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Detreomycin is an ointment drug that is used in dermatology for topical treatment. The active substance of the preparation is chloramphenicol. The preparation is available on prescription.
Detreomycin – composition and action
The active ingredient in Detreomycin is chloramphenicol. 1 g of ointment contains 20 mg of chloramphenicol. The other ingredients are: white petroleum jelly, lanolin, peanut oil.
Thanks to him, the properties of the drug Detreomycin are bactericidal and bacteriostatic.
Chloramphenicol is active against gram-negative and gram-positive bacteria, spirochetes and rickettsiae. Chloramphenicol is active against Haemophilus influenzae, Salmonella spp., Neisseria spp., Klebsiella spp., Streptococcus pneumoniae and anaerobic bacteria (moderately against Bacteroides fragilis, strongly against Propionibacterium acnes).
In addition, the active substance in Detreomycin is active against Staphylococcus spp., Streptococcus pyogenes, Escherichia coli, Proteus mirabilis, Shigella spp., Serratia marcescens, Mycoplasma spp., Rickettsia spp., Chlamydia spp.
Pseudomonas aeruginosa, acid-resistant mycobacteria, some bacillus are resistant to the action of chloramphenicol.
See also: What does the presence of neisseria spp mean?
Detreomycin – indications
The indications for use are described in the Detreomycin leaflet. The drug is used in the topical treatment of purulent skin diseases that are infected with bacteria resistant to the action of other antibiotics.
Detreomycin – dosage
The drug is applied topically, on the skin – as prescribed by the doctor. A small amount of the drug should be squeezed onto gauze and then applied to clean and dry skin with lesions. The operation can be repeated 1-3 times in 24 hours, with an interval of 6-8 hours between individual applications.
Detreomycin is not recommended for use for more than two weeks.
Wash your hands after using Detreomycin.
Check with your doctor or pharmacist if you are not sure.
If you use more than the prescribed dose of Detreomycin, please contact your doctor.
Do not use a double dose to make up for a forgotten dose. If a dose is missed, the drug should be used as soon as possible. Then continue treatment with the usual dosage prescribed by your doctor.
Also check: How do you wash your hands thoroughly to get rid of viruses?
Detreomycin – contraindications to the use of the drug
The preparation is not used in the case of:
- liver function disorders,
- allergic to any ingredient of the drug,
- pregnancy and breastfeeding,
- abnormalities in blood counts,
- kidney problems,
- hematopoiesis disorders,
- bone marrow diseases,
- the patient’s allergy to peanuts and soy, because the preparation contains peanut oil.
The ointment is also not recommended for preventive treatment.
The preparation is not allowed for children and adolescents under 18 years of age.
Also read: Symptoms of a sick liver – how to recognize? [WE EXPLAIN]
Detreomycin – warnings
The drug should not be used for longer than necessary. Using it for more than 14 days, or in the case of large lesions, may increase the risk of severe side effects.
Treatment with drugs containing chloramphenicol should not be restarted. You can also not use the preparation with drugs that suppress bone marrow function.
Detreomycin has no influence on the ability to drive and use machines.
Do not use with drugs that may cause interactions.
Detreomycin should be stored below 25 ° C, out of the sight and reach of children.
Detreomycin should not be used after the expiry date stated on the package. The expiry date refers to the last day of that month.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to throw away medicines no longer required. Such behavior will help to protect the environment.
Also read: Medications that are stored wrongly are poisonous
Detreomycin – interactions
Tell your doctor about all the medicines you are taking, or have recently taken, and about any medicines you plan to take.
Chloramphenicol cannot be taken simultaneously with penicillins, cephalosporphins, as antagonistic effects may occur.
Chloramphenicol should not be administered with macrolide antibiotics, as they have the same mechanism of action (damage to protein synthesis, binding to the same site in the ribosome).
Chloramphenicol is an inhibitor of microsomal enzymes, therefore it intensifies and prolongs the action of preparations metabolized in the liver (e.g. warfarin, phenytoin, tolbutamide, chlorpropamide, cyclophosphamide, which may cause severe toxic effects of these drugs).
The drug should not be used simultaneously with erythromycin, as a competitive mechanism of action of these preparations may appear.
Chloramphenicol interferes with the synthesis of vitamin K, therefore close monitoring of the prothrombin time is necessary in patients taking concomitant anticoagulants.
Chloramphenicol enhances the blood sugar-lowering (hypoglycaemic) effect of sulfonylureas, increases the concentration and prolongs the half-life of dihydroxycoumarin derivatives in the blood, and significantly increases the toxic effects of many drugs on the haematopoietic system, e.g. phenylbutazone, indomethacin and cotrimoxazole.
Interactions with other topical agents are not known.
Detreomycin and pregnancy and breastfeeding
Before taking Detreomycin, if you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice.
Detreomycin should not be used during pregnancy and breastfeeding.
Detreomycin – side effects
Like all drugs, Detreomycin can cause side effects, but not everybody gets them. While taking Detreomycin, the following may occur:
- irritation in the form of itching, stinging, redness (which are an indication for drug discontinuation, i.e. urticaria, erythema),
- angioneurotic edema,
- dermatitis,
- skin allergic reactions,
- yeast superinfection.
In rare cases, bone marrow damage, including aplastic anemia, and abnormal blood composition have been reported.
If you get any side effects, including any side effects not listed, contact your doctor immediately.
Detreomycin – reviews
Opinions about Detreomycin vary. It is worth getting acquainted with them before using the preparation, and then consult a doctor if in doubt.