Isoprinosine to strengthen immunity. Composition, use, side effects

Isoprinosine is an antiviral drug with an immunostimulating effect (it stimulates the immune system response). It is indicated in infections of the skin and mucous membranes caused by Herpes simplex virus types 1 and 2 and Varicella zoster. The preparation is perfect for people with reduced immunity. The drug in the form of a syrup is available on prescription.

Isoprinosine, Producent: Ewopharma

Indications for the use of Isoprinosine

Isoprinosine is a syrup and its active substance is inosine pranobex. It is indicated in infections of the skin and mucous membranes caused by the virus Herpes simplex types 1 and 2 (herpes) and the virus Varicella zoster (chickenpox, shingles), as well as in other viral infections (e.g. subacute sclerosing encephalitis). As an adjunct, the preparation is indicated in people with reduced immunity.

Isoprinosine and contraindications

1. Hypersensitivity to any component of Isoprinosine,
2. do not use in people who currently have a gout attack or increased levels of uric acid in the blood,
3. Isoprinosine should not be used in pregnant women or in breast-feeding women, unless the doctor considers it absolutely necessary.

Dosage

Treatment usually lasts 5–14 days; the drug should be administered for 1-2 days after the symptoms disappear.

Isoprinosine in the form of a syrup

1. Adults: 50 mg / kg body weight daily, usually 3 g (60 ml of syrup) daily, divided into 3-4 doses. The maximum dose is 4 g per day (i.e. 80 ml of syrup per day).
2. Children after 1 year of age: 50 mg / kg body weight daily in 3-4 divided doses. Dosing schedule depending on the child’s weight: body weight 10-14 kg: 5 ml 3 times a day; body weight 15-20 kg: 5-7,5 ml 3 times a day; body weight 21-30 kg: 7,5-10 ml 3 times a day; body weight 31-40 kg: 10-15 ml 3 times a day; body weight 41-50 kg: 15-17,5 ml 3 times a day.

Use the measuring cup included in the package to measure the correct dose. In all age groups in severe infections (e.g. subacute sclerosing encephalitis in the acute phase of the disease) the dose may be increased to 100 mg / kg body weight daily in divided doses every 4 hours. The maximum dose is 4 g per day.

Isoprinosine in the form of tablets

1. Adults: 50 mg / kg body weight daily, usually 1 g (2 tablets) 3-4 times a day. Do not use more than 4 g (8 tablets) a day.
2. Children after 1 year of age: 50 mg / kg body weight daily in several divided doses. For children who cannot swallow tablets, a preparation in the form of a syrup is recommended.

In all age groups in severe infections (e.g. subacute sclerosing encephalitis in the acute phase of the disease) the dose may be increased to 100 mg / kg body weight daily in divided doses every 4 hours. Isoprinosine tablets should be washed down with plenty of fluid, preferably water. The tablet can be crushed and dissolved in a little water.

Isoprinosine – warnings

1. During treatment with Isoprinosine for 3 months or longer, uric acid levels in the blood and urine, liver function, blood count and renal function parameters should be regularly monitored.
2. Patients with hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take the preparation, because Isoprinosine syrup contains sucrose.
3. Patients with diabetes should note that the drug in the form of a syrup contains 650 mg of sucrose per ml.
4. Special caution is advised in patients who have ever been diagnosed or suspected of having gout, increased uric acid levels, urolithiasis (kidney stones) or impaired renal function. If the doctor prescribes the use of the drug for these patients, close monitoring of uric acid levels is necessary.
5. Isoprinosine tablets should not be taken by pregnant or breastfeeding women unless considered essential by your doctor.

Other Drugs and Isoprinosine

Be careful when taking medications such as:

1. allopurinol or other xanthine oxidase inhibitors;
2. drugs that increase the urinary excretion of uric acid, including diuretics (including thiazide diuretics such as, for example, hydrochlorothiazide, chlorthalidone, indapamide, and loop diuretics such as, for example, furosemide, torasemide, ethacrynic acid);
3. Isoprinosine should not be used while taking immunosuppressive drugs (suppressing the immune system response), such as certain drugs used after organ transplants or to treat atopic dermatitis;
4. The use of Isoprinosine in parallel with azidothymidine (AZT) enhances the effect of AZT.

Isoprinosine – side effects

Taking Isoprinosine can lead to side effects such as: nausea, vomiting, upper abdominal pain, increased liver enzymes, increased blood urea nitrogen, headache and dizziness, fatigue, malaise, joint pain, itching, rash. Uncommon: diarrhea, constipation, nervousness, somnolence, insomnia, increased urine volume.