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Ciclosporin is used to avoid transplant rejection after organ or bone marrow transplantation. This medicine helps the transplanted organ to take root. In addition, it is also used in the treatment of psoriasis, kidney disease, severe arthritis and atopic dermatitis. Cyclosporine is also effective in the treatment of inflammation – internal and external – such as itching or burning of the skin. Ciclosporin is also administered in cases of dry eyes, the so-called dry eye syndrome.
How to dose cyclosporine?
We take cyclosporine orally, the doctor decides how often. It is best to take it with a meal, but be careful not to drink grapefruit juice during this time. This juice increases the effect cyclosporins. It is usually given between 3 and 5 mg / kg body weight, 12 hours before organ transplant surgery. After surgery, it is used for about 2 weeks. When it comes to bone marrow transplant, it is given the day before surgery. Usually 3 to 5 mg / kg body weight. This dose of ciclosporin is also used two weeks after the bone marrow transplant. Follow the dose recommended by your doctor, as in excess ciclosporin may cause side effects.
Does cyclosporine have any side effects?
Unfortunately, cyclosporine is an organic compound that very often causes side effects in the body.
Belong to them:
- high level of fat in the blood
- body tremors
- headaches,
- high blood pressure,
- kidney problems.
Also:
- high levels of uric acid, potassium in the blood
- low levels of magnesium in the blood
- itching, stinging, numbness of the body.
Ciclosporin can also cause loss of appetite, nausea, vomiting, abdominal pain, liver disorders, muscle aches and general fatigue.
Like other immunosuppressants, cyclosporine increases the risk of developing lymphomas and other malignancies, especially skin cancers.
Ciclosporin may be allergic to it – inform your doctor about this. It reacts differently with other drugs, which also needs to be mentioned in medical consultations. Do not use the drug during pregnancy or breastfeeding.
What does the dose of the drug with cyclosporine contain?
Depending on the type of drug with cyclosporine, tablets are available in the following weight values: 25 mg, 50 mg or 100 mg – most often packed in 50 pieces. Names describing medicinal preparations containing cyclosporine are: Cyclaid, Equoral, Gengraf, Sandimmun Neoral.
Interactions of cyclosporine with other compounds and drugs
Ciclosporin is a substrate and an inhibitor of CYP3A4 and P-glycoprotein, and an inhibitor of organic anion transport proteins (OATP). When taking cyclosporin, blood levels should be monitored. In people with kidney problems, you should make sure that this does not cause any undesirable effects. It is not recommended to use cyclosporine with bosentan, St. John’s wort, tacrolimus.
1. Name of the drug / preparation: cyclosporine.
2. Introduction: I use cyclosporine to avoid transplant rejection after organ or bone marrow transplantation, as well as in other diseases.
3. Form, dose, packaging: Capsules. It is usually given between 3 and 5 mg / kg body weight 12 hours before organ transplant surgery. After surgery, it is used for about 2 weeks. When it comes to bone marrow transplantation, it is given the day before surgery. Usually 3 to 5 mg / kg body weight. This dose of ciclosporin is also used two weeks after the bone marrow transplant.
4. Availability category: After consulting a doctor, prescription.
5. Indication: Including transplantation, bone marrow transplant.
6. Contraindications to use: Do not use the drug during pregnancy or breastfeeding.
7. Warnings: We take cyclosporin orally, how often the doctor decides. It is best to take it with a meal, but be careful not to drink grapefruit juice during this time. This juice enhances the effect of cyclosporine.
8. Interactions: It is not recommended to use cyclosporine with bosentan, St. John’s wort, tacromilus.
9. Side effects:
These include: high blood fat levels, body tremors, headaches, high blood pressure, and kidney problems. In addition: high levels of uric acid, potassium in the blood, low levels of magnesium in the blood, itching, stinging, numbness of the body. Ciclosporin can also cause loss of appetite, nausea, vomiting, abdominal pain, liver disorders, muscle aches and general fatigue.
Ciclosporin may be allergic to it – inform your doctor about this. It reacts differently with other drugs, which also needs to be mentioned in medical consultations.