Fromilid UNO – 500 mg tablets, dosage, side effects

Fromilid UNO is an antibacterial drug for general use. Macrolide antibiotic used to treat bacterial infections. It helps heal upper and lower respiratory tract infections, skin infections, and cellulitis. Fromilid UNO is available on prescription in the form of modified-release tablets.

Fromilid UNO, Producer: Krka

Indications for taking Fromilid UNO

Fromilide UNO is available on prescription, it is used in the treatment of the following infections caused by microorganisms sensitive to clarithromycin: upper respiratory tract infections (e.g. pharyngitis caused by streptococci), acute otitis media, lower respiratory tract infections (e.g. bronchitis, pneumonia), skin and subcutaneous tissue infections (e.g. folliculitis, cellulitis and erysipelas) ).

Fromilid UNO and contraindications

Contraindications to taking Fromilid UNO are:

1. hypersensitivity to any component of the preparation or to other macrolide antibiotics.
2. During treatment with clarithromycin, the use of any of the following drugs is contraindicated: astemizole, cisapride, pimozide, terfenadine, ergotamine or dihydroergotamine.
3. This form of the preparation (modified-release tablets) is contraindicated in people with impaired renal function and a creatinine clearance less than 30 ml / min, due to the lack of dose reduction (tablets cannot be divided).
4. The use of the preparation is contraindicated in people with severe liver failure.

Dosage

Adults:

1. The usual dose is 500 mg once a day. In more severe infections, the doctor may increase the dose to 1 g once a day. Treatment usually lasts 1-1 days, and 5-14 days in pneumonia and sinusitis.

Kids:

1. There are no data on the safety and effectiveness of the preparation in children.

In people with moderate renal insufficiency (creatinine clearance less than 60 ml / min but greater than 30 ml / min), it is necessary to adjust the dosage of Fromilid UNO by a doctor. In this group of patients, the preparation should not be used for more than 14 days. In the case of people with severe renal insufficiency (creatinine clearance less than 30 ml / min), the use of the preparation is contraindicated, as the dose cannot be reduced (tablets cannot be divided). These patients will be advised by the doctor to use other forms of the preparation. Fromilid UNO tablets should be taken orally, swallowed whole (the tablets must not be divided or chewed). Taken with a meal.

Fromilid UNO – preparation warnings

1. Prolonged use of Fromilid UNO may increase the number of non-susceptible bacteria and fungi.
2. People with galactose intolerance, lactase deficiency or malabsorption of glucose-galactose should not use this preparation because it contains lactose.
3. Fromilid UNO contains sodium, which should be borne in mind for people on a low-sodium diet.
4. Caution should be exercised in the case of: people with severe renal insufficiency, people with hepatic impairment, people with myasthenia gravis, elderly people and people with renal insufficiency, using colchicine in parallel, parallel use of other ototoxic drugs, people with coronary heart disease, severe heart failure cardiac activity, hypomagnesaemia, bradycardia (<50 beats per minute).
5. Pregnant women should consult a doctor before taking Fromilid UNO.
6. The clarithromycin contained in the preparation passes into breast milk.
7. Do not give the drug to persons under 12 years of age. age.
8. It should not be used in patients with congenital or documented acquired QT prolongation or with a history of ventricular arrhythmias.

Fromilid UNO and other drugs

You should not take Fromilid UNO simultaneously with the following drugs:

1. cyzapryd, pimozyd, astemizol i terfenadyna;
2. ergotamine and dihydroergotamine;
3. cytochrome P-450 inducers (e.g., rifampicin, phenytoin, carbamazepine, phenobarbital, St. John’s wort, efavirenz, nevirapine and rifapentine);
4. ryfabutyna;
5. rytonawir;
6. drugs metabolized mainly by cytochrome P-450 (alprazolam, astemizole, carbamazepine, cilostazol, cisapride, cyclosporine, disopyramide, ergot alkaloids;
7. lovastatin, methylprednisolone, midazolam, omeprazole, oral anticoagulants, pimozide, quinidine, rifabutin, sildenafil, simvastatin, sirolimus, tacrolimus, terfenadine, triazolam and vinblastine, phenytoin, theophylline and valproate);
8. anti-arrhythmic drugs (e.g. quinidine, disopyramide);
9. inhibitory fosfodiesterazy;
10. theophylline, carbamazepine, tolterodyna;
11. intravenous midazolam, triazolam, alprazolam;
12. kolchicina;
13. digoxin;
14. zydowudyna;
15. phenytoin and valproinian;
16. atazanawir;
17. itraconazole;
18. verapamil.

Fromilid UNO and possible side effects

During the treatment with the drug, the following may occur: candidiasis, gastroenteritis, vaginal infection, leukopenia, hypersensitivity, anorexia, decreased appetite, anxiety, peripheral dizziness, headache, change in taste, diarrhea, vomiting, indigestion, nausea, abdominal pain, chest pain, chills, fatigue, blood alkaline phosphatase increased, blood lactate dehydrogenase increased, thrombocytopenia, anaphylactic reaction, hepatocellular jaundice, Stevens-Johnson syndrome, toxic epidermal necrolysis.