Comparison of drugs Dicloberl and Diclofenac

*Overview of the best according to the editors of Healthy Food Near Me. About selection criteria. This material is subjective, is not an advertisement and does not serve as a guide to the purchase. Before buying, you need to consult with a specialist.

Pain is a common companion of many diseases. It accompanies injuries and inflammatory processes, tumors, diseases of muscles, joints and ligaments. You can list for a long time, but the hero of our article will not be pain, but drugs that suppress it – non-steroidal anti-inflammatory drugs (NSAIDs). They relieve discomfort, inhibit the development and progression of the inflammatory process, alleviate the general condition, therefore they are used in the treatment of various diseases in both adults and children.

Our focus will be on two drugs based on the same active ingredient, diclofenac. This is one of the oldest and well-studied medicines from the NSAID group. One drug is called that – Diclofenac (in order not to get confused, the trade name is usually written with a capital letter), the other is Dicloberl. What is the difference between them and which tool is better, we will tell in the article.

How do drugs work?

Since the active substance of both drugs is the same, we will consider them together. The manufacturing technology of medicines may differ, however, according to international requirements, this should not affect the principle of operation of the active ingredient – diclofenac.

Diclofenac acts like all non-steroidal anti-inflammatory drugs – through the enzyme cyclooxygenase (COX). However, it must be borne in mind that there are two COXs in the human body, and each received its own unique number:

1. COX-1 is produced normally. It is necessary for the full functioning of internal organs.

2. COX-2 is synthesized only during inflammation – for example, against the background of arthritis or injury.

Presumably, there is also COX-3, but its role has not been fully studied and even its existence has not been proven.

When scientists developed NSAIDs in the middle of the last century, they assumed that such drugs would act on COX-2 and block inflammation. However, the COX-1 and COX-2 enzymes are very similar, and drugs often confuse them. NSAIDs of the old generation, such as diclofenac, are especially guilty of this. They are effective, proven, but not very “smart” – and when they enter the body, they block not only COX-2, but also COX-1. This explains the large number of adverse reactions that occur while taking diclofenac.

But back to the main action of NSAIDs – the blocking of COX-2. By acting on the enzyme, diclofenac disrupts the reaction cycle of the arachidonic cascade and prevents the formation of prostaglandin E2, thromboxane, prostacyclin and other components responsible for the development of the inflammatory reaction. There is no inflammation – there are no symptoms: pain, swelling, redness of tissues.

Important!

Diclofenac is a symptomatic remedy. It does not affect the cause and does not cure the disease, but only relieves the symptoms. Therefore, drugs based on diclofenac are not prescribed as the only medicines, but are used in combination with other methods of therapy.

Which drug is more effective

Diclofenac (as an active ingredient) is a long-known and well-studied remedy. In the PubMed medical knowledge base, he dedicated more than 13 thousand articles. You can trust this data – only reliable information about medicines is collected here.

Of greatest interest are the following studies:

1. In the review articlededicated to diclofenac, it is shown that the drug is not inferior in effectiveness to other non-steroidal anti-inflammatory drugs.

2. In 2008 year studied influence of local forms of diclofenac (in the form of gel and cream). Scientists have found that the drug is well distributed in tissues in sufficient concentration and provides the desired therapeutic effect. The authors also concluded that diclofenac was well tolerated and rarely caused adverse reactions.

3. In Cochrane review from 2016, an assessment was made of the effectiveness of diclofenac in musculoskeletal pain in adults. The authors studied only randomized, double-blind, placebo-controlled trials for moderate to severe pain and found that diclofenac effectively copes with its task.

4. В review from 2017 studied the effect of diclofenac and other NSAIDs in the treatment of acute and chronic pain in diseases of the musculoskeletal system. The authors found out that the drug relieves acute pain well, but its effectiveness is lower in chronic processes.

5. Medical Literature Review Shows: Diclofenac Is Good copes with pain in various pathological processes, including osteochondrosis, arthritis and arthrosis, etc.

6. There is proof of effectiveness of the drug in rheumatoid arthritis. Diclofenac relieves pain and inhibits the development of the inflammatory process, but does not directly affect the pathogenesis of the disease.

7. There are not many studies on specific drugs based on diclofenac. In Russian-language literature, one article according to Dicloberl. The study was conducted on the basis of the City Clinical Hospital in Semey. The authors studied the retard form of Dicloberl and concluded that capsules containing microgranules make it possible to prolong the action of the drug due to their gradual dissolution in the intestine and can stop pain and inflammation during the day. This form of release also reduces the risk of adverse reactions.

Comparative studies on the similarities and differences between Diclofenac and Dikorberl have not been conducted, so we cannot say which drug is more effective and safer. However, it is worth noting: both drugs are generics, and all the tests presented were carried out in relation to the original diclofenac produced by the Swiss company Ciba-Gaigi. By According to medical literature, generic drugs may not be as effective and more likely to cause unwanted side effects. This is due to the peculiarities of their production, the use of other technologies, auxiliary components, etc.

Показания

Diclofenac and Dicloberl are prescribed where pain and inflammation need to be relieved:

1. inflammatory diseases of the joints – for example, rheumatoid arthritis;

2. degenerative diseases of the joints – arthrosis of various origins;

3. diseases of periarticular tissues (tendons, ligaments, muscles, bags);

4. pathology of the spine;

5. condition after surgery or injury;

6. acute attack of gout;

7. primary algomenorrhea – painful menstruation not associated with a specific pathology of the pelvic organs;

8. inflammatory diseases of the pelvic organs – the uterus and appendages;

9. renal and hepatic colic;

10. migraine;

11. other conditions accompanied by pain syndrome.

12. NSAIDs are used orally or topically on the lesion.

Application Scheme

Diclofenac and Dicloberl are prescribed according to the general scheme:

1. Inside – in the form of tablets or capsules. The drug should be swallowed without chewing and washed down with water.

2. Parenterally – in the form of rectal suppositories or intramuscularly. Candles are prescribed in the presence of contraindications to oral forms (for example, diseases of the digestive tract). Intramuscular injections are recommended in the acute stage – they quickly relieve pain.

The exact dosage and duration of use is determined by the doctor after examining and examining the patient, taking into account his age, the nature and severity of the disease and the presence of concomitant conditions.

Adverse Reactions

Consider the side effects for the active substance diclofenac in both drugs:

1. Digestive tract: nausea, vomiting, abdominal pain, flatulence, diarrhea, constipation, drug erosion and gastric ulcer, bleeding, drug-induced hepatitis.

2. Urinary system: nephritis – kidney damage.

3. Nervous system: insomnia, irritability, fatigue.

4. Violation of the composition of the blood: a decrease in the level of erythrocytes, leukocytes and platelets. This can lead to the development of anemia, infectious diseases, bleeding.

5. Other symptoms: headache, swelling.

6. Allergic reactions.

The risk of developing adverse reactions increases with increasing dosage and duration of taking the drug.

Противопоказания

NSAIDs based on diclofenac are not used in such conditions:

1. Hypersensitivity to diclofenac and other NSAIDs – there may be a cross-allergic reaction.

2. Severe liver and kidney disease.

3. Hematopoietic disorders of unknown origin.

4. Peptic ulcer of the stomach and duodenum in the acute stage.

5. Pregnancy III trimester.

6. In the I and II trimesters of pregnancy, the drug is prescribed with caution and only if there is no other way out. According to the FDA category of action on the fetus – C up to 30 weeks and D after 30 weeks. This meansthat there is evidence of a negative effect of the drug on the fetus, identified in animal studies (category C) and in humans (category D).

With caution, the drug is prescribed during lactation and in childhood.

Conclusions

To sum up:

1. Diclofenac and Dicloberl are drugs from the NSAID group. They contain one active ingredient and are prescribed as a symptomatic remedy for pain and inflammation.

2. Diclofenac and Dicloberl have the same indications and contraindications.

Comparative studies on the difference between Diclofenac and Dicloberl have not been conducted. Both agents are generics. This must be taken into account, because all clinical trials were conducted in relation to the original Swiss-made diclofenac.

Attention! This material is subjective, is not an advertisement and does not serve as a guide to the purchase. Before buying, you need to consult with a specialist.