Used in the prevention and treatment of seasonal and perennial allergic rhinitis, the treatment of chronic idiopathic urticaria, and the prevention and treatment of allergic conjunctivitis.
Letizen (Krka)
| form, dose, packaging | availability category | the active substance |
| tabl. 0,01 g (7 tabl.) | OTC (over-the-counter) | cetirizine (cetirizine dihydrochloride) (cetirizine dihydrochloride) |
ACTION
H1 receptor antagonist
INDICATIONS AND DOSAGE
Prevention and treatment of allergic, seasonal and perennial rhinitis. Treatment of chronic idiopathic urticaria. Prevention and treatment of allergic conjunctivitis. Orally. Adults and children after 12 years of age 10 mg once daily. Children 1-6 years old years of age (> 12 kg bw). 30 mg (5/1 tablet) 2 × / day Children 2-6 years old years of age (<12 kg bw). 30 mg (5/1 tablet) 2 × / day In people with moderate renal impairment, in people undergoing hemodialysis and in people with liver failure 1 mg (5/1 tablet) / day.
CONTRAINDICATIONS
Hypersensitivity to any component of the preparation or to hydroxyzine.
WARNINGS
Do not use in children under 6 years of age. Caution should be exercised in patients with renal insufficiency, undergoing hemodialysis, and in patients with hepatic impairment; it is recommended to use lower daily doses. Treatment should be discontinued at least 3 days before scheduled allergy skin testing. During treatment, alcohol consumption and the use of drugs that depress the central nervous system should be avoided. The preparation contains lactose; people with hereditary disorders related to galactose intolerance, lactase deficiency or malabsorption of glucose-galactose should not use the preparation. It is not recommended for use in pregnant women (especially in the first trimester of pregnancy) due to the lack of data on the safety of its use; use of the preparation during pregnancy (in the second and third trimesters) only with the consent of the doctor and only if absolutely necessary. The preparation should not be used during breastfeeding. The preparation may cause drowsiness. People who drive motor vehicles should exercise caution and check how they react to cetirizine, as in rare cases the drug may cause adverse reactions (e.g. blurred vision) that may impair the ability to concentrate and react.
INTERACTIONS
Theophylline (an asthma drug) at doses of 400 mg daily may reduce the rate of cetirizine excretion. Cetirizine in combination with alcohol or drugs that depress the central nervous system may increase their depressant effects on the central nervous system (sedative, hypnotic). The preparation may affect the results of allergic skin tests.
SIDE EFFECTS
Headache, dizziness, drowsiness, fatigue, sedation, dry mouth, throat irritation, cough, pharyngitis, nausea, diarrhea, abdominal pain, thrombocytopenia, difficulty urinating, eye accommodation disorders, blurred vision, tachycardia ( increased heart rate), edema, liver dysfunction (increased liver transaminases), cramps, paraesthesia, syncope, confusion, insomnia, agitation, hostility, skin reactions (rash, hives, itching) and angioedema (which may cause difficulty in breathing), shock anaphylactic.