Used in pain of mild or moderate intensity: headaches, including migraines, bone, joint and muscle pains, neuralgia and pains after surgical and dental procedures, and in fever.
Kofepar (Pliva Krakow)
| form, dose, packaging | availability category | the active substance |
| tabl. (10 tabl.) | OTC (over-the-counter) | kofeina, paracetamol (caffeine, paracetamol) |
SUBSTANCE 1 tablet contains: 0,5 g of paracetamol, 0,065 g of caffeine
ACTION
Combined preparation with analgesic and antipyretic properties
INDICATIONS AND DOSAGE
Pain of mild or moderate intensity: headache, including migraine, bone, joint and muscle pain, neuralgia and pain after surgical and dental procedures. Feverish states. Orally. Adults and children over 12 years of age. Ad hoc 1–2 tablets 3–4 × / d. In chronic pain 1 tablet. every 4-6 h. Dose max. 8 tablets / day.
CONTRAINDICATIONS
Hypersensitivity to any component of the preparation, severe liver or kidney failure, alcoholism, coronary artery disease, hypertension, cardiac arrhythmias, anxiety syndrome, glucose-6-phosphate dehydrogenase deficiency, XNUMXst trimester of pregnancy, breastfeeding.
WARNINGS
Do not use in children under 12 years of age. Do not use for more than 10 days for the treatment of pain and no more than 3 days for the treatment of fever without a doctor’s recommendation. In order to avoid overdose, check that other taken preparations do not contain paracetamol. Do not exceed the recommended doses. Caution should be exercised when using the drug in patients with impaired liver or kidney function or in patients with peptic ulcer disease. Do not drink alcohol during the treatment period due to the risk of toxic liver damage. The risk of liver damage is particularly high in fasting people (e.g. following restrictive diets) and regularly consuming alcohol. Use in women in the second and third trimesters of pregnancy only after consulting a doctor and only if absolutely necessary; the use in the first trimester of pregnancy and during breastfeeding is contraindicated. In therapeutic doses, the drug does not usually impair the ability to drive motor vehicles. However, people driving motor vehicles should be especially careful as it may cause side effects that may impair psychophysical fitness (arrhythmias, anxiety, muscle tremors).
INTERACTIONS
Paracetamol enhances the effect of coumarin derivative anticoagulants. Salicylamide increases the elimination time of paracetamol. Do not use with MAO inhibitors or within 14 days from the end of treatment with these preparations due to the possibility of agitation and high fever. The use of drugs that increase hepatic metabolism, such as rifampicin, antiepileptic drugs (phenobarbital, phenytoin, carbamazepine), some sleeping pills or alcohol consumption may cause toxic liver damage, even when using the recommended doses of paracetamol. The use of paracetamol and non-steroidal anti-inflammatory drugs increases the risk of renal dysfunction. Metoclopramide or domperidone accelerate, and cholestyramine delays the absorption of paracetamol from the gastrointestinal tract; caffeine enhances its analgesic effect. Paracetamol increases the toxic effects of zidovudine and chloramphenicol. The use of paracetamol may affect the results of laboratory tests (e.g. blood glucose determination). Caffeine has an effect opposite to that of hypnotics and antiepileptic drugs, and reduces the therapeutic effect of lithium. Oral contraceptives and cimetidine slow down the metabolism of caffeine, while barbiturates and smoking accelerate it. Excessive consumption of coffee or tea during the treatment period can make you feel tense and irritable. Please inform your doctor about all the recently taken drugs.
SIDE EFFECTS
Due to the presence of paracetamol in the preparation, the following may occur: nausea, vomiting, diarrhea, abdominal pain, headache, impaired liver and / or kidney function, pancreatitis, pruritus, urticaria, rash, erythema. Very rare: thrombocytopenia, agranulocytosis, methaemoglobinaemia. Due to the presence of caffeine, the following may occur: arrhythmias, headaches, sleep disturbances, muscle tremors.