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Lecalpin is a drug designed to block calcium channels. As a result, it acts on blood vessels and reduces the tension of smooth muscles in the vessel walls and has a dilating effect on them. Thus, it reduces peripheral vascular resistance, which lowers blood pressure.
How does Lecalpin work?
The main active ingredient in Lecalpinie jest lerkanidypinawhich, as a dihydropyridine derivative, is one of the calcium channel blockers. This substance is responsible for blocking the flow of calcium ions through the cell membrane, which reduces smooth muscle tone and dilates arterial vessels. Vasodilatation lowers blood pressure because peripheral vascular resistance is lowered, so that the heart is relieved and uses less energy and requires less oxygen. But at the same time lerkanidypina it does not affect the strength of contraction of the heart muscle, as it only affects the blood vessels.
Because Lecalpin is a drug with prolonged action, it is enough one tablet dailythat the blood pressure is lowered in people suffering from hypertension for the next 24 hours. The maximum concentration of the drug is reached 1,5–3 hours after dosing. An indication the use is therefore to lower blood pressure in people suffering from hypertension. The manufacturer of the drug Lecalpin is Actavis Polska.
Contraindications to the use of Lecalpin
Like any drug and Lecalpin shows some contraindications for use. First of all, allergy to the active substance or to other dihydropyridine derivatives is an absolute contraindication to using Lecalpin. It cannot be administered to people with restricted outflow tracts from the left ventricle, untreated congestive heart failure, unstable angina, during a heart attack and up to one month after a heart attack. Other contraindications do using Lecalpin are severe liver or kidney problems, use of drugs that reduce the activity of the cytochrome P3 4A450 isoenzyme (e.g. rifampicin or St. John’s wort), use of cyclosporine.
The drug is also not given to women Pregnant, during breastfeeding or during the childbearing periodwhen they are not using effective contraception. While taking the drug Lecalpin you must also not eat grapefruit juice. Alcohol should also be avoided as it may increase the effects of antihypertensive drugs. Lecalpin people with galactose intolerance, lactase deficiency or malabsorption of glucose-galactose can not be consumed, because the preparation contains lactose.
Lecalpin – dosage
Lecalpin are orally coated tablets. They should be taken at the same time each day, approximately 15 minutes before a meal. The doctor determines dose individually. Generally given to adults daily dose 10 mg as one tablet once a day. Only a doctor can increase dose if necessary, up to 20 mg daily. It cannot be changed by itself dose or take a double dosebecause it can harm your health and even life.
Lecalpin – possible side effects
Adverse reactionthat may occur while taking the drug Lecalpin These include headaches and dizziness, hot flushes, palpitations, peripheral edema and increased heart rate. Drowsiness, muscle pain, gastrointestinal problems or hypotension may very rarely occur. In the event of any symptoms undesirable the attending physician should be consulted immediately.
Before use, read the leaflet, which contains indications, contraindications, data on side effects and dosage as well as information on the use of the medicinal product, or consult your doctor or pharmacist, as each drug used improperly is a threat to your life or health.