Used for the short-term treatment of mild to moderate pain and fever in patients who cannot take paracetamol by mouth because of nausea or vomiting.
Gemipar 50, -125, -500 (Boat)
| form, dose, packaging | availability category | the active substance |
| suppositories 0,05 g, 0,125 g, 0,5 g (10 suppositories) | OTC (over-the-counter) | paracetamol (paracetamol) |
ACTION
Non-opioid drug with analgesic and antipyretic properties
INDICATIONS AND DOSAGE
Short-term treatment of mild to moderate pain. Fever in patients who cannot take paracetamol by mouth because of nausea or vomiting. Kids. Rectally. 10-15 mg / kg bw every 4 h, not more often than 4 × / d; usually children 3-6. m 50 mg once, 7-12. m – 50-100 mg once. 1.-3. at the age of 125 one-off, 3rd – 6th. years – 125–250 mg once. Adults and children after 12 years of age. 500 mg every 4 h, not more frequently than 4 times a day.
CONTRAINDICATIONS
Hypersensitivity to any component of the preparation, severe renal or hepatic failure, congenital deficiency of glucose-6-phosphate dehydrogenase and methaemoglobin reductase, alcoholism, XNUMXst trimester of pregnancy.
WARNINGS
Due to the risk of overdose, other paracetamol preparations should not be used concomitantly. Do not use doses higher than recommended due to the risk of severe liver damage. Caution should be exercised in patients: allergic to acetylsalicylic acid derivatives (risk of allergic reaction); with hepatic and / or renal failure; dehydrated or malnourished; patients with alcoholism; Elderly. People who are hungry and consume alcohol regularly are at particular risk of liver damage. Alcohol must not be consumed during treatment. Use of the preparation in women in the second or third trimester of pregnancy and during breastfeeding only after consulting a doctor and only if absolutely necessary. Use in the first trimester of pregnancy is contraindicated.
INTERACTIONS
Paracetamol enhances the effect of coumarin derivative anticoagulants, which may increase the risk of haemorrhage. Paracetamol may increase the toxic effects of chloramphenicol. Salicylamide increases the elimination time of paracetamol. Do not use with MAO inhibitors or within 14 days from the end of treatment with these preparations due to the possibility of agitation and high fever. The use of drugs that increase hepatic metabolism, such as rifampicin, antiepileptics, sleeping pills (barbiturates) or the consumption of alcohol can cause toxic damage to the liver, even when using the recommended doses of paracetamol. The use of paracetamol and non-steroidal anti-inflammatory drugs increases the risk of renal dysfunction. Phenytoin may reduce the effectiveness of paracetamol and increase the risk of liver toxicity. Exercise caution when using zidovudine as it may increase its myelotoxicity. The use of paracetamol may affect the results of laboratory tests, for example, the determination of blood glucose or uric acid levels.
SIDE EFFECTS
Rarely may occur: malaise, drop in blood pressure, allergic reactions (pruritus, urticaria, rash, erythema, angioedema, asthma attack), increased heart rate, nausea, vomiting, diarrhea, impaired liver and kidney function (up to renal failure) and liver), increased levels of hepatic transaminases, thrombocytopenia, leukopenia, neutropenia. Very rarely, symptoms of an anaphylactic shock.