Syn.: Microscopic polyarteritis, hypersensitivity angiitis.
Def .: Necrotising vasculitis with little or no immunoglobulin deposits (poor immune inflammation), affecting small vessels.
Etiol .: Exogenous antigens: microorganisms, drugs, chemicals and endogenous substances, eg DNA in systemic lupus, immunoglobulin in rheumatoid arthritis, antigens of tumor tissues.
Pat .: It belongs to the nodular arteritis spectrum and affects arterioles, capillaries and fine veins, especially in the kidneys and lungs.
Clinical: Kidney involvement occurs in 90% of cases (troubling glomerulonephritis), and over 50% of patients have alveolitis with hemorrhage. Skin changes occur in about 40% of patients in the form of purpura, urticarial eruptions, ulcerations.
DL: Biopsy shows small vessel fibrinous necrosis without granulomatous changes. There are pANCA antibodies, accelerated ESR, acute phase proteins, leukocytosis.
DR: Leukocytoclastic vasculitis.
Year: Serious due to renal and pulmonary complications.
Lit.: [1] Janette J.C., Falk R.J.: Small-vessel vasculitis. N Engl J Med 1997, 337; 1512-15. [2] Irvine A.D., Bruce I.N., Walsh M.Y. i wsp.: Microscopic polyangitis. Delineation of cutaneous-limited variant associated with antimyeloperoxidase antibody. Arch Dermatol 1997, 3; 133-77.
Source: A. Kaszuba, Z. Adamski: “Lexicon of dermatology”; XNUMXst edition, Czelej Publishing House