Ibuprom – action, indications, contraindications, side effects

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Ibuprom is an over-the-counter medicine that can be used to relieve pain of various origins and severity. Ibuprom is suitable for the relief of mild to moderate pain in the head, teeth, back, bones and joints. It can also be taken during painful periods and to lower a fever.

Ibuprom – action

Ibuprom is a systemic non-steroidal anti-inflammatory drug (NSAID). The active substance of the drug is ibuprofen, which belongs to the group of propionic acid derivatives. One tablet contains 200 mg of ibuprofen. The excipient is sucrose.

Ibuprofen has an analgesic, antipyretic and anti-inflammatory effect. Ibuprom prevents the synthesis of prostaglandins that are involved in the development of inflammation in the body. This is possible due to the inhibition of cyclooxygenase enzymes by ibuprofen, which are involved in processes which result in the formation of prostaglandins from lipids in cell membranes.

In this way, Ibuprom relieves the symptoms of inflammation, such as swelling, low-grade fever / fever and pain. Ibuprofen also inhibits platelet aggregation, but less and less rapidly than acetylsalicylic acid. Importantly, Ibuprom does not fight microorganisms.

Ibuprom is rapidly absorbed mainly in the small intestine and partly in the stomach. It has the highest concentration in the blood within 1-2 hours after administration. It is worth remembering that Ibuprom and its metabolites penetrate the placenta, and also in small concentrations are found in the milk of nursing mothers.

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Ibuprom – indications

The indication for the administration of Ibuprom is:

1. pain of various origins and mild or moderate intensity, such as pain in the head, teeth, muscles, bones and joints, and in the lumbosacral region;
2. painful menstruation;
3. fever, e.g. in the course of colds, flu or other infectious diseases.

Ibuprom – contraindications

In some cases, Ibuprom should not be used. A contraindication to the use of Ibuprom is hypersensitive (allergic) to the active substance or any of the ingredients of the drug.

Ibuprom is also not recommended for people who are allergic to acetylsalicylic acid, i.e. aspirin or other NSAIDs. Symptoms of hypersensitivity to these drugs include asthma attacks, the appearance of hives on the skin, and rhinitis.

Ibuprom is contraindicated in the case of:

1. active or past ulcer of the stomach and duodenum, bleeding or perforation (also after taking NSAIDs);
2. use of other NSAIDs (including COX-2 inhibitors) at the same time;
3. severe renal, hepatic or heart failure;
4. hemorrhagic diathesis;
5. third trimester of pregnancy;
6. children under 12 years of age.

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Ibuprom – precautions

In some diseases and other conditions, Ibuprom should not be used or a dose adjustment is required. Certain precautions should then be taken. In certain situations, it may be necessary to perform additional check-ups. It should be remembered that by using the lowest possible dose of Ibuprom that will give you relief for the shortest possible time, you can minimize the risk of side effects.

Ibuprom is a drug that should only be used for a short time. If symptoms persist after 3 days of taking the drug, see a doctor. It happens that while taking Ibuprom, the drug only masks the symptoms of infections, therefore, if a patient suspects that malaise is related to an infection, consult a doctor. It should be remembered that the drug does not fight microbes.

People suffering from the following diseases should take special precautions:

1. systemic lupus erythematosus or mixed connective tissue disease – Ibuprom increases the risk of developing aseptic meningitis;
2. gastrointestinal diseases reported by the patient in the history, incl. inflammatory bowel diseases such as ulcerative colitis, Crohn’s disease – Ibuprom can aggravate the disease;
3. high blood pressure, including heart problems (including problems in the past);
4. liver and / or kidney problems – Ibuprom may lead to swelling and water retention;
5. blood clotting disorders – Ibuprom may prolong bleeding time;
6. active or a history of bronchial asthma and allergic diseases – Ibuprom increases the risk of bronchospasm, which causes breathing difficulties and / or angioedema, making breathing difficult and life-threatening – if these symptoms appear, get medical help immediately;
7. people taking other medications at the same time;
8. the elderly – Ibuprom increases the risk of side effects. Elderly people should be especially careful and take the lowest possible dose of the drug for the shortest possible time. If an elderly person is suspected or diagnosed with any of the above conditions, he / she should consult a doctor before taking Ibuprom.

Ibuprom, like all NSAIDs, increases the risk of gastrointestinal haemorrhage, ulceration or perforation. This bleeding can be fatal. Unfortunately, there may not be any warning symptoms. Everyone is at risk at any stage of treatment. However, complications are more common among the elderly. Therefore, you should inform your doctor about any disturbing symptoms related to the digestive system. If bleeding occurs, stop taking the drug immediately and see your doctor.

People treating gastrointestinal diseases should use Ibuprom under medical supervision. They should use the lowest doses. The higher Ibuprom doses the older the person, the greater the risk of bleeding. People taking other medications that may have adverse effects on the digestive system (peptic ulcer disease, bleeding) should also be particularly careful. These drugs include corticosteroids, anticoagulants (warfarin), drugs that inhibit platelet aggregation (e.g. low doses of acetylsalicylic acid – aspirin), selective serotonin reuptake inhibitors. In some cases, the doctor may recommend the use of shielding drugs.

People with hypertension, congestive heart failure, fluid retention and edema, ischemic heart disease, peripheral arterial disease, cerebrovascular disease, or patients with risk factors for the above diseases should also be especially careful and use Ibuprom under medical supervision.

Ibuprom can also cause severe skin reactions that can even be fatal. It is i.a. Stevens-Johnson syndrome, toxic epidermal necrolysis or exfoliative dermatitis. However, these symptoms appear very rarely.

also use of Ibuprom may cause fertility problems in women, therefore it is not recommended in women planning to have a baby soon. However, these side effects are temporary and will disappear after your treatment is finished.

We should also remember that Ibuprom contains sucrose. People with family history of people suffering from fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase deficiency should refrain from taking Ibuprom.

There are no studies on the effects of Ibuprom on the ability to drive and use machines.

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Ibuprom – dosage

Ibuprom is available as film-coated tablets for oral use. To ensure safety while taking the drug, please follow the instructions in this leaflet. Increasing the dose on your own will not increase the effectiveness of the drug, and may be harmful to your health and even life-threatening.

Adults and children over 12 years of age may take 1-2 tablets (i.e. 200-400 mg) of Ibuprom every 4 hours. Importantly, the tablets should be taken after a meal. Do not exceed the daily dose of 1200 mg per day, which corresponds to 6 tablets in divided doses. Ibuprom can be used for no longer than 3 days without consulting a doctor. If after this time symptoms do not improve or worsen, see a doctor. Ibuprom is not given to children under 12 years of age.

Ibuprom – pregnancy and breastfeeding

During pregnancy, you should not take any medications without consulting your doctor. Before applying Ibuprom in pregnancy or while breastfeeding, consult your doctor to remove any doubts about the safety of its use.

Ibuprom should not be used by women in the third trimester of pregnancy due to the increased risk of closing the ductus arteriosus in the fetus, inhibition of uterine contractions and the development of renal failure in the fetus and mother. However, in the first and second trimesters, Ibuprom can only be used on the express recommendation of a doctor when the situation requires it. In each case, the doctor assesses the benefits and risks of administering Ibuprom and makes the final decision.

Ibuprom is also not indicated during breastfeeding.

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Ibuprom – interactions

Before taking Ibuprom, inform your doctor about all medications you are taking, including those available without a prescription. Do not take this medicine while taking:

1. acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (including COX-2 inhibitors, e.g. celecoxib, etoricoxib) – these drugs increase the risk of these side effects, especially gastrointestinal bleeding;
2. low doses of acetylsalicylic acid to inhibit platelet aggregation – Ibuprom may reduce the effect;
3. diuretics or antihypertensives – Ibuprom may reduce their effect and increase the risk of kidney damage;
4. anticoagulants, e.g. warfarin and drugs that inhibit platelet aggregation – Ibuprom may increase this effect and increase the risk of haemorrhage;
5. zidovudine – Ibuprom can prolong bleeding;
6. methotrexate and lithium – Ibuprom may increase the plasma concentration of these substances and intensify their toxic effect;
7. corticosteroids and serotonin reuptake inhibitors – Ibuprom increases the risk of side effects, especially gastrointestinal bleeding.

Ibuprom – side effects

Ibuprom can cause side effects, but it should be remembered that they will not occur in every person. Typically, the benefits of taking the drug outweigh the possible harm from its side effects.

Uncommonly, as a result of taking Ibuprom, the following appears:

1. indigestion;
2. stomach pain;
3. nausea;
4. Headache;
5. rash;
6. hives;
7. itching

Rarely or very rarely, the following occurs:

1. diarrhea;
2. flatulence;
3. constipation;
4. vomiting;
5. gastritis;
6. gastrointestinal bleeding (may be fatal);
7. pitchfork chair;
8. vomiting blood;
9. gastric and / or duodenal ulcer, also with perforation;
10. exacerbation of colitis or Crohn’s disease,
11. inflammation of the oral mucosa and esophagus;
12. inflammation of the pancreas;
13. liver disorders – most often as a consequence of long-term use;
14. swelling;
15. a small amount of urine output;
16. kidney failure;
17. renal papillary necrosis;
18. increase in the concentration of sodium in the blood plasma;
19. haematological disorders (including hemolytic and aplastic anemia, agranulocytosis, leukopenia);
20. arterial hypertension, heart failure, heart attack;
21. fatigue, dizziness;
22. sleep disturbance;
23. agitation, irritability, depression, psychotic reactions;
24. visual disturbances, tinnitus;
25. aseptic meningitis.

People struggling with systemic lupus erythematosus or a combination of connective tissue diseases have a higher risk of aseptic meningitis. Hypersensitivity and anaphylactic reactions may also occur, including life-threatening anaphylactic shock, angioedema, exacerbation of asthma and bronchospasm. Severe skin reactions may also occur, such as erythema multiforme, toxic epidermal necrolysis or Stevens-Johnson syndrome.

Before use, read the leaflet, which contains indications, contraindications, data on side effects and dosage as well as information on the use of the medicinal product, or consult your doctor or pharmacist, as each drug used improperly is a threat to your life or health.