Fromilid 250, -500 – antibacterial drug for general use. How to dose?

Fromilid 250, -500 is an antibacterial drug for general use. Macrolide antibiotic used to treat bacterial infections. It is used in tonsillitis and pharyngitis, bronchitis or in infections caused by mycobacteria. The drug is available on prescription in the form of film-coated tablets.

Fromilid 250, -500, Producer: Krka

Indications for taking Fromilid 250, -500

Treatment of the following infections caused by clarithromycin-sensitive microorganisms:

1. tonsillitis and pharyngitis caused by streptococci,
2. acute maxillary sinusitis,
3. acute otitis media,
4. exacerbation of chronic bronchitis,
5. pneumonia,
6. uncomplicated skin and soft tissue infections,
7. generalized infections caused by mycobacteria,
8. eradication Helicobacter pylori in patients with peptic ulcer disease (in combination with other drugs).

Fromilid 250, -500 and contraindications

Contraindications to the use of Fromilid 250, -500 are:

1. hypersensitivity to any component of the preparation or other macrolide antibiotics,
2. during treatment with clarithromycin, the use of any of the following drugs is contraindicated: astemizole, cisapride, pimozide, terfenadine, ergotamine or dihydroergotamine.
3. Do not use in patients with a history of QT prolongation on the ECG or ventricular arrhythmias including torsades de pointes.
4. Do not take in parallel with HMG-CoA reductase inhibitors (statins): lovastatin or simvastatin.
5. Do not use in people with hypokalaemia (low blood potassium).

Dosage

Adults and children over 12 years of age:

1. The usual dose is 250 mg every 12 hours. For sinusitis, more severe infections and infections caused by bacteria Hemophilus influenzae 500 mg is used every 12 hours. Treatment usually lasts 7-14 days. In eradication Helicobacter pylori in patients with peptic ulcer disease (in combination with other drugs): 500-1500 mg daily, usually in 2 doses over 7-14 days.
2. In the case of mild or moderate hepatic impairment and renal function is not impaired, no dosage adjustment is necessary.
3. In people with renal insufficiency (creatinine clearance less than 30 ml / min), it is necessary to adjust the dosage by the doctor (usually the doctor will recommend 250 mg once a day, or 1 mg every 250 hours in the case of more severe infections).

Fromilid 250, -500 tablets should be taken orally, swallowed whole (tablets should not be divided) with liquid.

Fromilid 250, -500 – warnings

1. Special care should be taken in the case of: people with severe renal insufficiency, people with hepatic impairment, especially in the coexistence of moderate or severe renal dysfunction, people with myasthenia gravis, elderly people and with renal failure, using colchicine in parallel, using other medications in parallel with ototoxic effects (parallel), people with coronary heart disease, severe heart failure, hypomagnesaemia, bradycardia (<50 beats per minute), use of drugs inducing the cytochrome P-3 isoenzyme CYP 4A450 (parallel).
2. Before taking Fromilide 250, -500 for the treatment of community-acquired pneumonia, as well as for the treatment of mild to moderate skin and soft tissue infections, your doctor will perform an antibiotic susceptibility test.
3. Taking the preparation to treat Helicobacter pylori infection may cause the development of drug-resistant microorganisms.
4. Pregnant women should consult a doctor before taking the drug.
5. The clarithromycin contained in the drug passes into breast milk.
6. It should not be used in people with congenital or documented acquired QT prolongation or with a history of ventricular arrhythmias.

Fromilid 250, -500 – side effects

Fromilid 250, -500 can cause, among others: insomnia, taste disturbance, headache, changes in taste, diarrhea, vomiting, indigestion, nausea, abdominal pain, liver function test abnormal, rash, sweating. In addition, with an unknown frequency, the following may occur: pseudomembranous colitis, colitis, erysipelas, erythematous dandruff, agranulocytosis, thrombocytopenia, anaphylactic reaction, hypoglycaemia, psychotic disorders, confusional states, depersonalisation, depression, hallucinations, disorientation, abnormal dreams, convulsions, lack of taste, sense of smell, lack of smell , deafness, torsades de pointes, ventricular tachycardia, haemorrhage, acute pancreatitis, tongue discoloration, tooth discoloration, liver failure, hepatocellular jaundice, Stevens-Johnson syndrome, toxic epidermal necrolysis.