Contents
Mucosolvan syrup is a drug used in acute and chronic lung and bronchial diseases with difficulty expectoration of sticky secretions in the respiratory tract. Ambroxol contained in the preparation thins the residual secretion and reduces its viscosity. The drug is in the form of a syrup to be taken by mouth and is available without a prescription.
mucosolvan (Boehringer Ingelheim)
| form, dose, packaging | availability category | the active substance |
| syrup 0,006 g/ml (0,03 g/5 ml) (100 ml) | OTC (over-the-counter) | ambroxol (ambroxol) |
ACTION – Mukolityk
Mucosolvan syrup – indications and dosage
Mucosolvan syrup is a drug recommended for use in acute and chronic lung disease accompanied by difficult expectoration of sticky secretions in the respiratory tract.
Drug dosage
Mucosolvan is a syrup to be taken by mouth. Patients with renal insufficiency should reduce the dose of the drug. The preparation should be taken after meals.
- Adults and children after the age of 12 30 mg (5 ml) twice daily.
- Kids. 6.-12. years – 15 mg (2,5 ml) 2-3 times / day; 2.-6. years – 7,5 mg (1,25 ml) 3 times / day
- Children 1-2. years – 7,5 mg (1,25 ml) twice / day
Mucosolvan syrup and contraindications
Contraindication to the use of Mucosolvan syrup is allergy to any component of the drug.
Mucosolvan syrup – warnings about the drug
- It should be taken with caution in people with gastric or duodenal ulcers, weakened cough reflex or ciliary cleansing disorders, and in people with liver or kidney failure.
- Patients with bronchial asthma may be at risk of severe coughing due to the content of ambroxol.
- Mucosolvan syrup should not be taken overnight.
- Benzoic acid and propylene glycol contained in the drug may cause an allergic reaction.
- Glycerol and sorbitol in the syrup cause gastrointestinal diseases.
- The glycerol in the preparation may also cause headaches.
- Pregnant and breastfeeding women may take the drug only after consulting a doctor and if absolutely necessary.
- Women in the first trimester of pregnancy should exercise caution.
Mucosolvan syrup with other drugs
- Do not take Mucosolvan syrup together with antitussive preparations, e.g. codeine, because this reflex causes the removal of a large amount of secretion formed after liquefaction.
- Taking the drug simultaneously with antibiotics (amoxicillin, cefuroxime, doxycycline, erythromycin) increases their penetration into the lung tissue.
Mucosolvan syrup – side effects
While taking Mucosolvan, the syrup may appear:
- rare allergic reactions,
- skin and mucosal reactions,
- rarely anaphylactic reactions,
- swelling of the face
- dyspnoea,
- temperature increase,
- chills (rare), their relationship with the preparation has not been established,
- gastrointestinal complaints (e.g. abdominal pain, heartburn, nausea and constipation).
How to apply: dosage and course of treatment
Inside, during a meal, with a small amount of liquid. Adults and children over 12 years of age are prescribed – tablets of the drug: 30 mg 3 times a day for the first 2-3 days, then 30 mg 2 times or 15 mg 3 times a day, or 1 retard capsule (75 mg) in the morning; children 6-12 years old – 15 mg 2-3 times a day.
Oral solution (7.5 mg / ml) for adults during the first 2-3 days – 4 ml, and then 2 ml 3 times a day or 4 ml 2 times a day; children under 2 years – 1 ml 2 times a day, 2-5 years – 1 ml 3 times a day, 5-12 years – 2 ml 2-3 times a day.
Syrup of the drug (3 mg / ml) for adults – in the first 2-3 days, 10 ml, and then 5 ml 3 times a day or 10 ml 2 times a day. In severe cases of the disease, the dose is not reduced during the entire course of treatment. Children 5-12 years old are prescribed 15 mg 2-3 times a day, 2-5 years old – 7.5 mg 3 times a day, up to 2 years old – 7.5 mg 2 times a day.
In the form of inhalations, adults and children over 5 years old are prescribed 15-22.5 mg, children under 2 years old – 7.5 mg, children from 2-5 years old – 15 mg 1-2 times a day. In the case when it is not possible to carry out more than one inhalation per day, tablets, solution or syrup are additionally used orally.
Parenterally administered intramuscularly, intravenously (slowly, stream or drip) or s / c: adults – 15 mg, in severe cases – 30 mg 2-3 times a day; children – 1.2-1.6 mg / kg 3 times a day. Usually for children under 2 years old – 7.5 mg 2 times a day, from 2 to 5 years old – 7.5 mg 3 times a day, from 5 years old – 15 mg 2-3 times a day. For the treatment of respiratory distress syndrome in premature and newborn babies, 10 mg/kg/day is administered intravenously or intramuscularly, the frequency of administration is 3-4 times, if necessary, the dose can be increased to 30 mg/kg/day.
For intravenous drip, 50 ml is diluted in 500 ml of an infusion solution (0.9% NaCl solution, 5% dextrose solution, Ringer -Locke solution or other basic solution with a pH not higher than 6.3 is used as a solvent), injected within 2 hours at a rate of 84 drops / min. Repeated treatment according to the above scheme can be carried out after 14 days (while maintaining the indications).
Parenteral administration is stopped after the disappearance of acute manifestations of the disease (switch to oral or rectal administration).
Rectally, adults and children over 12 years old – 1 suppository (30 mg) 3 times a day for 2-3 days, then 60 mg 2 times a day, the maximum daily dose is 0.12 g; children 6-12 years old – 15 mg 2-3 times a day.
It is not recommended to use without medical prescription for more than 4-5 days.
Pharmachologic effect
Mucolytic agent, stimulates prenatal development of the lungs (increases the synthesis, secretion of surfactant and blocks its decay). It has a secretomotor, secretolytic and expectorant effect; stimulates the serous cells of the glands of the bronchial mucosa, increases the content of the mucous secretion and the release of a surfactant (surfactant) in the alveoli and bronchi; normalizes the disturbed ratio of serous and mucous components of sputum. By activating hydrolyzing enzymes and increasing the release of lysosomes from Clark cells, it reduces the viscosity of sputum. Increases the motor activity of the ciliated epithelium, increases mucociliary transport.
After oral administration, the action occurs after 30 minutes, with rectal administration – after 10-30 minutes and lasts for 6-12 hours. With parenteral administration, the action occurs quickly and lasts for 6-10 hours.
Special instructions
It should not be combined with antitussive drugs that make it difficult to remove sputum.
The inhalation solution of the drug can be used using any modern equipment for inhalation (except for steam inhalers). Before inhalation, the drug is mixed with a 0.9% NaCl solution (for optimal air humidification, it can be diluted in a ratio of 1: 1) and heated to body temperature. Inhalations should be carried out in normal breathing mode (so as not to provoke coughing shocks).
Patients suffering from bronchial asthma, in order to avoid non-specific irritation of the respiratory tract and their spasm, should use bronchodilators before inhalation with the drug.
Patients suffering from diabetes can be administered as a syrup (5 ml of syrup contains sorbitol and saccharin in an amount corresponding to 0.18 XE).
Children under 5 years of age are not recommended to use 15 mg suppositories, up to 12 years – 30 mg (15 mg suppositories are used for them).
Interaction
Combined use with antitussive drugs leads to difficulty in sputum discharge against the background of a decrease in cough.
Increases penetration into the bronchial secretion of amoxicillin , cefuroxime , erythromycin and doxycycline .
Solution for injection should not be used with solutions with a pH higher than 6.3.
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