Modafen for respiratory infections. Composition and dosage of the drug

Modafen is a drug used in family medicine for the symptomatic treatment of respiratory infections. The preparation has an effect on the musculoskeletal system, having an analgesic, antipyretic and anti-inflammatory effect. Modafen is available over the counter.

Modafen (Zentiva)

Indications for use of the drug Modafen

Modafen is administered to patients in the course of acute viral infections (flu, colds): headache, joint and muscle pain, fever, nasal obstruction. The active substances are ibuprofen and pseudoephedrine.

Dosage: adults and children over 12 years of age should take Modafen orally. Initially two tablets, then 1-2 tablets if necessary. every 4-6 hours. Maximum dose: six tablets a day.

Modafen, contraindications and warnings

Contraindications to the use of Modafen are:

1. hypersensitivity to any of the ingredients or other non-steroidal anti-inflammatory drugs,
2. active gastric and / or duodenal ulcer disease, or in the history of
3. gastrointestinal perforation or bleeding, including non-steroidal anti-inflammatory drugs
4. severe cardiovascular disease (e.g. ischemic heart disease, severe heart failure, severe hypertension, tachycardia),
5. overactive thyroid gland
6. hemorrhagic diathesis,
7. angle-closure glaucoma,
8. urinary retention,
9. A history of haemorrhagic stroke or the presence of risk factors that may increase the likelihood of a hemorrhagic stroke (e.g. taking vasoconstrictor drugs or other oral or nasal decongestants)
10. simultaneous use of other non-steroidal anti-inflammatory drugs, including COX-2 inhibitors,
11. severe liver or kidney failure, pregnancy, breastfeeding,
12. Do not use in patients who have ever experienced hypersensitivity symptoms such as rhinitis, urticaria or asthma after taking acetylsalicylic acid or other non-steroidal anti-inflammatory drugs.

Modafen – warnings

1. Do not use in children under 12 years of age.
2. If symptoms worsen or do not improve within 3 days, a doctor should be consulted.
3. Particular caution should be exercised in people with hypertension and / or cardiac dysfunction, a history of myocardial infarction or heart failure, with hepatic dysfunction, renal dysfunction, blood coagulation disorders (ibuprofen may prolong bleeding time), symptoms of neurological disorders (nausea, headache), with obstruction of the bladder neck, with pyloric stenosis, with benign prostatic hyperplasia, in diabetic patients.
4. Patients with systemic lupus erythematosus and mixed connective tissue disease are at increased risk of developing aseptic meningitis.
5. Patients with a history of gastrointestinal disease such as ulcerative colitis, Crohn’s disease and Crohn’s disease may worsen them.
6. In people with bronchial asthma (active or past asthma) and allergic diseases, the intake of the preparation may cause bronchospasm.
7. The elderly are at increased risk of side effects. To reduce the risk of side effects, it is recommended to take the preparation in the lowest effective dose for the shortest possible period.
8. There is a risk of gastrointestinal haemorrhage, ulceration or perforation which may be fatal and may not necessarily be followed by warning symptoms.
9. Tell your doctor about any unusual gastrointestinal symptoms (especially bleeding), especially at the beginning of treatment. This applies especially to the elderly and people with gastrointestinal diseases, for whom it is recommended to use the lowest dose possible.
10. The use of anticoagulants (e.g. warfarin, acenocoumarol), anti-aggregating drugs (e.g. acetylsalicylic acid), corticosteroids increases the risk of bleeding and gastrointestinal dysfunction.
11. Severe skin reactions, some of them fatal (exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis), may occur.
12. The greatest risk of the above-mentioned reactions occurs at the beginning of treatment.
13. At the first appearance of skin symptoms (e.g. rash, damage to the oral mucosa, other signs of hypersensitivity), the treatment should be discontinued and a doctor should be consulted.
14. Long-term use of the preparation in high doses may increase the risk of a heart attack or stroke.
15. Long-term parallel use of ibuprofen and other pain medications may cause renal failure. There is evidence that NSAIDs can cause temporary impairment of female fertility.
16. You should not drink alcohol during treatment.
17. The pseudoephedrine contained in the preparation is a substance not allowed for athletes (it may cause a positive result in tests for taking doping substances); there is a risk of drug abuse and its toxic effects.
18. Long-term use may lead to the development of tolerance and increase the risk of overdose. Depression may occur when you stop using it suddenly.
19. The preparation contains lactose; patients with hereditary disorders of galactose intolerance, the lactase deficiency or malabsorption of glucose-galactose should not use the preparation.
20. Use during pregnancy and breastfeeding is contraindicated.
21. Particular caution should be exercised when driving a motor vehicle.

Modafen with other drugs

Due to the content of pseudoephedrine, do not use simultaneously with MAO inhibitors and for 14 days after the end of treatment with MAO inhibitors (a life-threatening hypertensive crisis may occur). Pseudoephedrine has a decongestant effect on the blood vessels of the nasal mucosa and due to the increased risk of hypertension, it is not recommended to be used with the following drugs: dopamine receptor stimulants, ergot derivatives (bromocriptine, cabergoline, lisuride, pergolide), vasoconstrictor drugs ( dihydroergotamine, ergotamine, methylergometrine), linezolid, sympathomimetic drugs (decongestants of the blood vessels of the mucous membranes) such as phenylephrine, ephedrine, phenylpropanolamine, tricyclic antidepressants, appetite suppressants and psychotropic drugs similar to the methylnadciferine , hellebore alkaloids, guanethidine (pseudoephedrine may reduce the antihypertensive effect of these drugs). Pseudoephedrine in combination with anesthetic drugs in general can cause an acute hypertensive reaction. The use of the preparation should be discontinued at least 24 hours before the planned general anesthesia. Antacids increase the rate of pseudoephedrine absorption and kaolin reduces it. Parallel use of potassium-sparing diuretics may lead to hyperkalemia. Due to the ibuprofen content, the preparation should not be used with the following drugs: acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (because the risk of side effects increases); diuretics or antihypertensives (possible reduction in their effectiveness); anticoagulants (possible increase in their effect, e.g. warfarin); zidovudine (risk of prolonged bleeding time); methotrexate and lithium (possible increase in plasma levels of both lithium and methotrexate; it is recommended to control their concentration in the blood); corticosteroids (increased risk of side effects, especially in the gastrointestinal tract); cardiac glycosides, e.g. digoxin (risk of increasing heart failure and increasing plasma concentration of cardiac glycosides); cyclosporin (increased risk of nephrotoxicity); quinolone antibiotics (increased risk of convulsions). Ibuprofen increases the plasma concentration of phenytoin and increases the toxicity of baclofen. Ibuprofen reduces the urinary excretion of uric acid under the influence of probenecid and sulfinpyrazone.

Modafen – side effects

The following may occur: indigestion, abdominal pain and discomfort, heartburn, nausea, diarrhea, flatulence, constipation, vomiting, gastritis, gastrointestinal bleeding and perforation (may be fatal, especially in the elderly), tarry stools, bloody vomiting, peptic ulcer disease, decreased urine output, renal failure, renal papillary necrosis, increase in plasma sodium (sodium retention), difficulty urinating, edema, hypertension , heart failure, palpitations, tachycardia, drowsiness, headache and dizziness, agitation, irritability, insomnia, fatigue, psychotic reactions, tinnitus, blurred vision, tremors, muscle weakness, anxiety. Very rarely, disorders of the blood and the lymphatic system may occur, such as: haemolytic and aplastic anemia, agranulocytosis, leukopenia, thrombocytopenia, pancytopenia (the first symptoms of these disorders include: fever, sore throat, superficial ulceration of the oral mucosa, flu-like symptoms, fatigue, bleeding) , bruises, ecchymosis, purpura, epistaxis). Hypersensitivity and allergic reactions (rash, pruritus, urticaria, erythema multiforme, swelling of the face, larynx, tongue, dyspnoea, decreased blood pressure, shock, acute shock, exacerbation of asthma, bronchospasm, toxic epidermal necrolysis, Stevens syndrome) may occur. and Johnson). Isolated cases of symptoms associated with aseptic meningitis (neck stiffness, headache, nausea, vomiting, fever, confusion) have been reported in people with autoimmune diseases (e.g. lupus erythematosus). Long-term use of ibuprofen in high doses (2400 mg daily) may increase the risk of heart attack or stroke.