Lipancrea 8000, -16 – indications, dosage, contraindications, side effects

Lipancrea 8000, -16 is a preparation used in chronic pancreatitis, conditions after resection of the pancreas or its part, conditions after gastric resection, stenosis of the bile ducts caused by cancer, and cystic fibrosis. The preparation contains lipase, which hydrolyzes fats, and amylase, which breaks down proteins by decomposing starch and protease. The drug is in the form of capsules and is available without a prescription.

Lipancrea 8000, -16 000 (Polfa Warsaw)

ACTION

Lipancrea 8000, -16 contains pancreatic enzymes of animal origin.

Lipancrea 8000, -16 – indications and dosage

Lipancrea 8000 is indicated for:

1. chronic pancreatitis,
2. conditions after resection of the pancreas or its part,
3. conditions after gastrectomy,
4. narrowing of the bile ducts caused by cancer,
5. cystic fibrosis.

Drug dosage

Lipancrea 8000, -16 is in the form of capsules and is intended for oral use. The drug should be taken with a meal, washed down entirely with liquid. Do not crush the capsules as this may damage the pellets and make the medicine inactive. You can open the capsule and take its contents with a small amount of e.g. fruit juice. The dosage of the drug is individual and depends on the clinical response.

1. Do not use more than 100 U.
2. Kids. 500-1000 units Ph. Eur. lipases / kg bw / meal (e.g. children weighing 15 kg – 1-2 capsules at a dose of 8000 per meal). Do not use a dose higher than 2500 U. Ph. Eur. lipase / kg bw / meal or 10 units Ph. Eur. lipase / kg bw / dw. division

Lipancrea 8000, -16 and contraindications

There are the following contraindications for taking Lipancrea 8000, -16:

1. hypersensitivity to pancreatin,
2. pork allergy,
3. acute pancreatitis.

Lipancrea 8000, -16 – warnings

1. Consult your doctor before using the drug if you are taking preparations of the H2 receptor antagonist group (e.g. cimetidine, ranitidine, famotidine). They can make the drug less effective.
2. Administering the drug to children is only possible after medical consultation.
3. Occasional cases of bowel stricture have been reported during treatment with the drug in children with cystic fibrosis. The cause is unknown, but it is associated with overdosing.
4. Do not use a dose higher than 2 500 units of lipazine kg body weight in children. per meal (10 units of Ph. Eur lipase per kg of body weight per day in divided doses).
5. Consult your doctor if you persist and experience severe abdominal pain while taking this medicine.
6. Pregnant and breastfeeding women may use the drug only after consulting a doctor and only when the benefit of the mother outweighs the possible risk to the child.

Lipancrea 8000, -16 with other drugs

1. Drugs that reduce gastric acidity, such as cimetidine, ranitidine, and famotidine, may reduce the effectiveness of the drug.
2. The use of the drug may reduce the absorption of folic acid from the gastrointestinal tract and reduce the absorption of iron salts. In this situation, it may be necessary to supplement the deficiencies of these compounds.
3. Taking the drug with foods with a pH higher than 5,5, e.g. eggs, chickens, veal, green peas, may reduce its effectiveness, leading to inactivation of enzymes in the stomach’s lumen, as well as irritation of the oral mucosa.

Lipancrea 8000, -16 – side effects

While taking Lipancrea 8000, -16 the following may occur:

1. abdominal pain,
2. constipation
3. abnormal stools
4. diarrhea,
5. nausea,
6. vomiting,
7. allergic reactions
8. skin hypersensitivity,
9. itching of the skin (not requiring drug discontinuation),
10. irritation of the oral mucosa or the perianal area.

with high doses of Lipancrea 8000, -16 the following may occur:

1. increase in uric acid levels in the urine
2. diarrhea,
3. rarely, changes in the intestine consisting of its narrowing (fibrosing colonopathy) in a small number of patients with cystic fibrosis receiving high doses of pancreatin.