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Lipidogram – also known as the lipid profile – is a test performed to check whether the lipid (fat) balance in our body is functioning properly. The analysis of the four basic parameters that determine the lipid profile – CHOL, HDL, LDL and TG – and other data, such as the atherogenicity index, helps in assessing the risk of serious cardiovascular disease. How is the lipid profile performed and how to interpret its results?
The body’s lipid balance
The body – as a “connected vessel system” – cannot function properly if one of its components is defective. The lipid metabolism and its balance turns out to be extremely important for our overall health. Lipids are an efficient source of energy – a large demand for these substances occurs in people in adolescence, as well as in adults who lead an active lifestyle or work physically. However, it should be remembered that it gradually decreases with age.
Worth knowing
Lipids are responsible for maintaining the proper water and electrolyte balance in the body. They also build cell membranes and are solvents for water-insoluble substances necessary for the body to function.
When the lipid metabolism (for various reasons) is disturbed, the risk of serious circulatory diseases, such as ischemic heart disease (coronary artery disease) or atherosclerosis, increases. Elevated blood lipids are also often directly related to being overweight and obese.
Lipidogram – what is it?
A lipidogram is a test in which four basic parameters are determined:
- LDL cholesterol (LDL-C, low-density lipoprotein fraction) – the so-called “bad cholesterol”. When it exceeds the appropriate values, it accumulates in the walls of the blood vessels, which leads to the development of diseases of the cardiovascular system.
- HDL cholesterol (HDL-C, high-density lipoprotein fraction) – the so-called “good cholesterol”. It prevents the accumulation of cholesterol in the blood vessels and supports the work of the circulatory system.
- Total cholesterol (CHOL or TC). The total concentration of LDL and HDL cholesterol.
- Triglycerides (TG or TAG). Too high concentration of these lipids can lead to cardiovascular disease, as well as the development of acute pancreatitis.
Moreover, the lipidogram shows the mutual relations and dependencies they show blood lipids – are the values defined as index of atherogenicitysuch as, but not limited to:
- the plasma index API (Atherogenic Index of Plasma – interrelationships of LDL, IDL, VLDL and HDL levels);
- Castelli index (CHOL / HDL ratio)
- LDL / HDL ratio;
- ratio of apoliprotein B to apoliprotein AI (ApoB / ApoA-I)
- LDL-ApoB ratio.
The lipid profile is performed to determine the level of individual lipids and the relationship between them, and then – on this basis – to implement appropriate treatment or prophylactic measures. A lipidogram is a screening test used primarily in assessing the risk of developing diseases such as:
- atherosclerosis;
- coronary artery disease;
- myocardial infarction;
- stroke;
- adhesive atherosclerosis of the arteries of the lower extremities.
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The rest of the text is below the video.
Lipidogram – when to do the test?
Who should check their lipid profile? Cholesterol testing it is recommended for all women over 45 and men over 35. After the age of 50, it is recommended to repeat the test every two years, and if the results are elevated – every year. People taking medications to lower cholesterol should have their lipid profile checked even more often: preferably every six months.
On Medonet Market you will find test packages for women (Women’s health check – diagnostic blood tests) and for men (Prophylactic blood tests for men), in which the lipid profile is also determined.
However, it is worth taking care of your health much earlier. The first lipid profile can be performed around the age of 20, and subsequent ones – repeated every 5 years. Is it worth it? Absolutely: it is one of the basic diagnostic tests. If any abnormalities are detected early, appropriate treatment can be implemented faster and more effectively. As a result, the blood vessels will be less exposed to the adverse effects of high cholesterol.
Swoj profile lipidowyregardless of age, they should also constantly monitor:
- overweight and obese people;
- people leading a less active lifestyle;
- people suffering from diabetes, chronic kidney disease and chronic inflammatory diseases;
- patients suffering from arterial hypertension;
- heavy smokers;
- people with a genetic predisposition to hypercholesterolaemia and cardiovascular diseases (when cases of these diseases had previously appeared in family members).
Lipidogram – preparation for the examination
The lipidogram is determined on the basis of a venous blood sample, which is most often collected from a vein in the elbow flexion. The test is always performed in the morning, usually between 7:00 and 10:00. The patient should present for the examination on an empty stomach – preferably, it should be about 13-14 hours from the last meal to the collection of the blood sample. Before the examination itself, you should rest in a sitting position for several minutes.
IMPORTANT
For a reliable lipid profile, you should not change your usual, regular diet in the days before sample collection for analysis. Both fasting and overeating (e.g. at a family event) may distort the test – the lipid profile will then have to be repeated.
For a few days before examining the lipidogram (minimum 2-3), you should also give up alcohol completely. On the eve of the examination, it is recommended to avoid strenuous exercise and stressful situations.
Check what a cholesterol lowering diet should look like
Lipidogram – norms
What values should the lipid profile take? Standards for a healthy person, regardless of gender, are as follows:
- total cholesterol (TC): 150-190 mg / dL;
- LDL cholesterol (LDL-C): less than 115 mg / dL,
- triglycerides (TG): 35-150 mg / dL.
As for HDL cholesterol fraction values (HDL-C, “good cholesterol”), the correct values - determined not by the upper limit but by the lower limit – are different for men and women:
- in women – over 50 mg / dl
- in men – over 40 mg / dl.
By analyzing index of atherogenicity, Castelli’s index should normally take the following values:
- in healthy women – less than 4,0;
- in women after a myocardial infarction – less than 3,0;
- in healthy men – less than 4,5;
- in men after a myocardial infarction – less than 3,5.
WARNING
One should not draw far-reaching conclusions from the individual values that the lipidogram analysis has brought. Interpretation of the results must be made by a competent physician who will compare it with the patient’s individual circumstances and the results of his other tests. Moreover, the norms of the lipid profile differ significantly for patients suffering from diseases such as diabetes or coronary artery disease – in such a situation they should not be compared with the tables of values for healthy people.
Lipidogram – interpretation of results
Lipid profile and its results help in the diagnosis of numerous diseases and allow for appropriate treatment or further diagnostic tests. What can they testify to abnormal results of the lipid profile?
If the lipidogram shows elevated levels of total cholesterol and LDL cholesterol, this may indicate:
- inappropriate lifestyle – too low level of physical activity, poor diet with lots of animal fats and simple carbohydrates;
- Hypothyroidism;
- liver disease;
- chronic kidney disease and other renal conditions;
- genetic predisposition to elevated cholesterol.
The high value of this index may also result from other factors, such as the use of hormonal contraception or therapy with the use of glucocorticosteroids.
In the case of total cholesterol and “bad” LDL cholesterol low scores are most welcome. However, it may happen that their values are too low, which is usually related to:
- malnutrition;
- wasting of the body as a result of other diseases and related treatment;
- cirrhosis of the liver;
- overactive thyroid gland.
IMPORTANT
Too low concentration of “good” cholesterol (HDL) is usually associated with an inappropriate lifestyle and a diet poor in products that are the source of this substance. It is worth taking care of increasing HDL concentration in order to be within the proper norm for us – otherwise there may be problems with the proper functioning of the circulatory system.
Determine your lipid profile before visiting a dietitian to establish an appropriate diet. Buy a package of tests now before consulting a dietitian – home blood analysis, in which you can also determine the level of TSH, vitamin D, iron or cortisol.
At elevated levels of triglycerides the problem may be:
- improper diet and lack of physical activity;
- inflammation of the pancreas;
- kidney failure;
- Hypothyroidism;
- diabetes;
- obesity;
- insulin resistance;
- genetic predisposition to elevated triglyceride levels.
WARNING
Interpretation of the results by a doctor examining our lipid profile should depend on our overall health and lifestyle. In some cases, the reliability of the obtained results may be questionable. Apart from the aforementioned factors that may distort the result (alcohol, diet changes, exertion before the test), one of such cases is vitamin C overdose. It may lower the lipid profile values.
Lipidogram – price
The lipidogram is not an expensive test. In its standard version, when the test includes the determination of total cholesterol, HDL, LDL and triglycerides, it usually costs from 5 to 10 Euro. The test can also be performed at the National Health Fund with a referral from a doctor – then it is free. The lipidogram is also often included basic diagnostic test packages performed by laboratories. At Medonet Market you can buy, for example, a preventive examination package – blood tests with a lipid profile as one of the tests.
Lipidogram – FAQs
What is research used for?
- To assess the risk of developing cardiovascular disease.
- For dynamic monitoring of patients with coronary heart disease, hypertension, atherosclerosis of the heart and blood vessels, kidney pathology, diabetes mellitus.
- To evaluate patients with a family history of hypercholesterolemia and a high risk of myocardial infarction or stroke.
- To control lipid-lowering therapy and diet.
When is the study scheduled?
- During a preventive examination of healthy people (after 20 years, it is recommended to determine the level of lipids in the blood every 5 years).
- With an increase in total cholesterol.
- With a history of high cholesterol.
- With a burdened hereditary history (diabetes mellitus, stroke, myocardial infarction, arterial hypertension).
- If there are factors that increase the risk of cardiovascular complications (age over 45 years for men and 55 years for women, smoking, overweight, carbohydrate metabolism disorders, high blood pressure).
- When monitoring the effectiveness of a lipid-lowering diet and / or drug treatment with statins.
What do the results mean?
Reference values
Atherogenic coefficient: 2.2 – 3.5.
Triglycerides: < 1.7 mmol/L.
Cholesterol – high density lipoproteins (HDL): men > 1.0 mmol / l; women: > 1.2 mmol/l.
Cholesterol – low density lipoprotein (LDL): < 3.0 mmol / l.
Cholesterol – very low density lipoprotein (VLDL): < 0.8 mmol / l.
Cholesterol – non-HDL: < 3.4 mmol/L.
Total cholesterol: < 5.2 mmol/L.
The risk of development and progression of atherosclerosis and cardiovascular diseases increases with:
- elevated levels of total cholesterol, LDL, VLDL, triglycerides;
- low HDL;
- increased coefficient of atherogenicity – more than 3.
Assessment of the risk of cardiovascular complications is carried out according to the SCORE system, taking into account age, gender, smoking and systolic blood pressure.
In accordance with international recommendations for assessing lipid levels 1 , lipidogram indicators are interpreted as follows.
“Diagnosis and correction of lipid metabolism disorders for the prevention and treatment of atherosclerosis. Russian recommendations, VII revision. 2020”.
“2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk”.
total cholesterol
A level < 5.2 mmol/L is optimal. For an individual risk assessment, the result must be used in combination with other indicators (SCORE scale).
LDL cholesterol
A level < 3.0 mmol/L is optimal for patients with low cardiac risk. Target LDL levels for high and very high risk patients are determined by the physician.
HDL cholesterol
Levels > 1.0 mmol/L for men and > 1.2 mmol/L for women indicate low cardiac risk.
Cholesterol – non-HDL (cholesterol not associated with high density lipoproteins).
A level < 3.4 mmol/L is desirable for individuals at moderate cardiovascular risk. Non-HDL targets for high and very high risk patients are determined by the physician.
Triglycerides
Level
What can influence the result?
- Factors that can distort the result:
- physical activity, stress, acute infection, trauma;
- consumption of food and alcohol shortly before the study;
- smoking before testing;
- prolonged fasting, anorexia;
- a study with intravenous administration of a radiopaque substance shortly before the study;
- concomitant diseases without adequate treatment (pathology of the liver, kidneys, endocrine disorders);
- pregnancy.
- Drugs that increase the level of total cholesterol: beta-blockers, corticosteroids, lansoprazole, lithium salts, oral contraceptives, phenobarbital, thiazides.
- Total cholesterol lowering drugs : estrogens, allopurinol, androgens, statins, fibrates, fatty acid sequestrants, levothyroxine, filgrastim, tamoxifen.
- Medicines that increase HDL levels: steroids, progestins, androgens, alpha-blockers, carbamazepine, lipid-lowering drugs, estrogens, hydroxychloroquine, indapamide, insulin, hypoglycemic drugs, phenobarbital, phenytoin.
- HDL -lowering drugs : oral contraceptives, beta-blockers, methimazole, methyldopa, tamoxifen, thiazides.
- Drugs that increase LDL levels : anabolic steroids, aspirin, carbamazepine, corticosteroids, oral contraceptives, phenothiazides, progestins, sulfonamides.
- LDL- lowering drugs : cholestyramine, clofibrate, estrogens, neomycin sulfate, nicotinic acid, statins, thyroxine.
- Drugs that increase the level of triglycerides : beta-blockers, cholestyramine, corticosteroids, estrogens, oral contraceptives, thiazide diuretics.
- Drugs that reduce the level of triglycerides : ascorbic acid, asparaginase, colestipol, clofibrate, metformin, niacin.
Important Notes
- With an excess of total cholesterol in the blood due to LDL, which is also expressed in an increase in the atherogenic coefficient, a diet and lipid-lowering therapy are prescribed, the purpose of which is to achieve an optimal level of lipids in the blood. The target lipid level depends on risk factors and comorbidity.
- The study of the lipid profile of the blood should not be carried out immediately after myocardial infarction and for another three months after it.
- The results of the analysis are taken into account in combination with other risk factors for the development of atherosclerosis and cardiovascular complications.
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