disorders of galactose intolerance, lactase deficiency or malabsorption of glucose-galactose.

Other Medicines and Natrax

Natrax should not be used together with the drugs listed below:

  1. acetylsalicylic acid or other antiplatelet drugs and antidepressants – the risk of gastrointestinal bleeding increases,
  2. diuretics – non-steroidal anti-inflammatory drugs may reduce the effectiveness of these drugs (e.g. furosemide) and increase the risk of hyperkalemia; antihypertensive drugs – non-steroidal anti-inflammatory drugs may reduce the effectiveness of these drugs (e.g. propranolol and other blockers) and increase the risk of renal failure associated with the use of angiotensin converting enzyme inhibitors,
  3. anticoagulants (warfarin, acenocoumarol, heparin) – non-steroidal anti-inflammatory drugs may increase the effect of anticoagulants and increase the risk of bleeding,
  4. sibutramine – the risk of bleeding increases; lithium, methotrexate and baclofen – non-steroidal anti-inflammatory drugs may increase their plasma concentration and thus increase their toxic effect,
  5. cardiac glycosides; cyclosporin or tacrolimus – the risk of nephrotoxicity increases,
  6. zidovudine – the bleeding period is longer,
  7. corticosteroids – the risk of gastrointestinal side effects (e.g. bleeding) increases,
  8. the use of antacids, cholestyramine or food intake may delay the absorption of naproxen, but it does not change the total amount absorbed.
  9. naproxen increases the risk of overdose symptoms of phenytoin, anticoagulants, and sulfonamides.
  10. Due to the potential for interactions between NSAIDs and anticoagulants and sulphonylureas, caution should be exercised.
  11. Non-steroidal anti-inflammatory drugs used within 8-12 days after administration of mifepristone may reduce its effectiveness.
  12. The use of non-steroidal anti-inflammatory drugs and quinolone drugs increases the risk of seizures. Testing of the adrenal function should be performed at least 48 hours after administration of naproxen as it may falsify the results of laboratory tests.

Natrax side effects

When taking Natrax, you may experience side effects.

  1. The following may occur: diarrhea, indigestion, abdominal pain, nausea, constipation, flatulence, heartburn, gastritis, peptic ulcer disease, gastrointestinal bleeding, haematemesis, melaena, skin rashes, itching, urticaria, angioedema, kidney failure, headache and dizziness, insomnia, drowsiness, agitation, irritability, in isolated cases tinnitus or psychotic reactions, convulsions.
  2. Occasional side effects include: respiratory reactions manifested by asthma, worsening of asthma, bronchospasm, or shortness of breath; swelling of the face, tongue, larynx; fatal anaphylactic shock; Heart arythmia; hypertension; heart failure, swelling, vasculitis; blurred vision; muscle pain or weakness; skin reactions in the form of toxic epidermal necrolysis, Stevens and Johnson syndrome, erythema multiforme, systemic lupus erythematosus, pemphigus, purpura, ecchymosis, hemorrhagic diathesis; porphyria; thrombocytopenia; agranulocytosis (the first symptoms are fever, sore throat, mouth ulcers, flu-like symptoms, epistaxis, bruising, ecchymosis, etc.); hemolytic or aplastic anemia; exacerbation of colitis and Crohn’s disease; inflammation of the pancreas; liver dysfunction, jaundice; Renal failure, decreased urine output, papillary necrosis, glomerulonephritis, increased plasma sodium levels, proteinuria, haematuria. Isolated cases of symptoms associated with aseptic meningitis have been reported in individuals with autoimmune diseases (e.g. lupus erythematosus). Long-term use of non-steroidal anti-inflammatory drugs in high doses may increase the risk of heart attack or stroke.

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