The gene that inhibits the development of tumors is the p53 gene. However, its mutation has a growth stimulating effect tumor tissue. Mutated p53 also causes cancer malignancy, treatment resistance and relapse. Recent studies have shown a relationship between the amount of glucose ingested and the level mutant p53. The original aim of the research was to understand how to reduce the level of proteins generated by the mutated p53 gene present in tumors. Many scientists claim that current chemotherapy even increases this level. Scientists have studied the relationship between autophagy and reducing glucose levels in the diet. Autophagy is the process by which damaged organelles and mutated proteins are removed from the cell. Well, it turned out that mutant p53 proteins are effectively killed only when autophagy is driven by glucose reduction. In the first phase of the experiment, the researchers compared the response of two mice with mutated p53 to carbohydrates (glucose). diet containing little carbohydrates caused a significant decrease in mutant p53 in mouse tissues (and vice versa). Then, it was necessary to demonstrate the relationship between this phenomenon and the growth of neoplastic tumors. For this purpose, mice were implanted with human lung cancer cells. It was consequently found that the growth of the tumor cells took place when the mouse was fed a diet high in carbohydrates.
2022-11-10