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Any drug applied systemically or topically may cause an allergic skin disease. Therefore, one should not use any medications without a significant need, e.g. prophylactically, for a trial, etc.
Even vitamins and antiallergic drugs can trigger an allergy!
Some of these rashes are not characteristic, e.g. they are urticaria, macular, papular, haemorrhagic or vesicular changes. Particular attention should be paid to the 3 units from the erythematous group discussed below.
Erythema exudative multiforme
This form of erythema can be either infectious or drug-induced. Among the symptoms of fever and malaise there are erythema on the skin and mucous membranes with blisters and then erosions. In severe varieties, the disease can be fatal. It is necessary to discontinue the drug immediately and see a doctor.
Nodular erythema
Erythema nodosum can also be post-infection or drug-induced. Symptoms include fever, inflammatory bumps on the front surface of the lower legs, and less often also the thighs and upper extremities. Tumors are painful under pressure, never ulcerating.
Persistent erythema
Always drug-induced. After application of the drug, erythema appears anywhere on the skin, from 1 cm to several centimeters in diameter, slightly above the level of the surrounding skin, itchy. Gradually, the efflorescence turns brown and then resolves to come back exactly in the same place when the same medication is used again. In the case of long-term use, the changes may turn into exudative erythema.