Jeanine for endometriosis

Endometriosis is a disease of the female reproductive system, which is characterized by the proliferation of hormone-dependent endometrial cells in atypical places: in the abdominal cavity, pelvis and other parts of the body. For the treatment of endometriosis, hormonal agents are often used, one of which is Jeanine. These tablets are the drug of choice in their pharmacological group, due to their high efficiency. It has been proven that getting rid of endometriosis occurs with well-chosen therapy using Jeanine in 87-90% of cases.

Jeanine belongs to the combined oral contraceptives (COCs).

It contains in its composition two active substances of the estrogen and progestin series:

• Dienogest – 2 mg.

• Ethinylestradiol – 0,03 mg.

Mechanism of action of the drug

The effectiveness of the treatment of endometriosis with Jeanine is determined by its chemical composition. Dienogest has gestagenic-antiandrogenic activity, and ethinylestradiol inhibits the production of gonadotropic hormones by the pituitary gland.

Therapeutic effects are due to the following actions of active substances on the female body:

• The processes of ovulation in the ovaries are inhibited, the production of estrogen in the female body is reduced.

• The concentration of androgens in the blood of a woman decreases.

• The growth and development of endometrioid cells is inhibited.

• Foci of endometriosis decrease in size, and then completely atrophy.

• Enzymes responsible for the synthesis of prostaglandins OG E2 (the main mediators of pain and inflammatory reactions) enter the “block”. As a result, the woman ceases to be haunted by painful sensations.

• The active ingredients that make up Jeanine stimulate the breakdown of estrogens, making them inactive.

• The immune defense of the body is activated, which contributes to the destruction of endometriosis foci.

• In the tissues, new blood vessels cease to form, which would feed the pathogenic foci of endometriosis.

• The number of growth factors that are able to stimulate the proliferation of endometrial cells in atypical localizations is reduced.

• The peristalsis of the fallopian tubes is suppressed, which prevents the egg from moving through them. A larger amount of mucus accumulates in the cervix, which impairs the permeability of spermatozoa through it.

• The structure of the endometrium in the uterus changes, which makes it impossible for the embryo to attach to it.

The last two points relate to the contraceptive properties of the drug.

How to take Jeanine for the treatment of endometriosis?

Treatment of endometriosis with Jeanine is possible at various stages of the development of the disease. Gynecologists select a therapeutic regimen on an individual basis, depending on the state of health of the woman.

Jeanine can be prescribed to patients with endometriosis in the early stages, which often allows you to get rid of the disease without surgical intervention. If a woman is shown an operation, then the drug is prescribed to her to prepare the body for the upcoming intervention. In addition, Janine is discharged after undergoing surgery to remove endometriosis foci. This greatly reduces the risk of recurrence of the disease.

Possible treatment regimens:

• “21 days of admission and 7 days of rest.” This scheme is suitable for the treatment of endometriosis at an early stage. Such therapy is effective for a woman who plans to conceive a child in the near future. Every day she should drink 1 tablet of the drug, without gaps. Then you should take a break for 7 days, during which menstrual bleeding will open. The full course of treatment according to this scheme consists of 3 months.

• “42 days, 63 days, 84 days and 7 days off.” This scheme is called extended. Depending on the condition of the woman, the doctor recommends that she take Jeanine continuously for 6, 9 or 12 weeks, after which she needs to take a seven-day break. As a rule, such a scheme is suitable for the treatment of patients who have undergone surgery for the removal of endometriosis lesions. Also, a prolonged treatment regimen is recommended for those women in whom endometriosis is diagnosed in advanced form. A full course can last from six months to a year.

Start taking the drug from the first day of the menstrual cycle. If this was done later, the doctor recommends that the woman additionally use condoms during sexual intercourse, since Jeanine’s contraceptive activity will be reduced.

What tests should a woman take during treatment?

Treatment of endometriosis with hormonal drugs must necessarily take place under medical supervision. At least once every 1 days, a woman should visit a gynecologist for an examination.

At the same time, she should take the following tests:

• Blood for biochemistry.

• Blood for clinical analysis.

• Blood to determine the rate of its coagulation.

It is important to do an ultrasound of the pelvic organs once every 1 months.

Possible side effects of taking Jeanine

Like any other hormonal drug, Jeanine can provoke the development of the following side effects:

• Stroke, heart attack, thrombosis and thrombophlebitis of veins.

• Severe migraine headaches.

• Aggression, tearfulness, depression.

• The appearance of discharge by the type of thrush.

• Constant feeling of hunger, which can lead to weight gain.

• Visual impairment, inability to use contact lenses.

• Disorders from the work of the digestive organs.

• Allergic skin rashes.

• Pain in the region of the mammary glands.

• The appearance of bloody discharge from the vagina in the intermenstrual period.

It is worth noting that if a woman 100% follows the doctor’s recommendations, then the risk of side effects is minimized. In addition, most of the patients taking Jeanine note that side effects bother them only at the beginning of taking the drug. After the body adapts, they pass. However, doctors warn obese women that weight will continue to increase with hormone therapy.

Contraindications to taking the drug

Do not prescribe the drug Jeanine to women under the following conditions:

• The presence of tumors, both benign and malignant.

• Diabetes.

• Hypertension.

• Thromboembolic disease in the acute stage, or in history.

• Diseases of the liver.

• Epilepsy.

• Tendency to migraine.

In order not to aggravate the state of health, one should abandon the independent use of the drug Jeanine, not only for the treatment of endometriosis, but also for contraception. Before starting therapy, it is necessary to consult a doctor and undergo a qualitative diagnosis.

Feedback and recommendations

The drug Janine has passed many clinical trials that allow us to judge its effectiveness. Gynecologists-practitioners claim that Jeanine allows you to get rid of endometriosis in at least 85% of cases. Relapses of the disease occur in no more than 7% of women. Many of them are afraid to take hormonal drugs due to the fact that they contribute to weight gain. In fact, not every woman gains extra pounds. Moreover, the risks of obesity increase only with a sufficiently long and continuous use of the drug.

Positive feedback from women who took Jeanine for the treatment of endometriosis boils down to the elimination of the symptoms of the disease, the disappearance of pain. In addition, most of them note that the condition of the skin improves significantly.

So, Jeanine is a hormonal drug that allows you to get rid of endometriosis or reduce its manifestations. It has a contraceptive effect and can be used as an oral contraceptive. However, before starting treatment, it is necessary to consult a doctor.

Other positive effects of treatment with Jeanine:

• Menstrual function stabilizes.

• The duration of menstrual bleeding is reduced.

• The volume of blood lost returns to normal.

• The condition of the skin and hair improves. The amount of acne will decrease, the growth of hair on the face is noticeably reduced.

• The risk of malignancy of endometriosis foci is minimized.

Is it possible to get pregnant after the end of the course of treatment?

The drug is very often prescribed to women who cannot become pregnant due to endometriosis. After undergoing a prolonged course of treatment, the chances of conceiving and bearing a healthy child increase significantly. This phenomenon is called the rebound effect. It boils down to the fact that the ovaries wake up after “hibernation” due to the effect of hormonal drugs on them and begin to work hard. However, a woman should take into account that the chance of getting pregnant remains high for 2-3 months after stopping the drug. Then the work of the ovaries stabilizes. Although some doctors, on the contrary, recommend waiting for this period, fearing the fetal fading after prolonged contraception. Experts unanimously advise starting pregnancy planning against the background of absolute health and with a stable hormonal background.

It is worth considering that much depends on the age of the patient. The older she is, the longer it will take the reproductive system to recover.

Reviews of practicing gynecologists about taking the drug Janine by women suffering from endometriosis are very optimistic. Doctors are of the unanimous opinion that with a well-chosen treatment regimen, you can get rid of the disease and significantly improve the quality of life.