The test measures S-transferases – detoxification enzymes found in the cells of the renal tubules. The α-GST isoenzyme is present in the cells of the proximal urethra, and the α-GST – in the cells of the distal urethra. When the tubular cells are damaged, these enzymes are released into the urine.
When do we do a urine GST test?
The most common indications for the examination.
1. Assessment of drug nephrotoxicity.
2. Assessment of the degree of kidney damage due to ischemic changes.
3. Assessment of the viability of the transplanted kidney.
Glutathione s-transferase study
Material for the GST test: urine.
The course of the study: XNUMX-hour urine collection.
Time to wait for the result: several days.
Standards:
– α-GST – less than 12 µg per day,
– π-GST – below 50 µg per day.
Comments: The determination of transferase isoenzymes allows to locate the level of damage to the renal tubular cells.