Mesopral – composition, action, indications. How to use Mesopral?

Proven content

Mesopral is a medicine that reduces the production of acid in your stomach. A prescription, it is available in the form of hard gastro-resistant capsules. It is intended for use by adults.

Mesopral – action

Mesopral is a drug whose action is related to the presence of esomeprazole – the active substance, which is an optical isomer of omepresol. The active ingredient helps to block the proton pump in the parietal cells of the gastric mucosa, which results in the inhibition of hydrochloric acid secretion.

Mesopral – composition

1 capsule of Mesopral contains 20 mg or 40 mg of esomeprazole in the form of ezoineprazole magnesium dihydrate, respectively.

The other ingredients in the composition of Mesopral:

1. in the capsule: sucrose, grains (sucrose and maize starch), hypromellose 3 cP, dimethicone 35% emulsion (contains dimethicone, propyl parhydroxybenzoate (E216), methyl parahydroxybenzoate (E218), sorbic acid, sodium benzoate, polyethyleneglycolate, polyethylene glycolate octylphenoxy polyethoxyethanol, propylene glycol), polysorbate 80, mannitol, diacetylated monoglycerides, talc, methacrylic acid and ethyl acrylate copolymer (1: 1), 30% dispersion (containing methacrylic acid and ethyl acrylate copolymer, sodium lauryl sulfate and polysorbate 80) citrate and macrogolglyceride stearates.
2. forming the gelatin shell of the capsules: black iron oxide (E72), shellac, gelatin, yellow iron oxide (E172) and titanium dioxide (E171).

Mesopral – indications

Mesopral is a drug intended for adults and adolescents over 12 years of age:

1. struggling with gastro-oesophageal reflux disease
2. to prevent the return of reflux oesophagitis
3. for symptomatic treatment of gastro-oesophageal reflux disease
4. in the eradication of Helicobacter pylori in combination therapy with antibiotics.

The capsules can also be used to treat the erosions associated with reflux oesophagitis.

Adults can also receive Mesopral for long-term treatment aimed at preventing recurrent bleeding from peptic ulcers and for the treatment of Zollinger-Ellison syndrome.

Mesopral – dosage

Use mesopral as instructed by your doctor.

Sample dosage for adults:

1. in the treatment of erosions – 40 mg once a day for 1 weeks
2. for the prevention of recurrence of reflux oesophagitis – 20 mg once a day
3. in the eradication of H. pylori in the treatment of peptic ulcer disease – 2 mg twice a day in combination with appropriately selected antibiotics for 2 days
4. for the treatment of Zollinger-Ellison syndrome – starting dose: 40 mg twice a day, maintenance dose 2-80 mg daily.

Sample dosage for adolescents after 12 years of age:

1. in the treatment of erosions in the course of reflux oesophagitis – 40 mg once daily for 1 weeks
2. for the prevention of relapse of reflux oesophagitis – 20 mg once a day
3. in the treatment of duodenal ulcer caused by H. pylori – 20 mg twice a day in combination with antibiotics for 2-7 days.

Mesopral – contraindications to use

Mesopral is a drug that must not be administered in the case of:

1. hypersensitivity to any component of the preparation,
2. taking nelfinavir-containing antiviral drugs.

The drug should not be administered to pregnant women and women during breastfeeding.

Mesopral – warnings

Warnings about Mesopral:

1. in some situations it is necessary to conduct check-ups;
2. before starting the treatment, the neoplastic nature of the disease should be ruled out;
3. in the case of long-term treatment (over 12 months), the patient must be under constant medical supervision;
4. in the case of combination therapy, there may be an interaction between esomeprazole and the antibiotics taken;
5. during the treatment, there is a risk of gastrointestinal infections caused by Campylobacter and Salmonella bacteria;
6. long-term treatment may reduce the absorption of vitamin B12;
7. in the case of therapy longer than 3 months, the patient should undergo control tests consisting in determining the level of magnesium in the body;
8. long-term treatment (over 12 months) may increase the risk of bone fractures – especially in the elderly or those at risk;
9. sometimes taking the drug may result in the occurrence of a subacute cutaneous form of lupus erythematosus.

Mesopral – drug interactions

Before starting therapy, inform your doctor about any medications you are currently taking – also over-the-counter medications.

1. Esomeprazole in combination with high doses of methotrexate may increase the concentration of methotrexate.
2. Concurrent administration of esomeprazole with tacrolimus may increase tacrolimus concentrations.
3. Mesopral may reduce or enhance the effect of drugs with a pH dependent absorption.
4. Mesopral should not be used concomitantly with nelfinavir (a medicine used to treat HIV infection).

Caution should be exercised when taking medications containing, inter alia, diazepam, cilostazol, voriconazole, citalopram.

Mesopral – side effects

Mesopral, like any other drug, may cause side effects.

Common side effects include: balance disorders, somnolence, paraesthesia, vomiting, diarrhea, dermatitis, pruritus.

Rarely or very rarely, they appear, among others hypersensitivity reactions, agitation, depression, aggression, hematological disorders, inflammation of the oral mucosa, yeast infection of the gastrointestinal tract.

Possible side effects for which their frequency has not been established, such as: hypomagnesaemia (decrease in blood magnesium), hypocalcaemia (decrease in blood calcium), hypokalaemia (decrease in blood potassium), microscopic colitis, subacute cutaneous lupus erythematosus.

Mesopral and alcohol

So far, no relevant data have been collected to suggest any interactions between Mesopral and alcohol. Nevertheless, be extremely careful and consult your doctor or pharmacist if you are unsure.

Mesopral and driving

Mesopral is unlikely to affect your ability to drive and use machines. However, side effects such as dizziness and blurred vision may occur. If this happens, you should not drive or operate machinery.