Used in pain of various origins of low or medium intensity, fever, symptomatic treatment of flu-like conditions and colds.
Efferalgan Vitamin C (Bristol-Myers Squibb Polska/Ozone Laboratories)
| form, dose, packaging | availability category | the active substance |
| tabl. Mus. (10 tabs., 20 tabs.) | OTC (over-the-counter) | ascorbic acid, paracetamol (ascorbic acid, paracetamol) |
SUBSTANCE 1 tablet contains: 0,33 g of paracetamol, 0,2 g of ascorbic acid
ACTION
Combined preparation with analgesic and antipyretic properties
INDICATIONS AND DOSAGE
Pain of various origins of low or moderate intensity, fever, symptomatic treatment of flu-like conditions and colds. Orally, tabl. dissolve in a little liquid. Adults and children after 15 years of age (> 50 kg bw) 1-2 tables every 4-6 h (max. 9 tablets / day, in case of very severe pain – max. 12 tablets / day). Kids. Usually 60 mg / kg bw / d in 4-6 doses. division (15 mg / kg bw every 6 h or 10 mg / kg bw every 4 h): 27–30 kg bw. 1 tablet every 6 h (max. 5 tablets / day); 30–35 kg bw 1-2 tablets every 6 h (max. 6 tablets / day); 35-50 kg bw 1-2 tablets every 4 h (max. 7 tablets / day). Do not use more often than every 4 hours (in renal failure every 8 hours).
CONTRAINDICATIONS
Hypersensitivity to any component of the preparation, 6st trimester of pregnancy, severe liver or kidney failure, alcoholism, glucose-14-phosphate dehydrogenase deficiency, use of MAO inhibitors in parallel or within the last 1 days, simultaneous use of opioid painkillers with agonist-antagonistic effect (e.g. buprenorphine, nalbuphine, pentazocine), nephrolithiasis in the case of vitamin. C in doses> 27 g. Do not use in children
WARNINGS
Do not use for more than 10 days in the case of pain and no longer than 3 days in the case of colds or flu in adults without the recommendation of a doctor; in children, not always longer than 3 days. In order to avoid overdose, check that other medications do not contain paracetamol. Do not use doses higher than recommended due to the risk of severe liver damage. Symptoms of liver damage usually appear 2 days after drug administration, and their maximum intensity usually occurs 4-6 days after drug administration. In the event of any suspicion of liver damage, you should immediately consult a doctor who will administer appropriate treatment. People who are hungry and consume alcohol regularly are at particular risk of liver damage. You must not drink alcohol or any drugs containing alcohol during treatment (risk of toxic liver damage). 1 tablet contains 330 mg of sodium, which should be taken into account by people on a low-sodium diet. The preparation contains sorbitol; it should not be used by people who are fructose intolerant. Caution should be exercised when using the preparation in people with hepatic and / or renal insufficiency (creatinine clearance <30 ml / min), patients with alcoholism, malnourished, hungry or dehydrated. Use of the preparation in women in the second or third trimester of pregnancy and during breastfeeding only after consulting a doctor and only if absolutely necessary. Use in the first trimester of pregnancy is contraindicated.
INTERACTIONS
Paracetamol enhances the effect of coumarin derivative anticoagulants. Salicylamide increases the elimination time of paracetamol. Do not use with MAO inhibitors or within 14 days from the end of treatment with these preparations due to the possibility of agitation and high fever. The use of drugs that increase hepatic metabolism, such as rifampicin, antiepileptics, sleeping pills (barbiturates) or the consumption of alcohol may cause toxic damage to the liver, even when using the recommended doses of paracetamol. The use of paracetamol and non-steroidal anti-inflammatory drugs increases the risk of renal dysfunction. Phenytoin may reduce the effectiveness of paracetamol and increase the risk of liver toxicity. Probenecid reduces the excretion of paracetamol. Take caution when administering isoniazid or zidovudine. The use of paracetamol may affect the results of laboratory tests, for example, the determination of blood glucose or uric acid levels.
SIDE EFFECTS
Rarely, the following may occur: malaise, drop in blood pressure, allergic reactions (itching, urticaria, rash, erythema), increased heart rate, nausea, vomiting, diarrhea, impaired liver and kidney function (up to complete renal and hepatic failure), increased activity hepatic transaminases, thrombocytopenia, leukopenia, neutropenia. Very rarely anaphylactic reactions (angioedema, bronchospasm, dyspnoea, hypotension, symptoms of anaphylactic shock, Quincke’s edema). High doses of ascorbic acid (greater than 1 g / day) may increase the risk of oxalate and gout stones. The use of vitamin C in patients with glucose-6-phosphate dehydrogenase deficiency may cause haemolytic anemia.