Haloperidol Unia – indications, dosage, contraindications, side effects

Haloperidol Unia is a neuroleptic drug from the group of butyrophenone derivatives. The preparation has a calming and weak anti-autistic effect, while it has a strong antipsychotic effect. It lowers anxiety and psychomotor agitation. It also reduces nausea and hiccups. The drug is in the form of oral drops available from a prescription pharmacy.

Haloperidol Unia, Producer: Unia

Haloperidol Union indications for use

Adults:

1. schizophrenia (to treat symptoms and prevent them from returning),
2. other psychoses, especially paranoid ones,
3. mania and hypomania,
4. behavioral disorders (aggression, excessive mobility and a tendency to self-harm) in mentally handicapped people and in patients with organic brain damage,
5. Gilles de la Tourette’s syndrome and tics significantly disrupting functioning.

Children after 3 years of age.

1. behavioral disorders – especially aggressive behavior and excessive mobility,
2. Gilles de la Tourette syndrome,
3. childhood schizophrenia.

Dosage of the preparation Haloperidol Unia

Schizophrenia – Treat symptoms and prevent them from coming back. Other psychoses, especially paranoid ones. Mania and hypomania. Behavioral disorders: aggression, hypermobility and self-harm in mentally handicapped people and in patients with organic brain damage. Adjunctively in the short-term treatment of moderate to severe psychomotor agitation, violent and impulsive behavior.

1. Adults. Initially 1,5-3 mg 2-3 times / day (if symptoms are moderately severe) or 3-5 mg 2-3 times / day (if symptoms are severe or the patient does not respond to the drug), then the doctor may decide to increase doses, sometimes up to 30 mg / day; maintenance dose: 5-10 mg / day.

Restlessness and agitation in the elderly.

1. Adults. 1,5-3 mg 2-3 times / day; maintenance dose 1,5-30 mg / day.

Treatment-resistant hiccups.

1. Adults. Initially 1,5 mg three times / day; maintenance dose 3-1,5 mg / day.

Tourette’s syndrome and tics significantly disrupting functioning.

1. Adults. 1,5 mg three times / day; maintenance dose 3 mg / day.
2. Children after 3 years of age. The usual maintenance dose is up to 10 mg / day.

Behavioral disturbances (aggressive behavior, excessive mobility). Schizophrenia.

1. Children after 3 years of age. 25-50 mg / kg body weight / day in 2 divided doses; maximum dose 10 mg / day.

Haloperidol Unia and contraindications

Contraindications:

1. hypersensitivity to any component of the Haloperidol Unia preparation,
2. central nervous system depression,
3. coma states,
4. damage to the basal ganglia,
5. Parkinson’s disease,
6. clinically significant arrhythmias, e.g. recent acute myocardial infarction
7. decompensated heart failure,
8. arrhythmias treated with class IA and III antiarrhythmic drugs,
9. prolongation of the QT interval,
10. History of ventricular arrhythmia or torsade de pointes
11. bradycardia,
12. second and third degree heart block and decompensated hypokalaemia
13. parallel use of drugs that prolong the QT interval.

Haloperidol Union – warnings

1. Haloperidol Unia should be discontinued immediately and a doctor should be contacted if a fever develops, as it may be a symptom of a life-threatening neuroleptic malignant syndrome.
2. QT prolongation and / or ventricular arrhythmias accompanying rare cases of sudden death due to haloperidol may (rarely) occur.
3. Before starting haloperidol in patients at risk of developing ventricular arrhythmias, the doctor will consider the risk / benefit ratio (people with heart disease, family history of sudden death and / or QT prolongation, uncontrolled electrolyte disturbances such as hypokalaemia, hypocalcaemia, subarachnoid haemorrhage, alcohol dependence, malnutrition, especially at the beginning of treatment).
4. ECG tests for QT prolongation and severe arrhythmias should be performed during treatment with the drug if haloperidol is administered intravenously.
5. Haloperidol Unia should be used with caution in people whose metabolism by CYP2D6 is slower and during the use of cytochrome P450 inhibitors.
6. Concomitant use of other antipsychotics should be avoided.
7. Before starting the use of Haloperidol Unia, an ECG should be performed and repeated periodically during the treatment, depending on the needs.
8. The drug should be used with caution in patients with impaired thyroid function, with phaeochromocytoma, with epilepsy and in patients predisposed to convulsions (e.g. alcohol withdrawal and brain damage), with liver disease and renal failure.
9. The drug may affect your ability to drive and use machines.
10. Pregnant women may use the preparation only if the doctor deems it necessary.
11. Do not breastfeed while taking the drug.

Haloperidol Unia – side effects, including: coma, increase in serum creatine phosphokinase), dementia, slowness, headache, dizziness, agitation, insomnia, anxiety, somnolence, sedation, depression, confusion, seizures, worsening of psychotic symptoms, nausea, loss of appetite, constipation, dyspepsia, hyperprolactinemia , galactorrhoea, oligomenorrhoea, amenorrhea, gynaecomastia, erectile and ejaculation disorders, hypoglycaemia, excessive antidiuretic hormone secretion, hypotension (especially in the elderly), tachycardia, dry mouth, increased salivation, blurred vision , urinary retention, excessive sweating, skin rashes, erythema multiforme, exfoliative dermatitis, increase / decrease in body temperature, extrapyramidal symptoms (increased muscle tone, hypersalivation, slowness of movement, tremor, maskiness, akathisia, dystonias, bouts of compulsive gazing) With rotation of the eyeballs, laryngeal dystonia), tardive dyskinesia, acute dyskinesia, neuroleptic malignant syndrome (motor inhibition, increased skeletal muscle tone with tremors and involuntary movements, akathisia, high central body temperature, dysfunction of the autonomic system, disorders.