Cyclonamine – action, dosage, indications and contraindications, side effects

Proven content

Cyclonamine is a haemostatic drug that works by stopping bleeding and sealing blood vessels. It is a prescription preparation, and its active substance is etamsylate. What are the indications and contraindications for the use of this drug? How should this preparation be dosed? Can its use cause side effects in a patient? How much does Cyclonamine cost?

Cyclonamine – drug characteristics

Cyclonamine is a prescription drug available from pharmacies. It works by stopping bleeding and sealing blood vessels. The active ingredient of Cyclonamine is etamsylat, i.e. a drug with an antihaemorrhagic effect.

Cyclonamine is available in pharmacies in three variants:

1. hard capsules 500 mg;
2. 250 mg tablets;
3. solution for injection 250 mg / 2 ml (12,5%).

Cyclonamine, available as hard capsules, can be sold in packs of 30, 60 or 90 capsules. Cyclonamine capsules are cylindrical-oval, closed, two-piece and orange in color. There is a white to almost white powder in the center of the capsule.

The manufacturer and entity responsible for the distribution of Cyclonamine is Farmaceutyczna Spółdzielnia Pracy “GALENA”. Galena was founded in 1946. It is a manufacturer of antihistamines, cardiology and painkillers. The assortment of this concern also includes vitamin preparations, probiotics, preparations for immunity and ophthalmic preparations. FSP “Galena” also provides services in the field of the synthesis of pharmaceutical substances.

What is a hemorrhage and how do you stop it? Check: Haemorrhage

Cyclonamine – composition and action of the drug

The main ingredient that determines the therapeutic properties of Cyclonamine is etamsylate. Etamsylate is an organic chemical compound from the group of sulfonates with a hemostatic effect.

Etamsylate significantly shortens the bleeding time and has no effect on the prothrombin time. It also affects the initial stage of stopping bleeding. This compound increases the strength of capillary walls, and also reduces their permeability and brittleness. At the same time, it does not constrict the lumen of the blood vessels.

Orally administered etamsylate shows maximum effect after approximately 3 hours. This effect lasts up to 4-6 hours. Binds 95% with blood plasma proteins. It is not metabolized. It is mainly excreted unchanged in the urine. It is a drug supporting hemostatic therapy.

The full composition of the drug Cyclonamine depends on the selected form of the preparation:

1. 1 hard capsule of Cyclonamine 500 mg contains 500 mg of etamsylate. The other ingredients are stearic acid, titanium dioxide (E 171), erythrosine (E 127), quinoline yellow (E 104) and gelatin;
2. 1 tablet of Cyclonamine 250 mg contains 250 mg of etamsylate. The other ingredients are microcrystalline cellulose, colloidal anhydrous silica, potato starch, magnesium stearate, sodium carboxymethyl starch (type A) and sodium metabisulfite;
3. 1 ampoule (2 ml) of solution for injection Cyclonamine 250 mg / 2 ml contains 250 mg of ethamsylate. The other ingredients are sodium metabisulfite, sodium sulfite anhydrous and water for injections.

How does the circulatory system work? Check: The functions of the circulatory system,

Cyclonamine – indications for use

Cyclonamine has an anti-haemorrhagic effect. The properties of the drug and indications for its use, however, depend on the selected form of the preparation.

Cyclonamine in the form of hard capsules is used for:

1. the prevention and treatment of capillary bleeding (bleeding from small vessels), regardless of the cause and location of the bleeding;
2. the treatment of spotting and excessive or prolonged menstrual bleeding, whether related to or independent of the use of an IUD.

The drug Cyclonamine in the form of tablets is used for:

1. prevention and treatment of preoperative or postoperative capillary bleeding in all types of surgery with a field of good tissue perfusion (in otorhinolaryngology, gynecology, obstetrics, urology, dentistry, ophthalmology, plastic and reconstructive surgery);
2. prevention and treatment of capillary bleeding of various origins and locations (hematuria, bloody vomiting, blood in stools, epistaxis, bleeding gums);
3. the treatment of spotting and excessive menstrual bleeding caused by an intrauterine device.

What are menstrual disorders and how to deal with them? Read on: Menstrual disorders

Cyclonamine – contraindications

Cyclonamine, despite its effectiveness in stopping bleeding or haemorrhage, cannot be used by every patient struggling with this type of ailments.

Contraindications to the use of the drug Cyclonamine are:

1. allergy to etamsylate or any of the excipients of the drug;
2. acute porphyria – a condition characterized by disturbances in the synthesis of hemoglobin;
3. bronchial asthma – for injection solution;
4. deficiency of plasma coagulation factors;
5. cervical pathology, uterine fibroids.

What should you know about drug hypersensitivity? Check: Drugs are also allergenic

Cyclonamine – precautions

Before and during the use of Cyclonamine, follow the precautions, which are included in the package leaflet.

The precautions you should keep in mind depend on the form of the drug you are taking.

Cyclonamine hard capsules:

1. sampling for testing (e.g. blood samples) should be performed prior to the first dose of Cyclonamine in order to exclude any possible effects of the drug on the results of laboratory tests;
2. in case of treatment related to menstrual bleeding, the patient should be examined by a gynecologist before using Cyclonamine.

Cyclonamine in the form of tablets:

1. treatment should be discontinued in the event of fever;
2. if there is no improvement in treatment of excessive or prolonged menstrual bleeding, contact your doctor. 

Also note that:

1. the preparation in the form of tablets contains sodium metabisulfite, which may cause severe allergic reactions in particularly sensitive people;
2. the capsule formulation contains quinoline yellow (E104);
3. the drug should be stored in the original packaging in order to protect from moisture, at a temperature not higher than 25 degrees;
4. the drug should be kept out of the reach of children;
5. the medicine should not be used after the expiry date which is stated on the carton. The expiry date refers to the last day of that month;
6. this medicine should not be disposed of via wastewater or household waste. It’s best to ask your pharmacist how to dispose of medicines you no longer use.

What should you know about proper drug storage? Check: Medications that are stored wrongly are poisonous

Cyclonamine – dosage

Always use Cyclonamine exactly as described in the package leaflet or as directed by your doctor or pharmacist.

Cyclonamine hard capsules should be used according to the following recommendations:

1. treatment of internal diseases: 1 capsule 2-3 times a day (1000 – 1500 mg);
2. before surgery: 1 capsule (500 mg) an hour before surgery;
3. after surgery: 1 capsule (500 mg) every 4-6 hours as long as there is a risk of bleeding;
4. treatment of gynecological diseases: 1 capsule 3 times a day (1500 mg), treatment lasts 10 days, starts 5 days before the expected start of menstruation

The capsules should be taken orally with a meal and the dose washed down with water. The only exception is if the drug is taken before surgery, in which case the patient should be on an empty stomach. Cyclonamine at a dose of 500 mg should not be used in children and adolescents under 18 years of age.

In turn, the drug Cyclonamine in the form of tablets is used in accordance with the following instructions:

1. before surgery: 1 to 2 tablets (250 – 500 mg) one hour before surgery;
2. after surgery: 1 to 2 tablets (250 – 500 mg) every 4-6 hours as long as there is a risk of bleeding;
3. internal diseases: usually 2 tablets 2 to 3 times a day (1000-1500 mg);
4. gynecology, spotting and excessive menstrual bleeding: 2 tablets 3 times a day (1500 mg), treatment lasts 10 days, starts 5 days before the expected start of menstruation,

Cyclonamine tablets are taken orally while eating and washed down with a small amount of water. The exception is the use of the drug before surgery, when you should take the tablets on an empty stomach. For children and adolescents up to 18 years of age, the recommended dose is half the adult dose.

If you take too much Cyclonamine, consult a doctor as soon as possible or go to the nearest medical facility.

How to take medication correctly? Check: How to take medications effectively?

Cyclonamine – side effects

The drug Cyclonamine, like any other drug, may cause side effects in patients. It is important to report any suspected adverse reactions after authorization of the medicinal product so that the benefit / risk balance of the medicinal product can be monitored.

The frequency classification of adverse body reactions (ADRs) is based on the following principles: very common (≥1 / 10), common (≥1 / 100 to <1/10), uncommon (≥1 / 1 to <000/1), rare (≥ 100 / 1 to <10 / 000), very rare (<1 / 1), not known (cannot be estimated from the available data).

Due to the frequency of side effects, the following are indicated:

1. very common side effects of Cyclonamine use (may affect up to 1 in 10 people): headache, rash, abdominal pain, nausea, diarrhea, vomiting, abdominal discomfort, fatigue;
2. rare side effects of using Cyclonamine (may affect 1 to 10 in 10000 people): joint pain;
3. very rare side effects of using Cyclonamine (may affect up to 1 in 10000 people): fever, problems with blood clotting with blood clots in the vessels, severe reduction in the number of white blood cells, reduction in the number of platelets, allergic reaction

What causes an antibiotic rash? Read on: Antibiotic rash – is it an allergy symptom?

Cyclonamine and pregnancy and breastfeeding

The use of any medications or dietary supplements during pregnancy requires consultation with the attending physician. If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking Cyclonamine.

The preparation should not be used in pregnant women due to the lack of sufficient clinical data confirming the safety for the fetus and mother. The active substance in Cyclonamine, on the other hand, passes into breast milk, therefore its use in breast-feeding women is not recommended.

What is worth knowing about proper supplementation during pregnancy? Check: Conscious choices. Diet and supplementation in pregnancy

Cyclonamine — cena

The price of Cyclonamine may vary depending on the city in which the antibiotic is purchased or the pharmacy chosen by the patient. The price of the product also depends on the selected form of the drug and the number of tablets or capsules contained in the package:

1. 30 Cyclonamine tablets cost about PLN 25-30;
2. 60 Cyclonamine tablets cost about PLN 50;
3. 30 capsules of Cyclonamine cost about PLN 50-55;
4. 60 capsules of Cyclonamine cost about PLN 90-95.

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