Fluconazole Polfarmex (leaflet) – syrup, dosage of the drug

Fluconazole Polfarmex is an antifungal drug from the group of triazole derivatives for systemic use. It is indicated in the treatment of infections of the mouth, esophagus or in the prevention of recurrence of cryptococcal meningitis in patients with AIDS. Fluconazole as the active substance of the drug passes into breast milk. The preparation is available on prescription in the form of a syrup.

Fluconazole Polfarmex, Manufacturer: Polfarmex

Indications for taking Fluconazole Polfarmex

Treatment of the following infections:

1. vaginal candidiasis,
2. oral and esophageal candidiasis,
3. systemic candidiasis (candidemia, disseminated candidiasis, pulmonary candidiasis, urinary tract and peritoneal candidiasis),
4. cryptococcal meningitis,
5. mycoses of the skin (including feet, torso, shins),
6. dermal candidiasis, when systemic treatment is recommended,
7. Tinea versicolor, when systemic treatment is recommended,
8. onychomycosis when other medications are inappropriate.
9. Prophylaxis of candidiasis in patients after bone marrow transplantation and in patients undergoing chemotherapy and / or radiotherapy.
10. Prevention of recurrence of cryptococcal meningitis in patients with AIDS.

Polfarmex Fluconazole and contraindications

Contraindications to taking Fluconazole Polfarmex are:

1. hypersensitivity to any component of the preparation or other preparations from the group of azole derivatives,
2. parallel intake of astemizole, cisapride, pimozide, quinidine and terfenadine.

Dosage of Fluconazole syrup

Adults and children over 13 years of age:

1. Vaginal candidiasis. 150 mg (30 ml of syrup) once. Use in children under 16 years of age is not recommended due to insufficient data, except in the absence of alternative treatments.
2. Oral candidiasis: 50 mg (10 ml of syrup) once a day, in severe cases 1 mg (100 ml of syrup) once a day for 20-1 days.
3. Esophageal candidiasis: 50 mg (10 ml of syrup) once a day, in severe cases 1 mg (100 ml of syrup) once a day, usually for 20-1 days.
4. Systemic candidiasis (candidemia, disseminated candidiasis, pulmonary candidiasis, urinary and peritoneal candidiasis): 400 mg on the first day (80 ml of syrup), then 200 mg (40 ml of syrup) daily. Depending on the clinical response, your doctor may increase the dose to 400 mg (80 ml of syrup) daily. The duration of treatment depends on the clinical response.
5. Cryptococcal meningitis: 400 mg (80 ml of syrup) on the first day, then 200-400 mg (40-80 ml of syrup) once daily. Duration of treatment depends on clinical response, usually at least 6-8 weeks.
6. Mycoses of the skin (including the feet, torso, lower legs), dermal candidiasis, when systemic treatment is recommended: 150 mg (30 ml of syrup) 1 × / week or 50 mg (10 ml of syrup) 1 × / day for 2-4 weeks, in athlete’s foot – up to 6 weeks
7. Tinea versicolor, when systemic treatment is recommended: 300-400 mg (60-80 ml of syrup) 1x / week for 7-21 days or 50 mg (10 ml of syrup) 1x / day for 14-28 days.
8. Onychomycosis when other medications are inappropriate. 150 mg (30 ml of syrup) once a week, until the infected nail is replaced with a new one.
9. Prevention of recurrence of cryptococcal meningitis in patients with AIDS: 100-200 mg (20-40 ml of syrup) daily.
10. Prevention of candidiasis in immunocompromised patients after chemo- and / or radiotherapy: depending on the risk of infection 50-400 mg (10-80 ml of syrup) once a day.
11. Prevention of candidiasis in patients after bone marrow transplantation: 400 mg (80 ml of syrup) once a day (the doctor will start treatment a few days before the expected occurrence of neutropenia and recommend continuing treatment for 1 days after reaching a number of neutrophils greater than 7 in a microliter of blood).

The safety and efficacy of the preparation in children from 6 months of age – 13 have not been established. age. Therefore, the doctor may recommend the use of Fluconazole Polfarmex in this age group only if absolutely necessary and if the kidney function is normal.

Fluconazole Polfarmex – warnings

1. Consult your doctor before taking Fluconazole Polfarmexje if you have had hypersensitivity reactions to drugs or other allergens.
2. People with hereditary disorders related to fructose intolerance, malabsorption of glucose-galactose or sucrase-isomaltase deficiency should not use the preparation because the preparation contains sorbitol.
3. In patients with any liver dysfunction, the doctor will regularly check the parameters of the liver function before and during treatment.
4. In people with congenital or acquired prolongation of the QT interval on the ECG, with cardiomyopathy, especially in the case of heart failure, with sinus bradycardia, with arrhythmias, in people taking concurrent medications affecting the prolongation of the QT interval, with electrolyte disturbances (especially low blood levels). potassium, magnesium or calcium), there is an increased risk of arrhythmias with fluconazole treatment.
5. Do not take Fluconazole Polfarmex during pregnancy.
6. The preparation passes into breast milk. Do not use during this period.
7. The fluconazole contained in the drug has numerous interactions with other drugs used in parallel, in many cases which may lead to the occurrence of serious side effects.

Fluconazole Polfarmex and possible side effects

During the use of the drug, the following may appear: itching, rash, hair loss, sometimes severe reactions (urticaria, angioedema, including the face, larynx, glottis that may obstruct breathing, anaphylactic reactions and anaphylactic shock, severe skin reactions: Stevens-Johnson syndrome, toxic necrosis, erythema multiforme exfoliative dermatitis), nausea, vomiting, diarrhea, abdominal pain, indigestion in some patients, especially those with AIDS or neoplastic diseases, changes in the parameters of the liver and / or kidneys as well as changes in hematological and biochemical parameters may occur.